{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:01:23Z","timestamp":1792645283409,"version":"4.5.0"},"reference-count":55,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Neonates with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH) frequently experience seizures, which are associated with adverse outcomes. Efforts to rapidly identify seizures and reduce seizure burden may positively change neurologic and neurodevelopmental outcomes.<\/jats:p><\/jats:sec>Objective<\/jats:title>To describe the onset, treatment, and evolution of seizures in a large cohort of newborns with HIE during TH assisted by a telehealth model and remote neuromonitoring approach.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This was a prospective, observational, multicenter cohort study performed between July 2017 and December 2021 in 32 hospitals in Brazil. Participants were newborns with HIE meeting eligibility criteria and receiving TH. Data were analyzed from November 2022 to April 2023.<\/jats:p><\/jats:sec>Exposure<\/jats:title>Infants with HIE receiving TH were remotely monitored with 3-channel amplitude-integrated electroencephalography (aEEG) including raw tracing and video imaging, and bedside clinicians received assistance from trained neonatologists and neurologists.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Data on modified Sarnat examination, presence, timing and seizure type, aEEG background activity, sleep-wake cycling, and antiepileptic drugs used were collected. Descriptive statistical analysis was used with independent t<\/jats:italic> test, \u03c72<\/jats:sup>, Mann-Whitney test, and post hoc analyses applied for associations.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 872 cooled newborns were enrolled; the median (IQR) gestational age was 39 (38-40) weeks, 518 (59.4%) were male, and 59 (6.8%) were classified as having mild encephalopathy by modified Sarnat examination, 504 (57.8%) as moderate, and 180 (20.6%) as severe. Electrographic seizures were identified in 296 newborns (33.9%), being only electrographic in 213 (71.9%) and clinical followed by electroclinical uncoupling in 50 (16.9%). Early abnormal background activity had a significant association with seizures. Infants with flat trace had the highest rate of seizures (58 infants [68.2%]) and the greatest association with the incidence of seizures (odds ratio [OR], 12.90; 95% CI, 7.57-22.22) compared with continuous normal voltage. The absence of sleep-wake cycling was also associated with a higher occurrence of seizures (OR, 2.22; 95% CI, 1.67-2.96). Seizure onset was most frequent between 6 and 24 hours of life (181 infants [61.1%]); however, seizure occurred in 34 infants (11.5%) during rewarming. A single antiepileptic drug controlled seizures in 192 infants (64.9%). The first line antiepileptic drug was phenobarbital in 294 (99.3%).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this cohort study of newborns with HIE treated with TH, electrographic seizure activity occurred in 296 infants (33.9%) and was predominantly electrographic. Seizure control was obtained with a single antiepileptic drug in 192 infants (64.9%). These findings suggest neonatal neurocritical care can be delivered at remote limited resource hospitals due to innovations in technology and telehealth.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.43429","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T16:02:14Z","timestamp":1700064134000},"page":"e2343429","source":"Crossref","is-referenced-by-count":26,"title":["Remote Monitoring for Seizures During Therapeutic Hypothermia in Neonates With Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1001","volume":"6","author":[{"given":"Gabriel Fernando Todeschi","family":"Variane","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Protecting Brains and Saving Futures Organization, Clinical Research Department, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Dahlen","sequence":"additional","affiliation":[{"name":"Quantitative Sciences Unit, Stanford University School of Medicine, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Fabri Rodrigues","family":"Pietrobom","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Protecting Brains and Saving Futures Organization, Clinical Research Department, S\u00e3o Paulo, Brazil"},{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Pereira","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Protecting Brains and Saving Futures Organization, Clinical Research Department, S\u00e3o Paulo, Brazil"},{"name":"Pediatric Nursing Department, Escola Paulista de Enfermagem, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Protecting Brains and Saving Futures Organization, Clinical Research Department, S\u00e3o Paulo, Brazil"},{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Jenn\u00e9","family":"Mimica","sequence":"additional","affiliation":[{"name":"Protecting Brains and Saving Futures Organization, Clinical Research Department, S\u00e3o Paulo, Brazil"},{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie Salles","family":"Llaguno","sequence":"additional","affiliation":[{"name":"Protecting Brains and Saving Futures Organization, Clinical Research Department, S\u00e3o Paulo, Brazil"},{"name":"Pediatric Nursing Department, Escola Paulista de Enfermagem, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danieli Mayumi Kimura","family":"Leandro","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Protecting Brains and Saving Futures Organization, Clinical Research Department, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Natale","family":"Girotto","sequence":"additional","affiliation":[{"name":"Protecting Brains and Saving Futures Organization, Clinical Research Department, S\u00e3o Paulo, Brazil"},{"name":"Division of Neurosurgery, Associa\u00e7\u00e3o Paulista para o Desenvolvimento da Medicina, Hospital de Transplantes Euryclides de Jesus Zerbini, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Brito","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Protecting Brains and Saving Futures Organization, Clinical Research Department, S\u00e3o Paulo, Brazil"},{"name":"Division of Pediatric Neurology, Faculdade de Medicina Hospital das Cl\u00ednicas, Instituto da Crian\u00e7a, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisa Page","family":"Van Meurs","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children\u2019s Hospital Stanford, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"issue":"9730","key":"zoi231264r1","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1016\/S0140-6736(10)60549-1","article-title":"Global, regional, and national causes of child mortality in 2008: a systematic analysis.","volume":"375","author":"Black","year":"2010","journal-title":"Lancet"},{"issue":"1","key":"zoi231264r2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1552-6909.2012.01429.x","article-title":"Experiences of parents whose newborns undergo hypothermia treatment following perinatal asphyxia.","volume":"42","author":"Nassef","year":"2013","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"issue":"9462","key":"zoi231264r3","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/S0140-6736(05)71048-5","article-title":"4 million neonatal deaths: when? Where? Why?","volume":"365","author":"Lawn","year":"2005","journal-title":"Lancet"},{"issue":"3","key":"zoi231264r4","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1093\/ije\/dyl043","article-title":"Estimating the causes of 4 million neonatal deaths in the year 2000.","volume":"35","author":"Lawn","year":"2006","journal-title":"Int J Epidemiol"},{"issue":"6","key":"zoi231264r6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy.","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum Dev"},{"issue":"10053","key":"zoi231264r7","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","article-title":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.","volume":"388","author":"GBD 2015 Mortality and Causes of Death Collaborators","year":"2016","journal-title":"Lancet"},{"issue":"10063","key":"zoi231264r8","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1016\/S0140-6736(16)31593-8","article-title":"Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals.","volume":"388","author":"Liu","year":"2016","journal-title":"Lancet"},{"issue":"2","key":"zoi231264r9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0378-3782(91)90191-5","article-title":"Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants.","volume":"25","author":"Shankaran","year":"1991","journal-title":"Early Hum Dev"},{"issue":"3","key":"zoi231264r11","doi-asserted-by":"publisher","first-page":"F220","DOI":"10.1136\/adc.2008.148205","article-title":"Long-term outcome after neonatal hypoxic-ischaemic encephalopathy.","volume":"95","author":"de Vries","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"5","key":"zoi231264r12","doi-asserted-by":"publisher","first-page":"F380","DOI":"10.1136\/adc.2004.067520","article-title":"Neuropsychological and educational problems at school age associated with neonatal encephalopathy.","volume":"90","author":"Marlow","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"6","key":"zoi231264r13","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1001\/archpediatrics.2011.1772","article-title":"Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis.","volume":"166","author":"Tagin","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"4","key":"zoi231264r14","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.jpeds.2011.09.018","article-title":"Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy.","volume":"160","author":"Shankaran","year":"2012","journal-title":"J Pediatr"},{"issue":"2","key":"zoi231264r15","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes.","volume":"371","author":"Azzopardi","year":"2014","journal-title":"N Engl J Med"},{"issue":"9","key":"zoi231264r16","doi-asserted-by":"publisher","first-page":"e1273","DOI":"10.1016\/S2214-109X(21)00264-3","article-title":"Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh.","volume":"9","author":"Thayyil","year":"2021","journal-title":"Lancet Glob Health"},{"issue":"5","key":"zoi231264r17","doi-asserted-by":"publisher","first-page":"e1302","DOI":"10.1542\/peds.2014-3777","article-title":"Treating EEG seizures in hypoxic ischemic encephalopathy: a randomized controlled trial.","volume":"136","author":"Srinivasakumar","year":"2015","journal-title":"Pediatrics"},{"issue":"12","key":"zoi231264r18","doi-asserted-by":"publisher","first-page":"e735","DOI":"10.1542\/neo.19-12-e735","article-title":"International perspectives: hypothermic neuroprotection for neonatal encephalopathy in low- and middle-income countries: a new approach to an old problem.","volume":"19","author":"Montaldo","year":"2018","journal-title":"Neoreviews"},{"issue":"3","key":"zoi231264r19","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s12028-009-9324-7","article-title":"Neurocritical care for neonates.","volume":"12","author":"Glass","year":"2010","journal-title":"Neurocrit Care"},{"issue":"10","key":"zoi231264r20","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/S2352-4642(20)30239-X","article-title":"A machine-learning algorithm for neonatal seizure recognition: a multicentre, randomised, controlled trial.","volume":"4","author":"Pavel","year":"2020","journal-title":"Lancet Child Adolesc Health"},{"issue":"3","key":"zoi231264r21","doi-asserted-by":"publisher","first-page":"F187","DOI":"10.1136\/adc.2005.086314","article-title":"Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures.","volume":"93","author":"Murray","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"5","key":"zoi231264r22","doi-asserted-by":"crossref","DOI":"10.1016\/j.siny.2021.101273","article-title":"Bedside and laboratory neuromonitoring in neonatal encephalopathy.","volume":"26","author":"Chalak","year":"2021","journal-title":"Semin Fetal Neonatal Med"},{"issue":"1","key":"zoi231264r23","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/sj.jp.7200107","article-title":"Neonatal seizures: incidence, onset, and etiology by gestational age.","volume":"19","author":"Sheth","year":"1999","journal-title":"J Perinatol"},{"issue":"6","key":"zoi231264r24","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1097\/WNP.0b013e31823e96d7","article-title":"The American Clinical Neurophysiology Society\u2019s guideline on continuous electroencephalography monitoring in neonates.","volume":"28","author":"Shellhaas","year":"2011","journal-title":"J Clin Neurophysiol"},{"key":"zoi231264r25","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jpeds.2016.04.083","article-title":"Neonatal outcomes of very low birth weight and very preterm neonates: an international comparison.","volume":"177","author":"Shah","year":"2016","journal-title":"J Pediatr"},{"issue":"2","key":"zoi231264r26","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jped.2013.07.004","article-title":"Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injury.","volume":"90","author":"Toso","year":"2014","journal-title":"J Pediatr (Rio J)"},{"issue":"6","key":"zoi231264r27","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.clinph.2010.09.028","article-title":"Neonatal seizure recognition\u2013comparative study of continuous-amplitude integrated EEG versus short conventional EEG recordings.","volume":"122","author":"Frenkel","year":"2011","journal-title":"Clin Neurophysiol"},{"issue":"7","key":"zoi231264r28","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1111\/apa.2013.102.issue-7","article-title":"Accuracy of amplitude-integrated electroencephalography in the prediction of neurodevelopmental outcome in asphyxiated infants receiving hypothermia treatment.","volume":"102","author":"Cseko","year":"2013","journal-title":"Acta Paediatr"},{"issue":"10","key":"zoi231264r29","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1055\/s-0040-1721711","article-title":"How helpful is aEEG? Context and user experience matter.","volume":"39","author":"Sandoval Karamian","year":"2022","journal-title":"Am J Perinatol"},{"key":"zoi231264r30","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.755144","article-title":"Current status and future directions of neuromonitoring with emerging technologies in neonatal care.","volume":"9","author":"Variane","year":"2022","journal-title":"Front Pediatr"},{"issue":"1","key":"zoi231264r31","doi-asserted-by":"publisher","first-page":"e293","DOI":"10.1542\/peds.2015-1517","article-title":"Telemedicine: pediatric applications.","volume":"136","author":"Burke","year":"2015","journal-title":"Pediatrics"},{"issue":"1 Suppl 1","key":"zoi231264r32","first-page":"136","article-title":"Neonatal regionalization through telemedicine using a community-based research and education core facility.","volume":"20","author":"Hall","year":"2010","journal-title":"Ethn Dis"},{"issue":"1","key":"zoi231264r33","first-page":"3","article-title":"Interfaz cerebro ordenador BCI mediante el uso de Emotiv Insight.","volume":"9","author":"M\u00e9ndez","year":"2019","journal-title":"Acta Nova"},{"issue":"11","key":"zoi231264r34","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2174\/157339631001140408115859","article-title":"Amplitude-integrated EEG and the newborn infant.","volume":"10","author":"Shah","year":"2014","journal-title":"Curr Pediatr Rev"},{"issue":"2","key":"zoi231264r36","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.1542\/neo.7-2-e76","article-title":"Amplitude-integrated EEG classification and interpretation in preterm and term infants.","volume":"7","author":"Hellstr\u00f6m-Westas","year":"2006","journal-title":"Neoreviews"},{"issue":"3","key":"zoi231264r37","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/epi.1988.29.issue-3","article-title":"Occult neonatal seizures.","volume":"29","author":"Clancy","year":"1988","journal-title":"Epilepsia"},{"issue":"9","key":"zoi231264r38","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.seizure.2013.05.006","article-title":"Acute neonatal encephalopathy and seizures recurrence: a combined aEEG\/EEG study.","volume":"22","author":"Mastrangelo","year":"2013","journal-title":"Seizure"},{"issue":"1","key":"zoi231264r39","doi-asserted-by":"publisher","first-page":"e131","DOI":"10.1542\/peds.2009-2938","article-title":"Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia.","volume":"126","author":"Thoresen","year":"2010","journal-title":"Pediatrics"},{"issue":"15","key":"zoi231264r40","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"issue":"6","key":"zoi231264r41","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1177\/0883073810390036","article-title":"Electrographic seizures during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy.","volume":"26","author":"Wusthoff","year":"2011","journal-title":"J Child Neurol"},{"issue":"3","key":"zoi231264r42","doi-asserted-by":"publisher","first-page":"F219","DOI":"10.1136\/archdischild-2013-305206","article-title":"Electrographic seizures are associated with brain injury in newborns undergoing therapeutic hypothermia.","volume":"99","author":"Shah","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"zoi231264r43","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.seizure.2015.09.014","article-title":"Amplitude-integrated EEG for detection of neonatal seizures: a systematic review.","volume":"33","author":"Rakshasbhuvankar","year":"2015","journal-title":"Seizure"},{"issue":"3","key":"zoi231264r44","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/jp.2016.206","article-title":"Changing antiepileptic drug use for seizures in US neonatal intensive care units from 2005 to 2014.","volume":"37","author":"Ahmad","year":"2017","journal-title":"J Perinatol"},{"issue":"2","key":"zoi231264r45","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.pediatrneurol.2011.11.006","article-title":"Neonatal seizures: treatment practices among term and preterm infants.","volume":"46","author":"Glass","year":"2012","journal-title":"Pediatr Neurol"},{"issue":"2","key":"zoi231264r46","first-page":"76","article-title":"Levetiracetam in neonatal seizures: a review.","volume":"20","author":"Mruk","year":"2015","journal-title":"J Pediatr Pharmacol Ther"},{"issue":"6","key":"zoi231264r47","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2019-3182","article-title":"Levetiracetam versus phenobarbital for neonatal seizures: a randomized controlled trial.","volume":"145","author":"Sharpe","year":"2020","journal-title":"Pediatrics"},{"issue":"2","key":"zoi231264r48","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1136\/archdischild-2020-318985","article-title":"Does the first hour of continuous electroencephalography predict neonatal seizures?","volume":"106","author":"Macdonald-Laurs","year":"2021","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"11","key":"zoi231264r49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165744","article-title":"Amplitude integrated electroencephalogram as a prognostic tool in neonates with hypoxic-ischemic encephalopathy: a systematic review.","volume":"11","author":"Del R\u00edo","year":"2016","journal-title":"PLoS One"},{"issue":"9460","key":"zoi231264r50","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial.","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"},{"issue":"2","key":"zoi231264r51","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/sj.jp.7211882","article-title":"Should amplitude-integrated electroencephalography be used to identify infants suitable for hypothermic neuroprotection?","volume":"28","author":"Sarkar","year":"2008","journal-title":"J Perinatol"},{"issue":"6","key":"zoi231264r52","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1097\/WNP.0000000000000730","article-title":"Expanding access to continuous EEG monitoring in neonatal intensive care units.","volume":"38","author":"Fitzgerald","year":"2021","journal-title":"J Clin Neurophysiol"},{"issue":"5","key":"zoi231264r53","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.ejpn.2011.03.001","article-title":"Recording conventional and amplitude-integrated EEG in neonatal intensive care unit.","volume":"15","author":"Neubauer","year":"2011","journal-title":"Eur J Paediatr Neurol"},{"issue":"2","key":"zoi231264r54","doi-asserted-by":"publisher","first-page":"e358","DOI":"10.1542\/peds.2009-0136","article-title":"Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial.","volume":"125","author":"van Rooij","year":"2010","journal-title":"Pediatrics"},{"issue":"12","key":"zoi231264r55","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.39604","article-title":"Effect of treatment of clinical seizures vs electrographic seizures in full-term and near-term neonates: a randomized clinical trial.","volume":"4","author":"Hunt","year":"2021","journal-title":"JAMA Netw Open"},{"key":"zoi231264r10","volume-title":"Fetal and neonatal brain injury","author":"Robertson","year":"2003","edition":"3rd ed"},{"key":"zoi231264r5","unstructured":"World Health Organization (WHO). The World Health Report 2005\u2014make every mother and child count. Accessed May 1, 2022. https:\/\/www.who.int\/publications\/i\/item\/9241562900"},{"key":"zoi231264r35","unstructured":"Marinho? TF. Recommendations of the Brazilian Society of Clinical Neurophysiology for electrodes position and EEG montage. In Portuguese. Brazilian Society of Clinical Neurophysiology. Accessed May 1, 2022. https:\/\/sbnc.org.br\/wp-content\/uploads\/2015\/05\/1512584738_Norma_montagens_EEG_.pdf"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2811869\/variane_2023_oi_231264_1699389629.9869.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T16:02:24Z","timestamp":1700064144000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2811869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,15]]},"references-count":55,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.43429","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,15]]}}}