{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:18:34Z","timestamp":1793164714962,"version":"4.5.0"},"reference-count":71,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi230947-4\"><jats:title>Importance<\/jats:title><jats:p>The rate of severe maternal morbidity (SMM) is continuously increasing in the US. Evidence regarding the associations of climate-related exposure, such as environmental heat, with SMM is lacking.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi230947-5\"><jats:title>Objective<\/jats:title><jats:p>To examine associations between long- and short-term maternal heat exposure and SMM.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi230947-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This retrospective population-based epidemiological cohort study took place at a large integrated health care organization, Kaiser Permanente Southern California, between January 1, 2008, and December 31, 2018. Data were analyzed from February to April 2023. Singleton pregnancies with data on SMM diagnosis status were included.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi230947-7\"><jats:title>Exposures<\/jats:title><jats:p>Moderate, high, and extreme heat days, defined as daily maximum temperatures exceeding the 75th, 90th, and 95th percentiles of the time series data from May through September 2007 to 2018 in Southern California, respectively. Long-term exposures were measured by the proportions of different heat days during pregnancy and by trimester. Short-term exposures were represented by binary variables of heatwaves with 9 different definitions (combining percentile thresholds with 3 durations; ie, \u22652, \u22653, and \u22654 consecutive days) during the last gestational week.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi230947-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>The primary outcome was SMM during delivery hospitalization, measured by 20 subconditions excluding blood transfusion. Discrete-time logistic regression was used to estimate associations with long- and short-term heat exposure. Effect modification by maternal characteristics and green space exposure was examined using interaction terms.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi230947-9\"><jats:title>Results<\/jats:title><jats:p>There were 3446 SMM cases (0.9%) among 403\u202f602 pregnancies (mean [SD] age, 30.3 [5.7] years). Significant associations were observed with long-term heat exposure during pregnancy and during the third trimester. High exposure (\u226580th percentile of the proportions) to extreme heat days during pregnancy and during the third trimester were associated with a 27% (95% CI, 17%-37%; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001) and 28% (95% CI, 17%-41%; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001) increase in risk of SMM, respectively. Elevated SMM risks were significantly associated with short-term heatwave exposure under all heatwave definitions. The magnitude of associations generally increased from the least severe (HWD1: daily maximum temperature &amp;amp;gt;75th percentile lasting for \u22652 days; odds ratio [OR], 1.32; 95% CI, 1.17-1.48; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001) to the most severe heatwave exposure (HWD9: daily maximum temperature &amp;amp;gt;95th percentile lasting for \u22654 days; OR, 2.39; 95% CI, 1.62-3.54; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001). Greater associations were observed among mothers with lower educational attainment (OR for high exposure to extreme heat days during pregnancy, 1.43; 95% CI, 1.26-1.63; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001) or whose pregnancies started in the cold season (November through April; OR, 1.37; 95% CI, 1.24-1.53; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi230947-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>In this retrospective cohort study, long- and short-term heat exposure during pregnancy was associated with higher risk of SMM. These results might have important implications for SMM prevention, particularly in a changing climate.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.32780","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T15:33:04Z","timestamp":1694100784000},"page":"e2332780","source":"Crossref","is-referenced-by-count":59,"title":["Analysis of Heat Exposure During Pregnancy and Severe Maternal Morbidity"],"prefix":"10.1001","volume":"6","author":[{"given":"Anqi","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Health, Program in Public Health, University of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Program in Public Health, University of California, Irvine"},{"name":"Institute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Avila","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Slezak","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Sacks","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena"},{"name":"Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Abatzoglou","sequence":"additional","affiliation":[{"name":"School of Engineering, University of California, Merced"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Molitor","sequence":"additional","affiliation":[{"name":"College of Public Health and Human Sciences, Oregon State University, Corvallis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu-Chiuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, University of Southern California, Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Benmarhnia","sequence":"additional","affiliation":[{"name":"Scripps Institution of Oceanography, University of California, San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darios","family":"Getahun","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena"},{"name":"Department of Health Systems Science, Kaiser Permanente Bernard J. 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