{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:24:46Z","timestamp":1793330686512,"version":"4.5.0"},"reference-count":56,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Increasing evidence suggests that, compared with an omnivorous diet, a vegan diet confers potential cardiovascular benefits from improved diet quality (ie, higher consumption of vegetables, legumes, fruits, whole grains, nuts, and seeds).<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To compare the effects of a healthy vegan vs healthy omnivorous diet on cardiometabolic measures during an 8-week intervention.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This single-center, population-based randomized clinical trial of 22 pairs of twins (N\u2009=\u200944) randomized participants to a vegan or omnivorous diet (1 twin per diet). Participant enrollment began March 28, 2022, and continued through May 5, 2022. The date of final follow-up data collection was July 20, 2022. This 8-week, open-label, parallel, dietary randomized clinical trial compared the health impact of a vegan diet vs an omnivorous diet in identical twins. Primary analysis included all available data.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n Twin pairs were randomized to follow a healthy vegan diet or a healthy omnivorous diet for 8 weeks. Diet-specific meals were provided via a meal delivery service from baseline through week 4, and from weeks 5 to 8 participants prepared their own diet-appropriate meals and snacks.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n \n The primary outcome was difference in low-density lipoprotein cholesterol concentration from baseline to end point (week 8). Secondary outcome measures were changes in cardiometabolic factors (plasma lipids, glucose, and insulin levels and serum trimethylamine\n N<\/jats:italic>\n -oxide level), plasma vitamin B\n 12<\/jats:sub>\n level, and body weight. Exploratory measures were adherence to study diets, ease or difficulty in following the diets, participant energy levels, and sense of well-being.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 22 pairs (N\u2009=\u200944) of twins (34 [77.3%] female; mean [SD] age, 39.6 [12.7] years; mean [SD] body mass index, 25.9 [4.7]) were enrolled in the study. After 8 weeks, compared with twins randomized to an omnivorous diet, the twins randomized to the vegan diet experienced significant mean (SD) decreases in low-density lipoprotein cholesterol concentration (\u221213.9 [5.8] mg\/dL; 95% CI, \u221225.3 to \u22122.4 mg\/dL), fasting insulin level (\u22122.9 [1.3] \u03bcIU\/mL; 95% CI, \u22125.3 to \u22120.4 \u03bcIU\/mL), and body weight (\u22121.9 [0.7] kg; 95% CI, \u22123.3 to \u22120.6 kg).<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this randomized clinical trial of the cardiometabolic effects of omnivorous vs vegan diets in identical twins, the healthy vegan diet led to improved cardiometabolic outcomes compared with a healthy omnivorous diet. Clinicians can consider this dietary approach as a healthy alternative for their patients.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n ClinicalTrials.gov Identifier:\n NCT05297825<\/jats:ext-link>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.44457","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T11:31:32Z","timestamp":1701343892000},"page":"e2344457","source":"Crossref","is-referenced-by-count":112,"title":["Cardiometabolic Effects of Omnivorous vs Vegan Diets in Identical Twins"],"prefix":"10.1001","volume":"6","author":[{"given":"Matthew J.","family":"Landry","sequence":"first","affiliation":[{"name":"Stanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Palo Alto, California"},{"name":"Department of Population Health and Disease Prevention, Program in Public Health, University of California, 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