{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:06:48Z","timestamp":1785928008791,"version":"3.56.0"},"reference-count":44,"publisher":"American Medical Association (AMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Interventions directly targeting social factors, such as education, may have the potential to greatly improve health.<\/jats:p><\/jats:sec>Objective<\/jats:title>To examine the association of attending a high-performing public charter high school with rates of substance use disorder and physical and mental health.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study used the random school admissions lottery system of high-performing public charter high schools in low-income neighborhoods of Los Angeles, California, to examine the health outcomes of students who applied to at least 1 of 5 of these high schools. Participants attended 147 different high schools and were randomly selected from those who won the admissions lottery (intervention group) and those who were placed on a waiting list (control group). Participants were surveyed at the end of grade 8 through transition into grade 9 and then from grade 10 through 3 years after high school completion (at age 21 years). Surveys were conducted from March 2013 through November 2021.<\/jats:p><\/jats:sec>Intervention<\/jats:title>Attendance at a high-performing public charter high school.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Self-reported alcohol use disorder and cannabis misuse, delinquent behaviors, physical and mental health, and body mass index.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 1270 participants at baseline (mean [SD] age, 14.2 [0.47] years; 668 female individuals [52.6%]). The control group included 576 individuals (45.4%), and 694 individuals (54.6%) were in the intervention group. Both groups were similar in almost all characteristics at baseline, and the median (IQR) follow-up was 6.4 (6.0-6.7) years. Participants attending a high-performing public charter high school had a 53.33% lower rate of hazardous or dependent alcohol use disorder compared with those in the control group (5.43% vs 11.64%; difference, \u22126.21% [95% CI, \u221211.87% to \u22120.55%]; P<\/jats:italic>\u2009=\u2009.03). Among male participants, the intervention group had a 42.05% lower rate of self-reported fair or poor physical health (13.33% vs 23.01%; difference, \u22129.67% [95% CI, \u221218.30% to \u22121.05%]; P<\/jats:italic>\u2009=\u2009.03) and a 32.94% lower rate of obesity or overweight (29.28% vs 43.67%; difference, \u221214.38% [95% CI, \u221225.74% to \u22123.02%]; P<\/jats:italic> = .02) compared with the control group. Among female participants, attending a high-performing public charter high school was associated with worse physical health outcomes (30.29% vs 13.47% reporting fair or poor health; difference, 16.82% [95% CI, 0.36% to 33.28%]; P<\/jats:italic> = .045) and higher rates of overweight or obesity (52.20% vs 32.91%; difference, 19.30% [95% CI, 3.37% to 35.22%]; P<\/jats:italic> = .02) at age 21 years. Few differences in mental health outcomes were observed. Adjusting for educational outcomes did not significantly change these findings.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>Results of this study suggest that attending a high-performing public charter high school was associated with lower rates of substance use disorder independent of academic achievement. Physical health and obesity outcomes were also better but only for young men; the intervention group had worse physical health outcomes among young women for unclear reasons. 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