{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:47:58Z","timestamp":1778219278695,"version":"3.51.4"},"reference-count":16,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi221387-4\"><jats:title>Importance<\/jats:title><jats:p>Data are limited regarding adverse reactions after COVID-19 vaccination in patients with a history of multisystem inflammatory syndrome in children (MIS-C). The lack of vaccine safety data in this unique population may cause hesitancy and concern for many families and health care professionals.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi221387-5\"><jats:title>Objective<\/jats:title><jats:p>To describe adverse reactions following COVID-19 vaccination in patients with a history of MIS-C.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi221387-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>In this multicenter cross-sectional study including 22 North American centers participating in a National Heart, Lung, and Blood Institute, National Institutes of Health\u2013sponsored study, Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children (MUSIC), patients with a prior diagnosis of MIS-C who were eligible for COVID-19 vaccination (age \u22655 years; \u226590 days after MIS-C diagnosis) were surveyed between December 13, 2021, and February 18, 2022, regarding COVID-19 vaccination status and adverse reactions.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi221387-7\"><jats:title>Exposures<\/jats:title><jats:p>COVID-19 vaccination after MIS-C diagnosis.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi221387-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>The main outcome was adverse reactions following COVID-19 vaccination. Comparisons were made using the Wilcoxon rank sum test for continuous variables and the \u03c7<jats:sup>2<\/jats:sup> or Fisher exact test for categorical variables.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi221387-9\"><jats:title>Results<\/jats:title><jats:p>Of 385 vaccine-eligible patients who were surveyed, 185 (48.1%) received at least 1 vaccine dose; 136 of the vaccinated patients (73.5%) were male, and the median age was 12.2 years (IQR, 9.5-14.7 years). Among vaccinated patients, 1 (0.5%) identified as American Indian\/Alaska Native, non-Hispanic; 9 (4.9%) as Asian, non-Hispanic; 45 (24.3%) as Black, non-Hispanic; 59 (31.9%) as Hispanic or Latino; 53 (28.6%) as White, non-Hispanic; 2 (1.1%) as multiracial, non-Hispanic; and 2 (1.1%) as other, non-Hispanic; 14 (7.6%) had unknown or undeclared race and ethnicity. The median time from MIS-C diagnosis to first vaccine dose was 9.0 months (IQR, 5.1-11.9 months); 31 patients (16.8%) received 1 dose, 142 (76.8%) received 2 doses, and 12 (6.5%) received 3 doses. Almost all patients received the BNT162b2 vaccine (347 of 351 vaccine doses [98.9%]). Minor adverse reactions were observed in 90 patients (48.6%) and were most often arm soreness (62 patients [33.5%]) and\/or fatigue (32 [17.3%]). In 32 patients (17.3%), adverse reactions were treated with medications, most commonly acetaminophen (21 patients [11.4%]) or ibuprofen (11 [5.9%]). Four patients (2.2%) sought medical evaluation, but none required testing or hospitalization. There were no patients with any serious adverse events, including myocarditis or recurrence of MIS-C.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi221387-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>In this cross-sectional study of patients with a history of MIS-C, no serious adverse events were reported after COVID-19 vaccination. These findings suggest that the safety profile of COVID-19 vaccination administered at least 90 days following MIS-C diagnosis appears to be similar to that in the general population.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2022.48987","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T16:06:14Z","timestamp":1672761974000},"page":"e2248987","source":"Crossref","is-referenced-by-count":15,"title":["Examination of Adverse Reactions After COVID-19 Vaccination Among Patients With a History of Multisystem Inflammatory Syndrome in Children"],"prefix":"10.1001","volume":"6","author":[{"given":"Matthew D.","family":"Elias","sequence":"first","affiliation":[{"name":"Division of Cardiology, The Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongngan T.","family":"Truong","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, University of Utah, Primary Children\u2019s Hospital, Salt Lake City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew E.","family":"Oster","sequence":"additional","affiliation":[{"name":"Children\u2019s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia L.","family":"Trachtenberg","sequence":"additional","affiliation":[{"name":"HealthCore Inc, Newton, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Mu","sequence":"additional","affiliation":[{"name":"HealthCore Inc, Newton, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Ni","family":"Jone","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Cardiology, Children\u2019s Hospital Colorado, University of Colorado, Anschutz Medical Campus, Aurora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth C.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Cohen Children\u2019s Medical Center, Northwell Health, New Hyde Park, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten B.","family":"Dummer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, University of California, San Diego, School of Medicine and Rady Children\u2019s Hospital, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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