{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:30:37Z","timestamp":1791595837304,"version":"4.3.4"},"reference-count":100,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Type 2 diabetes (T2D) is increasing globally. Diabetic retinopathy (DR) is a leading cause of blindness in adults with T2D; however, the global burden of DR in pediatric T2D is unknown. This knowledge can inform retinopathy screening and treatments to preserve vision in this population.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To estimate the global prevalence of DR in pediatric T2D.<\/jats:p>\n <\/jats:sec>\n \n Data Sources<\/jats:title>\n \n MEDLINE, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane Library, the Web of Science, and the gray literature (ie, literature containing information that is not available through traditional publishing and distribution channels) were searched for relevant records from the date of database inception to April 4, 2021, with updated searches conducted on May 17, 2022. Searches were limited to human studies. No language restrictions were applied. Search terms included\n diabetic retinopathy<\/jats:italic>\n ;\n diabetes mellitus, type 2<\/jats:italic>\n ;\n prevalence studies<\/jats:italic>\n ; and\n child<\/jats:italic>\n ,\n adolescent<\/jats:italic>\n ,\n teenage<\/jats:italic>\n ,\n youth<\/jats:italic>\n , and\n pediatric<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Study Selection<\/jats:title>\n Three teams, each with 2 reviewers, independently screened for observational studies with 10 or more participants that reported the prevalence of DR. Among 1989 screened articles, 27 studies met the inclusion criteria for the pooled analysis.<\/jats:p>\n <\/jats:sec>\n \n Data Extraction and Synthesis<\/jats:title>\n \n This systematic review and meta-analysis followed the Meta-analysis of Observational Studies in Epidemiology (MOOSE) and the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines for systematic reviews and meta-analyses. Two independent reviewers performed the risk of bias and level of evidence analyses. The results were pooled using a random-effects model, and heterogeneity was reported using \u03c7\n 2<\/jats:sup>\n and\n I<\/jats:italic>\n 2<\/jats:sup>\n statistics.\n <\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The main outcome was the estimated pooled global prevalence of DR in pediatric T2D. Other outcomes included DR severity and current DR assessment methods. The association of diabetes duration, sex, race, age, and obesity with DR prevalence was also assessed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among the 27 studies included in the pooled analysis (5924 unique patients; age range at T2D diagnosis, 6.5-21.0 years), the global prevalence of DR in pediatric T2D was 6.99% (95% CI, 3.75%-11.00%;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200995%; 615 patients). Fundoscopy was less sensitive than 7-field stereoscopic fundus photography in detecting retinopathy (0.47% [95% CI, 0%-3.30%;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090%] vs 13.55% [95% CI, 5.43%-24.29%;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200992%]). The prevalence of DR increased over time and was 1.11% (95% CI, 0.04%-3.06%;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20095%) at less than 2.5 years after T2D diagnosis, 9.04% (95% CI, 2.24%-19.55%;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200988%) at 2.5 to 5.0 years after T2D diagnosis, and 28.14% (95% CI, 12.84%-46.45%;\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200996%) at more than 5 years after T2D diagnosis. The prevalence of DR increased with age, and no differences were noted based on sex, race, or obesity. Heterogeneity was high among studies.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this study, DR prevalence in pediatric T2D increased significantly at more than 5 years after diagnosis. These findings suggest that retinal microvasculature is an early target of T2D in children and adolescents, and annual screening with fundus photography beginning at diagnosis offers the best assessment method for early detection of DR in pediatric patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.1887","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T11:00:47Z","timestamp":1679050847000},"page":"e231887","source":"Crossref","is-referenced-by-count":79,"title":["Global Prevalence of Diabetic Retinopathy in Pediatric Type 2 Diabetes"],"prefix":"10.1001","volume":"6","author":[{"given":"Milena","family":"Cioana","sequence":"first","affiliation":[{"name":"Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada"},{"name":"Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada"},{"name":"Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajantha","family":"Nadarajah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada"},{"name":"Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada"},{"name":"Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada"},{"name":"Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada"},{"name":"Michael G. De Groote School of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sondra Song Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada"},{"name":"Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Rivas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada"},{"name":"Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada"},{"name":"Michael G. De Groote School of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parm Pal","family":"Toor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada"},{"name":"Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Banfield","sequence":"additional","affiliation":[{"name":"Health Sciences Library, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lehana","family":"Thabane","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada"},{"name":"Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada"},{"name":"Centre for Evaluation of Medicines, St Joseph\u2019s Health Care, Hamilton, Ontario, Canada"},{"name":"Biostatistics Unit, St Joseph's Healthcare, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada"},{"name":"Division of Ophthalmology, Department of Surgery, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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