{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T10:10:03Z","timestamp":1685614203747},"reference-count":17,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>There is some evidence that men may be at higher risk of depression directly following the birth of their child and that approximately 1 in 10 men will experience depression in the year after birth, but less is known about men\u2019s antidepressant treatment during this time. Likewise, few direct comparisons have been made with antidepressant treatment in men who have not recently become fathers.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To determine whether recently having a child was associated with increased odds of antidepressant treatment in men.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study used UK primary care electronic health records from the IQVIA Medical Research Database. Participants included men aged 15 to 55 years who had had a child in the previous year, from January 2007 to December 2016, and compared with up to 5 men who did not have a child in the same calendar year. Data were analyzed from January 2022 to March 2023.<\/jats:p><\/jats:sec>Exposure<\/jats:title>A record of having a child in the previous year was identified through linked primary care records using a family identification number.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The main outcome was antidepressant initiation in the year after childbirth or in the year after this index date for men who did not have a child. Random-effects Poisson regression was used to determine associations of cohort, age group, social deprivation, history of antidepressant treatment, and calendar year with having an antidepressant prescription in the year after index date using prevalence risk rates (PPRs).<\/jats:p><\/jats:sec>Results<\/jats:title>Analysis included 90\u202f736 men who had had a child in the previous year and 453\u202f632 men in the comparison cohort. Most men in the study (463\u202f879 men [85.2%]) were aged between 25 and 44 years, and there were more men living in the least deprived areas (130\u202f277 men [23.9%]) than the most deprived areas (72\u202f268 men [13.3%]). Overall, 4439 men (4.9%) had at least 1 antidepressant prescription in the year after they had a child, compared with 26\u202f646 men (5.9%) who did not have a child in the same year. However, after adjustment there was no difference in antidepressant treatment between groups (adjusted PRR [aPRR], 1.01; 95% CI, 0.98-1.04). In fathers, those who had recently received antidepressant treatment were much more likely to receive antidepressant treatment after childbirth compared with fathers with no history of antidepressant treatment (aPRR, 32.31; 95% CI, 30.37-34.38). Fathers living in the most deprived areas were 18% more likely to have an antidepressant prescription compared with fathers living in the least deprived areas (aPRR, 1.18; 95% CI, 1.07-1.30).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>These findings suggest that recently having a child was not associated with an increase in antidepressant treatment among men, but previous antidepressant treatment in fathers was strongly associated with treatment after childbirth. Further research is needed to determine whether antidepressant treatment or experiencing depression can be a barrier to fatherhood and whether fatherhood is a barrier to receiving antidepressant treatment.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.16105","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T15:33:31Z","timestamp":1685547211000},"page":"e2316105","source":"Crossref","is-referenced-by-count":0,"title":["Association of Recent Fatherhood With Antidepressant Treatment Initiation Among Men in the United Kingdom"],"prefix":"10.1001","volume":"6","author":[{"given":"Holly Christina","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Primary Care and Population Health, University College London, Royal Free Campus, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Petersen","sequence":"additional","affiliation":[{"name":"Epidemiology and Health Informatics, Department of Primary Care and Population Health, Institute of Epidemiology & Health, University College London, Free Campus, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Schartau","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health, University College London, Royal Free Campus, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"issue":"5","key":"zoi230489r2","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1192\/bjp.bp.115.166975","article-title":"Initiation and duration of selective serotonin reuptake inhibitor prescribing over time: UK cohort study.","volume":"209","author":"McCrea","year":"2016","journal-title":"Br J Psychiatry"},{"issue":"2","key":"zoi230489r3","first-page":"35","article-title":"Sad dads: paternal postpartum 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