{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:25:41Z","timestamp":1789701941877,"version":"4.0.1"},"reference-count":42,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Opioid-induced constipation (OIC) is prevalent among patients treated with opioids for cancer pain. Safe and effective therapies for OIC in patients with cancer remain an unmet need.<\/jats:p><\/jats:sec>Objective<\/jats:title>To determine the efficacy of electroacupuncture (EA) for OIC in patients with cancer.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This randomized clinical trial was conducted at 6 tertiary hospitals in China among 100 adult patients with cancer who were screened for OIC and enrolled between May 1, 2019, and December 11, 2021.<\/jats:p><\/jats:sec>Interventions<\/jats:title>Patients were randomized to receive 24 sessions of EA or sham electroacupuncture (SA) over 8 weeks and then were followed up for 8 weeks after treatment.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcome was the proportion of overall responders, defined as patients who had at least 3 spontaneous bowel movements (SBMs) per week and an increase of at least 1 SBM from baseline in the same week for at least 6 of the 8 weeks of the treatment period. All statistical analyses were based on the intention-to-treat principle.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 100 patients (mean [SD] age, 64.4 [10.5] years; 56 men [56.0%]) underwent randomization; 50 were randomly assigned to each group. Among them, 44 of 50 patients (88.0%) in the EA group and 42 of 50 patients (84.0%) in the SA group received at least 20 (\u226583.3%) sessions of treatment. The proportion of overall responders at week 8 was 40.1% (95% CI, 26.1%-54.1%) in the EA group and 9.0% (95% CI, 0.5%-17.4%) in the SA group (difference between groups, 31.1 percentage points [95% CI, 14.8-47.6 percentage points]; P<\/jats:italic>\u2009&amp;lt;\u2009.001). Compared with SA, EA provided greater relief for most OIC symptoms and improved quality of life among patients with OIC. Electroacupuncture had no effects on cancer pain and its opioid treatment dosage. Electroacupuncture-related adverse events were rare, and, if any, all were mild and transient.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>This randomized clinical trial found that 8-week EA treatment could increase weekly SBMs with a good safety profile and improve quality of life for the treatment of OIC. Electroacupuncture thus provided an alternative option for OIC in adult patients with cancer.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>ClinicalTrials.gov Identifier: NCT03797586<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.0310","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T16:01:26Z","timestamp":1677081686000},"page":"e230310","source":"Crossref","is-referenced-by-count":34,"title":["Effects of Electroacupuncture for Opioid-Induced Constipation in Patients With Cancer in China"],"prefix":"10.1001","volume":"6","author":[{"given":"Weiming","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Acumox and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Acupuncture Rehabilitation, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenghui","family":"Yue","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Tuina, Hunan University of Chinese Medicine, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianrong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Wang Jing Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine, ThedaCare Regional Medical Center\u2013Appleton, Appleton, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Oncology, Yantai Hospital of Traditional Chinese Medicine, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Yantai Hospital of Traditional Chinese Medicine, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Zhejiang Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Acumox and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Acupuncture Rehabilitation, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinna","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"issue":"5","key":"zoi230023r1","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/S1470-2045(09)70350-X","article-title":"Intravenous morphine for management of cancer pain.","volume":"11","author":"Mercadante","year":"2010","journal-title":"Lancet 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