{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:16:55Z","timestamp":1792001815224,"version":"4.4.0"},"reference-count":35,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi221302-4\"><jats:title>Importance<\/jats:title><jats:p>Measuring vaccination coverage rates and equity is crucial for informing immunization policies in China.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi221302-5\"><jats:title>Objectives<\/jats:title><jats:p>To estimate coverage rates and multidimensional equity for childhood vaccination in China.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi221302-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This cross-sectional study was conducted via a survey in 10 Chinese provinces between August 5 and October 16, 2019, among children ages 6 months to 5 years and their primary caregivers. Children\u2019s vaccination records and their primary caregivers\u2019 demographics and socioeconomic status were collected. Data were analyzed from November 2019 to March 2022.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi221302-7\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Vaccine coverage rates were measured as a percentage of National Immunization Program (NIP) and non-NIP vaccines administered before the day on which the child was surveyed. A multidimensional equity model applied a standardized approach to ranking individuals from least to most unfairly disadvantaged by estimating differences between observed vaccination status and estimated vaccination status as function of fair and unfair variation. Fair sources of variation in coverage included whether the child was of age to receive the vaccine, and unfair sources of variation included sex of the child and sociodemographic characteristics of caregivers. Absolute equity gaps (AEGs), concentration index values, and decompositions of factors associated with vaccine equity were estimated in the model.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi221302-8\"><jats:title>Results<\/jats:title><jats:p>Vaccine records and sociodemographic information of 5294 children (2976 [52.8%] boys and 2498 [47.2%] girls; age range, 6-59 months; 1547 children aged 12-23 months) and their primary caregivers were collected from 10 provinces. Fully immunized coverage under the NIP was 83.1% (95% CI, 82.0%-84.1%) at the national level and more than 80% in 7 provinces (province coverage ranged from 77.8% [95% CI, 74.3% to 81.3%] in Jiangxi to 88.4% [95% CI, 85.7%-91.1%] in Beijing). For most non-NIP vaccines, however, coverage rates were less than 50%, ranging from 1.8% (95% CI, 1.3%-2.2%) for the third dose of rotavirus vaccine to 67.1% (65.4% to 68.8%) for the first dose of the varicella vaccine. The first dose of <jats:italic>Haemophilus influenzae<\/jats:italic> type b vaccine had the largest AEG, at 0.603 (95% CI, 0.570-0.636), and rotavirus vaccine dose 3 had the largest concentration index value, at 0.769 (95% CI, 0.709-0.829). The largest share of non-NIP vaccine inequity was contributed by monthly family income per capita, followed by education level, place of residence, and province for caregivers. For example, the proportion of explained inequity for pneumococcal conjugate vaccine dose 3 was 40.94% (95% CI, 39.49%-42.39%), 22.67% (95% CI, 21.43%-23.9%), 27.15% (95% CI, 25.84%-28.46%), and 0.68% (95% CI, 0.44%-0.92%) for these factors, respectively.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi221302-9\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>This cross-sectional study found that NIP vaccination coverage in China was high but there was inequity for non-NIP vaccines. These findings suggest that improvements in equitable coverage of non-NIP vaccination may be urgently needed to meet national immunization goals.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2022.46005","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T16:31:02Z","timestamp":1670603462000},"page":"e2246005","source":"Crossref","is-referenced-by-count":64,"title":["Coverage and Equity of Childhood Vaccines in China"],"prefix":"10.1001","volume":"5","author":[{"given":"Haijun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Health Policy and Management, School of Public Health, Peking University, Beijing, China"},{"name":"China Center for Health Development Studies, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhen","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, School of Public Health, Peking University, Beijing, China"},{"name":"China Center for Health Development Studies, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Mak","sequence":"additional","affiliation":[{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salin","family":"Sriudomporn","sequence":"additional","affiliation":[{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, School of Public Health, Peking University, Beijing, China"},{"name":"China Center for Health Development Studies, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Fang","sequence":"additional","affiliation":[{"name":"China Center for Health Development Studies, Peking University, Beijing, China"},{"name":"Peking University Health Science Center, Chinese Center for Disease Control and Prevention Joint Research Center for Vaccine Economics, Beijing, China"},{"name":"Institute for Global Health and Development, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Patenaude","sequence":"additional","affiliation":[{"name":"International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"issue":"7-8","key":"zoi221302r1","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/S0264-410X(02)00623-0","article-title":"The global value of vaccination.","volume":"21","author":"Ehreth","year":"2003","journal-title":"Vaccine"},{"issue":"1579","key":"zoi221302r2","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1098\/rstb.2011.0076","article-title":"Vaccines and global health.","volume":"366","author":"Greenwood","year":"2011","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"7781","key":"zoi221302r3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41586-019-1656-7","article-title":"Immunization: vital progress, unfinished agenda.","volume":"575","author":"Piot","year":"2019","journal-title":"Nature"},{"issue":"1","key":"zoi221302r4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1186\/s12916-020-01699-3","article-title":"The burden of laboratory-confirmed pertussis in low- and middle-income countries since the inception of the Expanded Programme on Immunisation (EPI) in 1974: a systematic review and meta-analysis.","volume":"18","author":"Muloiwa","year":"2020","journal-title":"BMC Med"},{"issue":"12 Suppl 2","key":"zoi221302r5","doi-asserted-by":"publisher","first-page":"S452","DOI":"10.1093\/infdis\/jiab284","article-title":"The world of immunization: achievements, challenges, and strategic vision for the next decade.","volume":"224","author":"Lindstrand","year":"2021","journal-title":"J Infect Dis"},{"issue":"2","key":"zoi221302r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100113","article-title":"Impact of immunization programs on 11 childhood vaccine-preventable diseases in China: 1950-2018.","volume":"2","author":"Pan","year":"2021","journal-title":"Innovation (Camb)"},{"issue":"35","key":"zoi221302r12","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1016\/j.vaccine.2016.06.053","article-title":"Monitoring vaccination coverage: defining the role of surveys.","volume":"34","author":"Cutts","year":"2016","journal-title":"Vaccine"},{"issue":"7","key":"zoi221302r13","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14070758","article-title":"Evaluating childhood vaccination coverage of NIP vaccines: coverage survey versus Zhejiang provincial immunization information system.","volume":"14","author":"Hu","year":"2017","journal-title":"Int J Environ Res Public Health"},{"issue":"10299","key":"zoi221302r16","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S0140-6736(21)00984-3","article-title":"Measuring routine childhood vaccination coverage in 204 countries and territories, 1980-2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1.","volume":"398","author":"GBD 2020, Release 1, Vaccine Coverage Collaborators","year":"2021","journal-title":"Lancet"},{"key":"zoi221302r18","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2022.114979","article-title":"A standardized approach for measuring multivariate equity in vaccination coverage, cost-of-illness, and health outcomes: evidence from the Vaccine Economics Research for Sustainability & Equity (VERSE) project.","volume":"302","author":"Patenaude","year":"2022","journal-title":"Soc Sci Med"},{"key":"zoi221302r19","doi-asserted-by":"publisher","first-page":"27591","DOI":"10.3402\/gha.v8.27591","article-title":"Utility and limitations of measures of health inequities: a theoretical perspective.","volume":"8","author":"Alonge","year":"2015","journal-title":"Glob Health Action"},{"key":"zoi221302r20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.socscimed.2019.02.034","article-title":"Multiple inequity in health care: an example from Brazil.","volume":"228","author":"Barbosa","year":"2019","journal-title":"Soc Sci Med"},{"issue":"1","key":"zoi221302r21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S026646230605077X","article-title":"Equity-efficiency trade-offs in health technology assessment.","volume":"22","author":"Williams","year":"2006","journal-title":"Int J Technol Assess Health Care"},{"issue":"1","key":"zoi221302r23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jhealeco.2008.07.016","article-title":"Unfair inequalities in health and health care.","volume":"28","author":"Fleurbaey","year":"2009","journal-title":"J Health Econ"},{"issue":"10","key":"zoi221302r24","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1002\/hec.v20.10","article-title":"The concentration index of a binary outcome revisited.","volume":"20","author":"Wagstaff","year":"2011","journal-title":"Health Econ"},{"issue":"4","key":"zoi221302r25","doi-asserted-by":"publisher","first-page":"436","DOI":"10.2307\/144855","article-title":"Wage discrimination: reduced form and structural estimates.","volume":"8","author":"Blinder","year":"1973","journal-title":"J Hum Resour"},{"issue":"3","key":"zoi221302r26","doi-asserted-by":"publisher","first-page":"693","DOI":"10.2307\/2525981","article-title":"Male-female wage differentials in urban labor markets.","volume":"14","author":"Oaxaca","year":"1973","journal-title":"Int Econ Rev (Philadelphia)"},{"issue":"9389","key":"zoi221302r28","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/S0140-6736(03)14411-X","article-title":"Validity of reported vaccination coverage in 45 countries.","volume":"362","author":"Murray","year":"2003","journal-title":"Lancet"},{"issue":"8","key":"zoi221302r29","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1080\/21645515.2017.1327108","article-title":"Determinants of inequality in the up-to-date fully immunization coverage among children aged 24-35 months: evidence from Zhejiang province, East China.","volume":"13","author":"Hu","year":"2017","journal-title":"Hum Vaccin Immunother"},{"issue":"8","key":"zoi221302r31","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1016\/j.socscimed.2007.06.004","article-title":"Maternal education, child immunizations, and public policy: evidence from the US National Immunization Survey.","volume":"65","author":"Racine","year":"2007","journal-title":"Soc Sci Med"},{"issue":"10300","key":"zoi221302r32","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/S0140-6736(21)00534-1","article-title":"Parental education and inequalities in child mortality: a global systematic review and meta-analysis.","volume":"398","author":"Balaj","year":"2021","journal-title":"Lancet"},{"issue":"8","key":"zoi221302r33","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1002\/hec.v27.8","article-title":"Maternal education and childhood immunization in Turkey.","volume":"27","author":"\u00d6zer","year":"2018","journal-title":"Health Econ"},{"issue":"2","key":"zoi221302r34","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.socscimed.2012.02.043","article-title":"Linkages between maternal education and childhood immunization in India.","volume":"75","author":"Vikram","year":"2012","journal-title":"Soc Sci Med"},{"issue":"9","key":"zoi221302r35","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15092000","article-title":"Inequities in childhood vaccination coverage in Zhejiang, province: evidence from a decomposition analysis on two-round surveys.","volume":"15","author":"Hu","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"zoi221302r22","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/B978-0-444-53592-4.00016-5","volume-title":"Handbook of Health Economics, Vol 2","author":"Fleurbaey","year":"2011"},{"key":"zoi221302r27","volume-title":"China Population and Employment Statistics Yearbook 2020","author":"Department of Population and Employment Statistics, National Bureau of Statistics of China","year":"2020"},{"key":"zoi221302r6","unstructured":"World Health Organization. The Expanded Programme on Immunization. Accessed February 12, 2022. https:\/\/www.who.int\/teams\/immunization-vaccines-and-biologicals\/essential-programme-on-immunization"},{"key":"zoi221302r7","unstructured":"World Health Organization. Global vaccine action plan. Accessed February 12, 2022. https:\/\/www.who.int\/teams\/immunization-vaccines-and-biologicals\/strategies\/global-vaccine-action-plan"},{"key":"zoi221302r9","unstructured":"The National People\u2019s Congress of the People\u2019s Republic of China. Vaccine administration law of the People\u2019s Republic of China. Accessed February 12, 2022. http:\/\/www.npc.gov.cn\/npc\/c30834\/201907\/11447c85e05840b9b12c62b5b645fe9d.shtml"},{"key":"zoi221302r10","unstructured":"National Health Commission of the People\u2019s Republic of China. Healthy children action enhancement program 2021-2025. Accessed February 11, 2022. http:\/\/www.gov.cn\/zhengce\/zhengceku\/2021-11\/05\/content_5649019.htm"},{"key":"zoi221302r11","unstructured":"World Health Organization. Immunization dashboard: China. Accessed February 12, 2022. https:\/\/immunizationdata.who.int\/pages\/profiles\/chn.html"},{"key":"zoi221302r14","unstructured":"The Demographic and Health Surveys Program. The demographic and health surveys (DHS) program. Accessed February 12, 2022. https:\/\/dhsprogram.com\/"},{"key":"zoi221302r15","unstructured":"UNICEF. MICS. Accessed February 10, 2022. https:\/\/mics.unicef.org\/"},{"key":"zoi221302r17","unstructured":"The General Office of the State Council. Notice on the reform plan for the division of central and local financial governance and expenditure responsibilities in the healthcare sector. Accessed February 12, 2022. http:\/\/www.gov.cn\/zhengce\/content\/2018-08\/13\/content_5313489.htm"},{"key":"zoi221302r30","unstructured":"The World Bank. GDP per capita (current US$)\u2014China. Accessed February 12, 2022. https:\/\/data.worldbank.org\/indicator\/NY.GDP.PCAP.CD?locations=CN"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2799346\/zhang_2022_oi_221302_1669995561.08686.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T16:31:08Z","timestamp":1670603468000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2799346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,9]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.46005","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,9]]}}}