{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:08:35Z","timestamp":1791644915889,"version":"4.3.4"},"reference-count":32,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Severe obesity is a major health concern. However, a few patients remain resistant to bariatric surgery and other treatments. Animal studies suggest that weight may be altered by fecal microbiota transplantation (FMT) from a lean donor.<\/jats:p><\/jats:sec>Objective<\/jats:title>To determine whether FMT from a lean donor reduces body weight and further improves the results of bariatric surgery.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This double-blinded, placebo-controlled, multicenter, randomized clinical trial was conducted in 2018 to 2021 among adult individuals with severe obesity treated at 2 bariatric surgery centers in Finland and included 18 months of follow-up. Patients eligible for bariatric surgery were recruited for the study. Data were analyzed from March 2021 to May 2022.<\/jats:p><\/jats:sec>Interventions<\/jats:title>FMT from a lean donor or from the patient (autologous placebo) was administered by gastroscopy into the duodenum. Bariatric surgery was performed 6 months after the baseline intervention using laparoscopic Roux-en-Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG)<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The main outcome was weight reduction measured as the percentage of total weight loss (TWL).<\/jats:p><\/jats:sec>Results<\/jats:title>Forty-one patients were recruited to participate in the study and were included in the final analysis (29 women [71.1%]; mean [SD] age, 48.7 [8.7] years; mean [SD] body mass index, 42.5 [6.0]). A total of 21 patients received FMT from a lean donor, and 20 received an autologous placebo. Six months after FMT, 34 patients underwent LRYGB and 4 underwent LSG. Thirty-four patients (82.9%) attended the last visit 18 months after the baseline visit. The percentage of TWL at 6 months was 4.8% (95% CI, 2.7% to 7.0%; P<\/jats:italic>\u2009&amp;lt;\u2009.001) in the FMT group and 4.6% (95% CI, 1.5% to 7.6%; P<\/jats:italic>\u2009=\u2009.006) in the placebo group, but no difference was observed between the groups. At 18 months from the baseline (ie, 12 months after surgery), the percentage of TWL was 25.3% (95% CI, 19.5 to 31.1; P<\/jats:italic>\u2009&amp;lt;\u2009.001) in the FMT group and 25.2% (95% CI, 20.2 to 30.3; P<\/jats:italic>\u2009&amp;lt;\u2009.001) in the placebo group; however, no difference was observed between the groups.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>FMT did not affect presurgical and postsurgical weight loss. Further studies are needed to elucidate the possible role of FMT in obesity.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>ClinicalTrials.gov Identifier: NCT03391817<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2022.47226","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T16:31:57Z","timestamp":1671208317000},"page":"e2247226","source":"Crossref","is-referenced-by-count":65,"title":["Effectiveness of Fecal Microbiota Transplantation for Weight Loss in Patients With Obesity Undergoing Bariatric Surgery"],"prefix":"10.1001","volume":"5","author":[{"given":"Perttu","family":"Lahtinen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, P\u00e4ij\u00e4t-H\u00e4me Central Hospital, Lahti, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Juuti","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Luostarinen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, P\u00e4ij\u00e4t-H\u00e4me Central Hospital, Lahti, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Niskanen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, P\u00e4ij\u00e4t-H\u00e4me Central Hospital, Lahti, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Liukkonen","sequence":"additional","affiliation":[{"name":"Department of Nutrition, P\u00e4ij\u00e4t-H\u00e4me Central Hospital, Lahti, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyrki","family":"Tillonen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, P\u00e4ij\u00e4t-H\u00e4me Central Hospital, Lahti, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyrki","family":"K\u00f6ssi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, P\u00e4ij\u00e4t-H\u00e4me Central Hospital, Lahti, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesa","family":"Ilvesm\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, P\u00e4ij\u00e4t-H\u00e4me Central Hospital, Lahti, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Viljakka","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, P\u00e4ij\u00e4t-H\u00e4me Central Hospital, Lahti, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reetta","family":"Satokari","sequence":"additional","affiliation":[{"name":"Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perttu","family":"Arkkila","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"issue":"1","key":"zoi221335r1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years.","volume":"377","author":"Afshin","year":"2017","journal-title":"N Engl J Med"},{"key":"zoi221335r2","first-page":"1","article-title":"Obesity: preventing and managing the global epidemic. 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