{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:30:12Z","timestamp":1793503812974,"version":"4.5.0"},"reference-count":47,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Emerging data suggest that the incidence of early-onset cancers, defined as cancers diagnosed in people younger than 50 years, is increasing, but updated data are limited.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To characterize the patterns in the incidence of early-onset cancers in the US from 2010 to 2019 and provide granular data on the cancers with the fastest-growing incidence rates.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This population-based cohort study analyzed data from 17 National Cancer Institute Surveillance, Epidemiology, and End Results registries from January 1, 2010, to December 31, 2019. Age-standardized incidence rates per 100\u202f000 people were extracted for early-onset cancers, with rates age adjusted to the US standard population. A total of 562\u202f145 patients with early-onset cancer between 2010 and 2019 were identified and included. Data were analyzed from October 16, 2022, to May 23, 2023.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Primary outcomes were incidence rates and descriptive epidemiological data for people younger than 50 years with cancer. The annual percentage change (APC) of the age-standardized incidence rate was estimated using the Joinpoint regression program.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 562\u202f145 patients (324 138 [57.7%] aged 40-49 years; 351 120 [62.5%] female) with early-onset cancer, 4565 (0.8%) were American Indian or Alaska Native, 54\u202f876 (9.8%) were Asian or Pacific Islander, 61\u202f048 (10.9%) were Black, 118\u202f099 (21.0%) were Hispanic, 314\u202f610 (56.0%) were White, and 8947 (1.6%) were of unknown race and\/or ethnicity. From 2010 to 2019, the age-standardized incidence rate of early-onset cancers increased overall (APC, 0.28%; 95% CI, 0.09%-0.47%;\n P<\/jats:italic>\n \u2009=\u2009.01) and in female individuals (APC, 0.67%; 95% CI, 0.39%-0.94%;\n P<\/jats:italic>\n \u2009=\u2009.001) but decreased in male individuals (APC, \u22120.37%; 95% CI, \u22120.51% to \u22120.22%;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001). In contrast, the age-standardized incidence rate of cancers in individuals aged 50 years and older decreased over the study period (APC, \u22120.87%; 95% CI, \u22121.06% to \u22120.67%;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001). In 2019, the highest number of incident cases of early-onset cancer were in the breast (n\u2009=\u200912\u202f649). From 2010 to 2019, gastrointestinal cancers had the fastest-growing incidence rates among all early-onset cancer groups (APC, 2.16%; 95% CI, 1.66%-2.67%;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001). Among gastrointestinal cancers, those with the fastest-growing incidence rates were in the appendix (APC,\u200915.61%; 95% CI, 9.21%-22.38%;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001), intrahepatic bile duct (APC, 8.12%; 95% CI, 4.94%-11.39%;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001), and pancreas (APC, 2.53%; 95% CI, 1.69%-3.38%;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this cohort study, the incidence rates of early-onset cancer increased from 2010 to 2019. Although breast cancer had the highest number of incident cases, gastrointestinal cancers had the fastest-growing incidence rates among all early-onset cancers. These data may be useful for the development of surveillance strategies and funding priorities.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.28171","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T11:01:27Z","timestamp":1692183687000},"page":"e2328171","source":"Crossref","is-referenced-by-count":212,"title":["Patterns in Cancer Incidence Among People Younger Than 50 Years in the US, 2010 to 2019"],"prefix":"10.1001","volume":"6","author":[{"given":"Benjamin","family":"Koh","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren Jun Hao","family":"Tan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng 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Mount Elizabeth Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Muthiah","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung N.","family":"Luu","sequence":"additional","affiliation":[{"name":"Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania"},{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, 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