{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:59:23Z","timestamp":1793329163517,"version":"4.5.0"},"reference-count":128,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Increasing evidence indicates that acute kidney injury (AKI) occurs frequently in children and young adults and is associated with poor short-term and long-term outcomes. Guidance is required to focus efforts related to expansion of pediatric AKI knowledge.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To develop expert-driven pediatric specific recommendations on needed AKI research, education, practice, and advocacy.<\/jats:p>\n <\/jats:sec>\n \n Evidence Review<\/jats:title>\n At the 26th Acute Disease Quality Initiative meeting conducted in November 2021 by 47 multiprofessional international experts in general pediatrics, nephrology, and critical care, the panel focused on 6 areas: (1) epidemiology; (2) diagnostics; (3) fluid overload; (4) kidney support therapies; (5) biology, pharmacology, and nutrition; and (6) education and advocacy. An objective scientific review and distillation of literature through September 2021 was performed of (1) epidemiology, (2) risk assessment and diagnosis, (3) fluid assessment, (4) kidney support and extracorporeal therapies, (5) pathobiology, nutrition, and pharmacology, and (6) education and advocacy. Using an established modified Delphi process based on existing data, workgroups derived consensus statements with recommendations.<\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n The meeting developed 12 consensus statements and 29 research recommendations. Principal suggestions were to address gaps of knowledge by including data from varying socioeconomic groups, broadening definition of AKI phenotypes, adjudicating fluid balance by disease severity, integrating biopathology of child growth and development, and partnering with families and communities in AKI advocacy.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Existing evidence across observational study supports further efforts to increase knowledge related to AKI in childhood. Significant gaps of knowledge may be addressed by focused efforts.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2022.29442","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T11:34:17Z","timestamp":1664537657000},"page":"e2229442","source":"Crossref","is-referenced-by-count":159,"title":["Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children"],"prefix":"10.1001","volume":"5","author":[{"given":"Stuart L.","family":"Goldstein","sequence":"first","affiliation":[{"name":"Center for Acute Care Nephrology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Akcan-Arikan","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine and Nephrology, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashid","family":"Alobaidi","sequence":"additional","affiliation":[{"name":"Alberta Health Sciences University, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Askenazi","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Alabama, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Bagshaw","sequence":"additional","affiliation":[{"name":"Alberta Health Sciences University, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Barhight","sequence":"additional","affiliation":[{"name":"Ann & Robert Lurie Children\u2019s Hospital of Chicago, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Barreto","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benan","family":"Bayrakci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Medicine, Life Support Center, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orville N.R.","family":"Bignall","sequence":"additional","affiliation":[{"name":"Nationwide Children\u2019s Hospital, The Ohio State University, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Bjornstad","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Alabama, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"Brophy","sequence":"additional","affiliation":[{"name":"Golisano Children\u2019s Hospital, Rochester University Medical Center, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Chanchlani","sequence":"additional","affiliation":[{"name":"McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Charlton","sequence":"additional","affiliation":[{"name":"University of Virginia, Charlottesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Conroy","sequence":"additional","affiliation":[{"name":"Riley Children\u2019s Hospital, Indiana University, Bloomington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Deep","sequence":"additional","affiliation":[{"name":"King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Devarajan","sequence":"additional","affiliation":[{"name":"Center for Acute Care Nephrology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Dolan","sequence":"additional","affiliation":[{"name":"Mercy Children\u2019s Hospital Kansas City, Kansas City, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana Y.","family":"Fuhrman","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja M.","family":"Gist","sequence":"additional","affiliation":[{"name":"Center for Acute Care Nephrology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Gorga","sequence":"additional","affiliation":[{"name":"C.S. 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