{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:07:15Z","timestamp":1786975635413,"version":"build-2736575974"},"reference-count":25,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi230410-4\">\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>The prevalence of urinary tract infection (UTI), bacteremia, and bacterial meningitis in febrile infants with SARS-CoV-2 is largely unknown. Knowledge of the prevalence of these bacterial infections among febrile infants with SARS-CoV-2 can inform clinical decision-making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi230410-5\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the prevalence of UTI, bacteremia, and bacterial meningitis among febrile infants aged 8 to 60 days with SARS-CoV-2 vs without SARS-CoV-2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi230410-6\">\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>This multicenter cross-sectional study was conducted as part of a quality improvement initiative at 106 hospitals in the US and Canada. Participants included full-term, previously healthy, well-appearing infants aged 8 to 60 days without bronchiolitis and with a temperature of at least 38 \u00b0C who underwent SARS-CoV-2 testing in the emergency department or hospital between November 1, 2020, and October 31, 2022. Statistical analysis was performed from September 2022 to March 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi230410-7\">\n                    <jats:title>Exposures<\/jats:title>\n                    <jats:p>SARS-CoV-2 positivity and, for SARS-CoV-2\u2013positive infants, the presence of normal vs abnormal inflammatory marker (IM) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi230410-8\">\n                    <jats:title>Main Outcomes and Measures<\/jats:title>\n                    <jats:p>Outcomes were ascertained by medical record review and included the prevalence of UTI, bacteremia without meningitis, and bacterial meningitis. The proportion of infants who were SARS-CoV-2 positive vs negative was calculated for each infection type, and stratified by age group and normal vs abnormal IMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi230410-9\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 14\u202f402 febrile infants with SARS-CoV-2 testing, 9841 (68.3%) were aged 29 to 60 days; 8143 (56.5%) were male; and 3753 (26.1%) tested positive. Compared with infants who tested negative, a lower proportion of infants who tested positive for SARS-CoV-2 had UTI (0.8% [95% CI, 0.5%-1.1%]) vs 7.6% [95% CI, 7.1%-8.1%]), bacteremia without meningitis (0.2% [95% CI, 0.1%-0.3%] vs 2.1% [95% CI, 1.8%-2.4%]), and bacterial meningitis (&amp;amp;lt;0.1% [95% CI, 0%-0.2%] vs 0.5% [95% CI, 0.4%-0.6%]). Among infants aged 29 to 60 days who tested positive for SARS-CoV-2, 0.4% (95% CI, 0.2%-0.7%) had UTI, less than 0.1% (95% CI, 0%-0.2%) had bacteremia, and less than 0.1% (95% CI, 0%-0.1%) had meningitis. Among SARS-CoV-2\u2013positive infants, a lower proportion of those with normal IMs had bacteremia and\/or bacterial meningitis compared with those with abnormal IMs (&amp;amp;lt;0.1% [0%-0.2%] vs 1.8% [0.6%-3.1%]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"ab-zoi230410-10\">\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>The prevalence of UTI, bacteremia, and bacterial meningitis was lower for febrile infants who tested positive for SARS-CoV-2, particularly infants aged 29 to 60 days and those with normal IMs. These findings may help inform management of certain febrile infants who test positive for SARS-CoV-2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.13354","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T11:35:27Z","timestamp":1683891327000},"page":"e2313354","source":"Crossref","is-referenced-by-count":33,"title":["Prevalence of Urinary Tract Infection, Bacteremia, and Meningitis Among Febrile Infants Aged 8 to 60 Days With SARS-CoV-2"],"prefix":"10.1001","volume":"6","author":[{"given":"Paul L.","family":"Aronson","sequence":"first","affiliation":[{"name":"Section of Pediatric Emergency Medicine, Departments of Pediatrics and of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P.","family":"Louie","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, University of Minnesota, Masonic Children's Hospital, 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