{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:02:49Z","timestamp":1791932569137,"version":"4.3.4"},"reference-count":49,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Socioeconomic status affects pregnancy and neurodevelopment, but its association with hospital outcomes among premature infants is unknown. The Area Deprivation Index (ADI) is a validated measure of neighborhood disadvantage that uses US Census Bureau data on income, educational level, employment, and housing quality.<\/jats:p><\/jats:sec>Objective<\/jats:title>To determine whether ADI is associated with neonatal intensive care unit (NICU) mortality and morbidity in extremely premature infants.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This retrospective cohort study was performed at 4 level IV NICUs in the US Northeast, Mid-Atlantic, Midwest, and South regions. Non-Hispanic White and Black infants with gestational age of less than 29 weeks and born between January 1, 2012, and December 31, 2020, were included in the analysis. Addresses were converted to census blocks, identified by Federal Information Processing Series codes, to link residences to national ADI percentiles.<\/jats:p><\/jats:sec>Exposures<\/jats:title>ADI, race, birth weight, sex, and outborn status.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>In the primary outcome, the association between ADI and NICU mortality was analyzed using bayesian logistic regression adjusted for race, birth weight, outborn status, and sex. Risk factors were considered significant if the 95% credible intervals excluded zero. In the secondary outcome, the association between ADI and NICU morbidities, including late-onset sepsis, necrotizing enterocolitis (NEC), and severe intraventricular hemorrhage (IVH), were also analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 2765 infants with a mean (SD) gestational age of 25.6\u2009(1.7) weeks and mean (SD) birth weight of 805\u2009(241) g were included in the analysis. Of these, 1391 (50.3%) were boys, 1325 (47.9%) reported Black maternal race, 498 (18.0%) died before NICU discharge, 692 (25.0%) developed sepsis or NEC, and 353 (12.8%) had severe IVH. In univariate analysis, higher median ADI was found among Black compared with White infants (77 [IQR, 45-93] vs 57 [IQR, 32-77]; P<\/jats:italic> &amp;lt; .001), those who died before NICU discharge vs survived (71 [IQR, 45-89] vs 64 [IQR, 36-86]), those with late-onset sepsis or NEC vs those without (68 [IQR, 41-88] vs 64 [IQR, 35-86]), and those with severe IVH vs those without (69 [IQR, 44-90] vs 64 [IQR, 36-86]). In a multivariable bayesian logistic regression model, lower birth weight, higher ADI, and male sex were risk factors for mortality (95% credible intervals excluded zero), while Black race and outborn status were not. The ADI was also identified as a risk factor for sepsis or NEC and severe IVH.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>The findings of this cohort study of extremely preterm infants admitted to 4 NICUs in different US geographic regions suggest that ADI was a risk factor for mortality and morbidity after adjusting for multiple covariates.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.11761","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T15:02:28Z","timestamp":1683817348000},"page":"e2311761","source":"Crossref","is-referenced-by-count":51,"title":["Neighborhood Deprivation and Association With Neonatal Intensive Care Unit Mortality and Morbidity for Extremely Premature Infants"],"prefix":"10.1001","volume":"6","author":[{"given":"Brynne A.","family":"Sullivan","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayush","family":"Doshi","sequence":"additional","affiliation":[{"name":"currently a medical student at University of Virginia School of Medicine, Charlottesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Chernyavskiy","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameena","family":"Husain","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Washington University in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Binai","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Washington University in St Louis, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Sahni","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen D.","family":"Fairchild","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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