{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:04:19Z","timestamp":1788350659607,"version":"build-2803163510"},"reference-count":30,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Limited data exist on the association of gastroesophageal reflux (GER) symptoms with sleep quality.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To prospectively investigate the association between GER symptoms and sleep quality.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This prospective cohort study included data from the Nurses\u2019 Health Study II of female nurses in the US. Participants self-reported the frequency and duration of GER symptoms beginning June 2005, with updates every 4 years through June 2015. Follow-up was completed June 2019, and data were analyzed from November 15, 2022, to June 4, 2023.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n Frequency and duration of GER symptoms.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Poor sleep quality was assessed in 2017 through a modified Pittsburgh Sleep Quality Index, which included difficulty in falling asleep, restlessness of sleep, daytime sleepiness, sleep disturbance, and sleep duration. Relative risk (RR) for poor sleep quality and individual components of poor sleep quality was estimated according to the frequency and duration of GER symptoms.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 48\u202f536 women (median age, 59 years [range, 48-69 years]), 7929 (16.3%) developed poor sleep quality during 4 years of follow-up. Compared with those with GER symptoms less than once a month, the multivariable RR for poor sleep quality among women with GER symptoms more than once a week was 1.53 (95% CI, 1.45-1.62). Women who had GER symptoms once or more a week for more than 7 years had an RR of 1.36 (95% CI, 1.30-1.43) compared with women who had not had GER symptoms once or more a week. The frequency and duration of GER symptoms were significantly associated with each individual component of poor sleep quality; for example, the multivariable RRs for GER symptoms 2 or more times per week compared with no GER symptoms were 1.49 (95% CI, 1.39-1.58) for difficulty in falling asleep, 1.47 (95% CI, 1.39-1.56) for excessive daytime sleepiness, and 1.44 (95% CI, 1.36-1.53) for restlessness of sleep.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this prospective cohort study of female nurses in the Nurses\u2019 Health Study II, the frequency and duration of GER symptoms were associated with subsequent risk of poor sleep quality. The findings suggest that effective treatment of GER disease may be important not only for improvement of symptoms but also for the reduction of comorbidities associated with poor sleep quality.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.24240","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T11:14:54Z","timestamp":1689765294000},"page":"e2324240","source":"Crossref","is-referenced-by-count":14,"title":["Assessment of Gastroesophageal Reflux Symptoms and Sleep Quality Among Women in the Nurses\u2019 Health Study II"],"prefix":"10.1001","volume":"6","author":[{"given":"Jane","family":"Ha","sequence":"first","affiliation":[{"name":"Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston"},{"name":"Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raaj S.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston"},{"name":"Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Cao","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, Missouri"},{"name":"Division of Gastroenterology, Department of Medicine, Washington University School of Medicine in St Louis, Missouri"},{"name":"Alvin J. Siteman Cancer Center, Washington University School of Medicine in St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Staller","sequence":"additional","affiliation":[{"name":"Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston"},{"name":"Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Chan","sequence":"additional","affiliation":[{"name":"Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston"},{"name":"Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston"},{"name":"Channing Division of Network Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"},{"name":"Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge"},{"name":"Department of Immunology and Infectious Diseases, Harvard T.H. 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