{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:23:00Z","timestamp":1786188180446,"version":"build-2736575974"},"reference-count":41,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Evolving tobacco use patterns, including increasing electronic nicotine delivery systems (ENDS) use, warrant re-examination of the associations between tobacco use and oral health.<\/jats:p><\/jats:sec>Objective<\/jats:title>To examine associations between tobacco product use and incidence of adverse oral health outcomes.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study used nationally representative data from wave (W) 1 to W5 (2013-2019) of the Population Assessment of Tobacco and Health Study. Recruitment used a stratified address-based, area-probability household sample of the noninstitutionalized US civilian population. The W1 cohort included respondents aged 18 years and older without lifetime history of oral health outcomes at W1 or W3, depending on when the outcome was first assessed. Data analysis was performed from October 2021 to September 2022.<\/jats:p><\/jats:sec>Exposures<\/jats:title>Current (every day or someday use) established (lifetime use of at least 100 cigarettes or \u201cfairly regular\u201d use of other products) use of cigarettes, ENDS, cigars, pipes, hookah, snus, and smokeless tobacco, excluding snus at W1 to W4.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcomes were past 12-month self-reported diagnosis of gum disease and precancerous oral lesions (W2-W5) and bone loss around teeth, bleeding after brushing or flossing, loose teeth, and 1 or more teeth removed (W4-W5).<\/jats:p><\/jats:sec>Results<\/jats:title>Sample sizes varied across the 6 oral health outcomes (13\u202f149 respondents for the gum disease sample, 14\u202f993 respondents for the precancerous oral lesions sample, 16\u202f312 respondents for the bone loss around teeth sample, 10\u202f286 respondents for the bleeding after brushing or flossing sample, 15\u202f686 respondents for the loose teeth sample, and 12\u202f061 respondents for the 1 or more teeth removed sample). Slightly more than half of adults (52%-54% across the 6 samples) were women, and the majority were of non-Hispanic White race and ethnicity. Cox proportional hazards models were developed with covariates that included time-dependent tobacco use variables mutually adjusted for each other. Cigarette smoking was positively associated with incidence of gum disease diagnosis (adjusted hazard ratio [AHR], 1.33; 95% CI, 1.11-1.60), loose teeth (AHR, 1.35; 95% CI, 1.05-1.75), and 1 or more teeth removed (AHR, 1.43; 95% CI, 1.18-1.74). Cigar smoking was positively associated with incidence of precancerous oral lesions (AHR, 2.18; 95% CI, 1.38-3.43). In addition, hookah smoking was positively associated with incidence of gum disease diagnosis (AHR, 1.78; 95% CI, 1.20-2.63), and ENDS use was positively associated with incidence of bleeding after brushing or flossing (AHR, 1.27; 95% CI, 1.04-1.54). No associations were observed between snus and smokeless tobacco excluding snus and incidence of oral health outcomes.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>The observed associations of combustible tobacco use with incidence of several adverse oral health outcomes and ENDS use with incidence of bleeding after brushing or flossing highlight the importance of longitudinal studies and emphasize the continued importance of tobacco cessation counseling and resources in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2022.45909","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T16:31:00Z","timestamp":1670603460000},"page":"e2245909","source":"Crossref","is-referenced-by-count":27,"title":["Tobacco Use and Incidence of Adverse Oral Health Outcomes Among US Adults in the Population Assessment of Tobacco and Health Study"],"prefix":"10.1001","volume":"5","author":[{"given":"Marushka 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