{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:47:59Z","timestamp":1792194479930,"version":"4.4.0"},"reference-count":54,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>People with serious mental illness (SMI), defined as a diagnosis of schizophrenia spectrum disorder, bipolar disorder, or disabling major depressive disorder) die approximately 10 to 25 years earlier than the general population.<\/jats:p><\/jats:sec>Objective<\/jats:title>To develop the first-ever lived experience\u2013led research agenda to address early mortality in people with SMI.<\/jats:p><\/jats:sec>Evidence Review<\/jats:title>A virtual 2-day roundtable comprising 40 individuals convened on May 24 and May 26, 2022, and used a virtual Delphi method to arrive at expert group consensus. Participants responded to 6 rounds of virtual Delphi discussion via email that prioritized research topics and agreement on recommendations. The roundtable was composed of individuals with lived experience of mental health and\/or substance misuse, peer support specialists, recovery coaches, parents and caregivers of people with SMI, researchers and clinician-scientists with and without lived experience, policy makers, and patient-led organizations. Twenty-two of 28 (78.6%) of the authors who provided data represented people with lived experiences. Roundtable members were selected by reviewing the peer-reviewed and gray literature on early mortality and SMI, direct email, and snowball sampling.<\/jats:p><\/jats:sec>Findings<\/jats:title>The following recommendations are presented in order of priority as identified by the roundtable participants: (1) improve the empirical understanding of the direct and indirect social and biological contributions of trauma on morbidity and early mortality; (2) advance the role of family, extended families, and informal supporters; (3) recognize the importance of co-occurring disorders and early mortality; (4) redefine clinical education to reduce stigma and support clinicians through technological advancements to improve diagnostic accuracy; (5) examine outcomes meaningful to people with an SMI diagnosis, such as loneliness and sense of belonging, and stigma and their complex relationship with early mortality; (6) advance the science of pharmaceuticals, drug discovery, and choice in medication use; (7) use precision medicine to inform treatment; and (8) redefine the terms system literacy<\/jats:italic> and health literacy.<\/jats:italic><\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>The recommendations of this roundtable are a starting point for changing practice and highlighting lived experience\u2013led research priorities as an option to move the field forward.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.15479","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T15:31:21Z","timestamp":1685115081000},"page":"e2315479","source":"Crossref","is-referenced-by-count":20,"title":["Lived Experience\u2013Led Research Agenda to Address Early Death in People With a Diagnosis of a Serious Mental Illness"],"prefix":"10.1001","volume":"6","author":[{"given":"Karen L.","family":"Fortuna","sequence":"first","affiliation":[{"name":"Geisel School of Medicine, Department of Psychiatry, Dartmouth College; Concord, New Hampshire"},{"name":"Collaborative Design for Recovery and Health, Nashua, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Lebby","sequence":"additional","affiliation":[{"name":"Collaborative Design for Recovery and Health, Nashua, New Hampshire"},{"name":"College of Nursing and Health Sciences, The University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Geiger","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine, Department of Psychiatry, Dartmouth College; 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