{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:33:58Z","timestamp":1793205238754,"version":"4.5.0"},"reference-count":38,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Baseline findings from the China Dialysis Calcification Study (CDCS) revealed a high prevalence of vascular calcification (VC) among patients with end-stage kidney disease; however, data on VC progression were limited.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To understand the progression of VC at different anatomical sites, identify risk factors for VC progression, and assess the association of VC progression with the risk of cardiovascular events and death among patients receiving maintenance dialysis.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study was a 4-year follow-up assessment of participants in the CDCS, a nationwide multicenter prospective cohort study involving patients aged 18 to 74 years who were undergoing hemodialysis or peritoneal dialysis. Participants were recruited from 24 centers across China between May 1, 2014, and April 30, 2015, and followed up for 4 years. A total of 1489 patients receiving maintenance dialysis were included in the current analysis. Data were analyzed from September 1 to December 31, 2021.<\/jats:p><\/jats:sec>Exposures<\/jats:title>Patient demographic characteristics and medical history; high-sensitivity C-reactive protein laboratory values; serum calcium, phosphorus, and intact parathyroid hormone (iPTH) values; and previous or concomitant use of medications.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcome was progression of VC at 3 different anatomical sites (coronary artery, abdominal aorta, and cardiac valves) and identification of risk factors for VC progression. Participants received assessments of coronary artery calcification (CAC), abdominal aortic calcification (AAC), and cardiac valve calcification (CVC) at baseline, 24 months, 36 months, and 48 months. Secondary outcomes included (1) the association between VC progression and the risk of all-cause death, cardiovascular (CV)\u2013related death, and a composite of all-cause death and nonfatal CV events and (2) the association between achievement of serum calcium, phosphorus, and iPTH target levels and the risk of VC progression.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 1489 patients, the median (IQR) age was 51.0 (41.0-60.0) years; 59.5% of patients were male. By the end of 4-year follow-up, progression of total VC was observed in 86.5% of patients; 69.6% of patients had CAC progression, 72.4% had AAC progression, and 33.4% had CVC progression. Common risk factors for VC progression at the 3 different anatomical sites were older age and higher fibroblast growth factor 23 levels. Progression of CAC was associated with a higher risk of all-cause death (model 1 [adjusted for age, sex, and body mass index]: hazard ratio [HR], 1.97 [95% CI, 1.16-3.33]; model 2 [adjusted for all factors in model 1 plus smoking status, history of diabetes, and mean arterial pressure]: HR, 1.89 [95% CI, 1.11-3.21]; model 3 [adjusted for all factors in model 2 plus calcium, phosphorus, intact parathyroid hormone, and fibroblast growth factor 23 levels and calcium-based phosphate binder use]: HR, 1.92 [95% CI, 1.11-3.31]) and the composite of all-cause death and nonfatal CV events (model 1: HR, 1.98 [95% CI, 1.19-3.31]; model 2: HR, 1.91 [95% CI, 1.14-3.21]; model 3: HR, 1.95 [95% CI, 1.14-3.33]) after adjusting for all confounding factors except the presence of baseline calcification. Among the 3 targets of calcium, phosphorus, and iPTH, patients who achieved no target levels (model 1: odds ratio [OR], 4.75 [95% CI, 2.65-8.52]; model 2: OR, 4.81 [95% CI, 2.67-8.66]; model 3 [for this analysis, adjusted for all factors in model 2 plus fibroblast growth factor 23 level and calcium-based phosphate binder use]: OR, 2.76 [95% CI, 1.48-5.16]), 1 target level (model 1: OR, 3.71 [95% CI, 2.35-5.88]; model 2: OR, 3.62 [95% CI, 2.26-5.78]; model 3: OR, 2.19 [95% CI, 1.33-3.61]), or 2 target levels (model 1: OR, 2.73 [95% CI, 1.74-4.26]; model 2: OR, 2.69 [95% CI, 1.71-4.25]; model 3: OR, 1.72 [95% CI, 1.06-2.79]) had higher odds of CAC progression compared with patients who achieved all 3 target levels.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this study, VC progressed rapidly in patients undergoing dialysis, with different VC types associated with different rates of prevalence and progression. Consistent achievement of serum calcium, phosphorus, and iPTH target levels was associated with a lower risk of CAC progression. These results may be useful for increasing patient awareness and developing appropriate strategies to improve the management of chronic kidney disease\u2013mineral and bone disorder among patients undergoing dialysis.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.10909","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T11:01:39Z","timestamp":1682938899000},"page":"e2310909","source":"Crossref","is-referenced-by-count":114,"title":["Progression of Vascular Calcification and Clinical Outcomes in Patients Receiving Maintenance Dialysis"],"prefix":"10.1001","volume":"6","author":[{"given":"Haitao","family":"Zhang","sequence":"first","affiliation":[{"name":"National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sichuan Provincial People\u2019s Hospital, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Guangdong Provincial People\u2019s Hospital, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Center of Kidney Disease, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aili","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Kidney Diseases and Blood Purification, The Second Hospital of Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Nephrology Department, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhou","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Jinshazhou Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinling","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhuang","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Blood Purification Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Peking University People\u2019s Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changying","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Jiangsu Province Hospital, First Affiliated Hospital Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangcheng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sichuan Provincial People\u2019s Hospital, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Internal Medicine, Peking University First Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjun","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhongshan Hospital Xiamen University, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Peng","sequence":"additional","affiliation":[{"name":"Center for Nephrology and Metabolomics, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Institute of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanming","family":"Hao","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Huashan Hospital Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bicheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The 960th Hospital of the PLA, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Shen","sequence":"additional","affiliation":[{"name":"Sanofi, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Jia","sequence":"additional","affiliation":[{"name":"Sanofi, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"China Dialysis Calcification Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Zheng","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiling","family":"Chen","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunhuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Bian","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ye","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Jia","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Yu","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqin","family":"Wang","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Xu","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Xu","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilian","family":"Li","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Yuan","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangying","family":"Gan","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Zhao","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Ge","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Yang","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"He","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Sun","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongjing","family":"Yuan","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihong","family":"Yuan","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zou","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Cheng","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Gao","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxiang","family":"Song","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Shang","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyu","family":"Jia","sequence":"additional","affiliation":[{"name":"for the China Dialysis Calcification Study Group"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2023,5,1]]},"reference":[{"issue":"11","key":"zoi230345r1","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1161\/CIRCULATIONAHA.120.050686","article-title":"Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options.","volume":"143","author":"Jankowski","year":"2021","journal-title":"Circulation"},{"issue":"3","key":"zoi230345r2","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/hdi.2013.17.issue-3","article-title":"Evaluation of association between atherogenic index of plasma and intima-media thickness of the carotid artery for subclinic atherosclerosis in patients on maintenance hemodialysis.","volume":"17","author":"Yildiz","year":"2013","journal-title":"Hemodial Int"},{"issue":"3","key":"zoi230345r3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3390\/toxins12030181","article-title":"Cardiovascular calcification in chronic kidney disease\u2014therapeutic opportunities.","volume":"12","author":"Himmelsbach","year":"2020","journal-title":"Toxins (Basel)"},{"issue":"7","key":"zoi230345r4","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1093\/ndt\/gft368","article-title":"Vascular calcification in chronic kidney disease: are biomarkers useful for probing the pathobiology and the health risks of this process in the clinical scenario?","volume":"29","author":"Liabeuf","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"zoi230345r5","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1159\/000492953","article-title":"Prognostic cardiovascular markers in chronic kidney disease.","volume":"43","author":"Chen","year":"2018","journal-title":"Kidney Blood Press Res"},{"key":"zoi230345r6","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1111\/hdi.2013.17.issue-s1","article-title":"Vascular calcification in end-stage renal disease.","volume":"17","author":"Jablonski","year":"2013","journal-title":"Hemodial Int"},{"issue":"1","key":"zoi230345r7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.kisu.2017.04.001","article-title":"KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease\u2013mineral and bone disorder (CKD-MBD).","volume":"7","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group","year":"2017","journal-title":"Kidney Int Suppl (2011)"},{"issue":"4","key":"zoi230345r8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1159\/000500053","article-title":"Executive summary: clinical practice guideline of chronic kidney disease\u2013mineral and bone disorder (CKD-MBD) in China.","volume":"5","author":"Liu","year":"2019","journal-title":"Kidney Dis (Basel)"},{"issue":"8","key":"zoi230345r9","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1080\/03007995.2018.1467886","article-title":"Prevalence and risk factors for vascular calcification in Chinese patients receiving dialysis: baseline results from a prospective cohort study.","volume":"34","author":"Liu","year":"2018","journal-title":"Curr Med Res Opin"},{"key":"zoi230345r10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12882-015-0132-3","article-title":"Vascular calcification burden of Chinese patients with chronic kidney disease: methodology of a cohort study.","volume":"16","author":"Liu","year":"2015","journal-title":"BMC Nephrol"},{"key":"zoi230345r11","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-019-00500-x"},{"key":"zoi230345r12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"issue":"12","key":"zoi230345r13","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.jcmg.2010.08.018","article-title":"Progression of coronary artery calcium predicts all-cause mortality.","volume":"3","author":"Budoff","year":"2010","journal-title":"JACC Cardiovasc Imaging"},{"key":"zoi230345r14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.atherosclerosis.2016.08.004","article-title":"Predictors of abdominal aortic calcification progression in patients with chronic kidney disease without hemodialysis.","volume":"253","author":"Yamamoto","year":"2016","journal-title":"Atherosclerosis"},{"issue":"5","key":"zoi230345r15","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.2214\/ajr.182.5.1821327","article-title":"Evaluating changes in coronary artery calcium: an analytic method that accounts for interscan variability.","volume":"182","author":"Hokanson","year":"2004","journal-title":"AJR Am J Roentgenol"},{"issue":"7","key":"zoi230345r16","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1161\/CIRCULATIONAHA.116.027034","article-title":"Value of progression of coronary artery calcification for risk prediction of coronary and cardiovascular events: result of the HNR study (Heinz Nixdorf Recall).","volume":"137","author":"Lehmann","year":"2018","journal-title":"Circulation"},{"issue":"6719","key":"zoi230345r17","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1136\/bmj.300.6719.230","article-title":"Analysis of serial measurements in medical research.","volume":"300","author":"Matthews","year":"1990","journal-title":"BMJ"},{"issue":"12","key":"zoi230345r18","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/ki.2011.47","article-title":"Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease.","volume":"79","author":"Isakova","year":"2011","journal-title":"Kidney Int"},{"issue":"8","key":"zoi230345r19","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.1093\/ndt\/gfs259","article-title":"FGF-23: the rise of a novel cardiovascular risk marker in CKD.","volume":"27","author":"Heine","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"zoi230345r20","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/364890","article-title":"Clinical significance of FGF-23 in patients with CKD.","volume":"2011","author":"Russo","year":"2011","journal-title":"Int J Nephrol"},{"issue":"7","key":"zoi230345r21","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.2215\/CJN.08241109","article-title":"Fibroblast growth factor-23 in early chronic kidney disease: additional support in favor of a phosphate-centric paradigm for the pathogenesis of secondary hyperparathyroidism.","volume":"5","author":"Evenepoel","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"zoi230345r22","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1681\/ASN.2006080936","article-title":"Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) study.","volume":"18","author":"Fliser","year":"2007","journal-title":"J Am Soc Nephrol"},{"issue":"26","key":"zoi230345r23","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1056\/NEJMoa1205624","article-title":"Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis.","volume":"367","author":"Chertow","year":"2012","journal-title":"N Engl J Med"},{"issue":"10","key":"zoi230345r24","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1681\/ASN.2014070686","article-title":"High parathyroid hormone level and osteoporosis predict progression of coronary artery calcification in patients on dialysis.","volume":"26","author":"Malluche","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"zoi230345r25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.119.009495","article-title":"Association of body mass index with coronary artery calcium and subsequent cardiovascular mortality: the Coronary Artery Calcium Consortium.","volume":"13","author":"Jensen","year":"2020","journal-title":"Circ Cardiovasc Imaging"},{"issue":"4","key":"zoi230345r26","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1161\/HYPERTENSIONAHA.109.147520","article-title":"Blood pressure and vascular calcification.","volume":"55","author":"Jensky","year":"2010","journal-title":"Hypertension"},{"key":"zoi230345r27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12882-015-0103-8","article-title":"Hyperphosphatemia as an independent risk factor for coronary artery calcification progression in peritoneal dialysis patients.","volume":"16","author":"Shang","year":"2015","journal-title":"BMC Nephrol"},{"issue":"10","key":"zoi230345r28","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/j.amjcard.2017.02.021","article-title":"Relation of risk factors and abdominal aortic calcium to progression of coronary artery calcium (from the Framingham Heart Study).","volume":"119","author":"Onuma","year":"2017","journal-title":"Am J Cardiol"},{"issue":"7","key":"zoi230345r29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133938","article-title":"New conclusions regarding comparison of sevelamer and calcium-based phosphate binders in coronary-artery calcification for dialysis patients: a meta-analysis of randomized controlled trials.","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"issue":"9900","key":"zoi230345r30","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/S0140-6736(13)60897-1","article-title":"Effect of calcium-based versus non\u2013calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis.","volume":"382","author":"Jamal","year":"2013","journal-title":"Lancet"},{"issue":"3","key":"zoi230345r31","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1177\/2040622315578654","article-title":"The prevalence of vascular calcification in patients with end-stage renal disease on hemodialysis: a cross-sectional observational study.","volume":"6","author":"Kraus","year":"2015","journal-title":"Ther Adv Chronic Dis"},{"issue":"7","key":"zoi230345r32","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1093\/ndt\/gfm031","article-title":"Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis.","volume":"22","author":"Yamada","year":"2007","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"zoi230345r33","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1159\/000443620","article-title":"Risk factors for new-onset cardiac valve calcification in patients on maintenance peritoneal dialysis.","volume":"6","author":"Tian","year":"2016","journal-title":"Cardiorenal Med"},{"issue":"8","key":"zoi230345r34","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.arcmed.2013.10.015","article-title":"De novo development of heart valve calcification in incident peritoneal dialysis patients.","volume":"44","author":"Avila-D\u00edaz","year":"2013","journal-title":"Arch Med Res"},{"issue":"8","key":"zoi230345r35","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1681\/ASN.2022010080","article-title":"Coronary artery calcification score and the progression of chronic kidney disease.","volume":"33","author":"Yun","year":"2022","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"zoi230345r36","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1001\/jamacardio.2017.0363","article-title":"Coronary artery calcification and risk of cardiovascular disease and death among patients with chronic kidney disease.","volume":"2","author":"Chen","year":"2017","journal-title":"JAMA Cardiol"},{"issue":"1","key":"zoi230345r37","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1080\/0886022X.2019.1595646","article-title":"Prevalence of coronary artery calcification and its association with mortality, cardiovascular events in patients with chronic kidney disease: a systematic review and meta-analysis.","volume":"41","author":"Wang","year":"2019","journal-title":"Ren Fail"},{"issue":"5","key":"zoi230345r38","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.2215\/CJN.01060308","article-title":"Consistent control of mineral and bone disorder in incident hemodialysis patients.","volume":"3","author":"Danese","year":"2008","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2804372\/zhang_2023_oi_230345_1682086696.2537.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T11:01:42Z","timestamp":1682938902000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2804372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.10909","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,1]]}}}