{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:08:27Z","timestamp":1786975707537,"version":"build-2736575974"},"reference-count":50,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n \n Staphylococcus aureus<\/jats:italic>\n bacteremia is associated with a significant burden of mortality, morbidity, and health care costs. Infectious disease consultation may be associated with reduced mortality and bacteremia recurrence rates.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To evaluate the cost-effectiveness of infectious disease consultation for\n Staphylococcus aureus<\/jats:italic>\n bacteremia.\n <\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n \n In this economic evaluation, a decision-analytic model was constructed comparing infectious disease consult with no consult\n .<\/jats:italic>\n The population was adult hospital inpatients with\n Staphylococcus aureus<\/jats:italic>\n bacteremia diagnosed with at least 1 positive blood culture. Cost-effectiveness was calculated as deaths averted and incremental cost-effectiveness ratios. Uncertainty was addressed by plotting cost-effectiveness planes and acceptability curves for various willingness-to-pay thresholds. Costs and outcomes were calculated for a time horizon of 6 months. The analysis was performed from a societal perspective and included studies that had been published by January 2022.\n <\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n \n Patients received or did not receive formal bedside consultation after positive blood cultures for\n Staphylococcus aureus<\/jats:italic>\n bacteremia.\n <\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The main outcomes were incremental difference in effectiveness (survival probabilities), incremental difference in cost (US dollars) and incremental cost-effectiveness ratios (US dollars\/deaths averted).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n This model included 1708 patients who received consultation and 1273 patients who did not. In the base-case analysis, the cost associated with the infectious disease consult strategy was $54\u202f137.4 and the associated probability of survival was 0.77. For the no consult strategy, the cost was $57\u202f051.2, and the probability of survival was 0.72. The incremental difference in cost between strategies was $2913.8, and the incremental difference in effectiveness was 0.05. Overall, consultation was associated with estimated savings of $55\u202f613.4\/death averted (incremental cost-effectiveness ratio, \u2212$55613.4\/death averted). In the probabilistic analysis, at a willingness-to-pay threshold of $50\u202f000, infectious disease consult was cost-effective compared with no consult in 54% of 10\u202f000 simulations. In cost-effectiveness acceptability curves, the consult strategy was cost-effective in 58% to 73%) of simulations compared with no consult for a willingness-to-pay threshold ranging from $0 to $150\u202f000.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n \n These findings suggest that infectious disease consultation may be a cost-effective strategy for management of\n Staphylococcus aureus<\/jats:italic>\n bacteremia and that it is associated with health care cost-savings.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2022.34186","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T11:32:44Z","timestamp":1664451164000},"page":"e2234186","source":"Crossref","is-referenced-by-count":9,"title":["Economic Analysis of Infectious Disease Consultation for\n Staphylococcus aureus<\/i>\n Bacteremia Among Hospitalized Patients"],"prefix":"10.1001","volume":"5","author":[{"given":"Elina 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