{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:09:42Z","timestamp":1791378582054,"version":"4.3.2"},"reference-count":21,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Poor ovarian response (POR) to stimulation may impact patients\u2019 desire or need to utilize cryopreserved oocytes for family building in the future. These findings, captured by Society for Assisted Reproductive Technology (SART) national data, underscore the need for tailored counseling and further research into the decision-making processes influencing oocyte utilization.<\/jats:p><\/jats:sec>Objective<\/jats:title>To examine the association of ovarian response to stimulation and the number of vitrified oocytes with the likelihood and timing of patients returning for oocyte utilization following planned oocyte cryopreservation (OC).<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study used data in the SART Clinical Outcome Reporting System for patients in US fertility clinics and data was used for eligible patients who underwent planned OC from January 2014 through December 2020. Data were analyzed from November 2022 to June 2023.<\/jats:p><\/jats:sec>Main outcomes and measures<\/jats:title>The association between number of oocytes cryopreserved on return rate to utilize cryopreserved oocytes and the time from vitrification to warming.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 67\u202f893 autologous oocyte freezing cycles were performed in the US between 2014 and 2020, among 47\u202f363 patients (mean [SD] age, 34.5 [4.7] years). Of these, 6421 (13.5%) were classified as patients with POR, with fewer than 5 oocytes vitrified across all ovarian stimulation cycles. A total of 1203 patients (2.5%) returned for oocyte warming and utilization. The rate of return was significantly higher in the POR group, with 260 (4.0%) returning compared with 943 (2.3%) in the normal responder group (P<\/jats:italic>\u2009&amp;lt;\u2009.001). This trend was most notable in the age 30 to 34 years (warm cycle, 46 of 275 [16.7%] vs no warm cycle, 982 of 11\u202f743 [8.4%]; P<\/jats:italic>\u2009&amp;lt;\u2009.001) and age 35 to 39 years groups (warm cycle, 124 of 587 [21.1%] vs no warm cycle, 3433 of 23\u202f012 [14.9%]; P<\/jats:italic>\u2009&amp;lt;\u2009.001). The time elapsed from vitrification to warming was comparable between patients with POR (mean [SD], 716.1 [156.1] days) and normal responders (803.8 [160.7] days). A multivariate analysis adjusted for age, clinic region in the US, body mass index, and history of endometriosis was conducted to identify factors associated with the utilization of oocytes. The analysis revealed that having fewer than 5 oocytes vitrified was associated with higher odds of utilizing oocytes (OR, 1.52; 95% CI, 1.32-1.76).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>This cohort study reveals a distinct pattern in the utilization of cryopreserved oocytes among patients undergoing planned OC in the US. Despite the increase in number of patients pursuing OC, there is a notably low rate of return to utilize previously vitrified oocytes; notably, patients with POR are more likely to return, although the time to return is similar to those with normal ovarian response.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.49722","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T16:01:54Z","timestamp":1704211314000},"page":"e2349722","source":"Crossref","is-referenced-by-count":10,"title":["Utilization of Cryopreserved Oocytes in Patients With Poor Ovarian Response After Planned Oocyte Cryopreservation"],"prefix":"10.1001","volume":"7","author":[{"given":"Yuval","family":"Fouks","sequence":"first","affiliation":[{"name":"Boston IVF-The Eugin Group, Waltham, Massachusetts"},{"name":"Harvard T.H. Chan School of Public Health, Boston, Massachusetts"},{"name":"The Faculty of Medicine Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denny","family":"Sakkas","sequence":"additional","affiliation":[{"name":"Boston IVF-The Eugin Group, Waltham, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro E.","family":"Bortoletto","sequence":"additional","affiliation":[{"name":"Boston IVF-The Eugin Group, Waltham, Massachusetts"},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Penzias","sequence":"additional","affiliation":[{"name":"Boston IVF-The Eugin Group, Waltham, Massachusetts"},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Seidler","sequence":"additional","affiliation":[{"name":"Boston IVF-The Eugin Group, Waltham, Massachusetts"},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis A.","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Boston IVF-The Eugin Group, Waltham, Massachusetts"},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"issue":"7","key":"zoi231448r1","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1016\/j.fertnstert.2013.01.134","article-title":"Elective single embryo transfer trends and predictors of a good perinatal outcome\u2013United States, 1999 to 2010.","volume":"99","author":"Steinberg","year":"2013","journal-title":"Fertil Steril"},{"issue":"11","key":"zoi231448r2","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1093\/humrep\/dew232","article-title":"Population trends and live birth rates associated with common ART treatment strategies.","volume":"31","author":"Chambers","year":"2016","journal-title":"Hum Reprod"},{"issue":"6","key":"zoi231448r3","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1097\/MED.0000000000000291","article-title":"Elective oocyte cryopreservation for deferred childbearing.","volume":"23","author":"Goldman","year":"2016","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"2","key":"zoi231448r4","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.rbmo.2018.11.003","article-title":"Reconceiving egg freezing: insights from an analysis of 5 years of data from a UK clinic.","volume":"38","author":"G\u00fcrtin","year":"2019","journal-title":"Reprod Biomed Online"},{"issue":"3","key":"zoi231448r5","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.fertnstert.2015.11.027","article-title":"Oocyte vitrification as an efficient option for elective fertility preservation.","volume":"105","author":"Cobo","year":"2016","journal-title":"Fertil Steril"},{"issue":"3","key":"zoi231448r6","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1093\/humrep\/deaa320","article-title":"A major increase in oocyte cryopreservation cycles in the USA, Australia and New Zealand since 2010 is highlighted by younger women but a need for standardized data collection.","volume":"36","author":"Johnston","year":"2021","journal-title":"Hum Reprod"},{"issue":"1","key":"zoi231448r7","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/bioe.v36.1","article-title":"Co-sponsored egg freezing: an offer you can\u2019t refuse?","volume":"36","author":"Petersen","year":"2022","journal-title":"Bioethics"},{"issue":"2","key":"zoi231448r8","doi-asserted-by":"publisher","first-page":"R42","DOI":"10.1530\/RAF-22-0008","article-title":"Long-term preservation of germ cells and gonadal tissues at ambient temperatures.","volume":"3","author":"Comizzoli","year":"2022","journal-title":"Reprod Fertil"},{"issue":"1","key":"zoi231448r9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12958-021-00884-0","article-title":"Oocyte cryopreservation review: outcomes of medical oocyte cryopreservation and planned oocyte cryopreservation.","volume":"20","author":"Walker","year":"2022","journal-title":"Reprod Biol Endocrinol"},{"key":"zoi231448r10","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ejogrb.2022.12.016","article-title":"Long term pregnancy outcomes of women with cancer following fertility preservation: a systematic review and meta-analysis.","volume":"281","author":"Xu","year":"2023","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"zoi231448r11","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s10815-023-02715-0","article-title":"Knowledge and attitude of reproductive-aged women towards planned oocyte cryopreservation in the United Arab Emirates.","volume":"40","author":"Sayegh","year":"2023","journal-title":"J Assist Reprod Genet"},{"issue":"6","key":"zoi231448r12","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1016\/j.fertnstert.2016.02.005","article-title":"A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept.","volume":"105","author":"Alviggi","year":"2016","journal-title":"Fertil Steril"},{"issue":"9","key":"zoi231448r13","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1093\/humrep\/deu139","article-title":"The Bologna criteria for the definition of poor ovarian responders: is there a need for revision?","volume":"29","author":"Ferraretti","year":"2014","journal-title":"Hum Reprod"},{"issue":"9","key":"zoi231448r14","doi-asserted-by":"publisher","first-page":"e113","DOI":"10.1111\/bjo.v127.9","article-title":"Elective oocyte freezing for non-medical reasons: scientific impact paper No. 63.","volume":"127","author":"Anderson","year":"2020","journal-title":"BJOG"},{"issue":"4","key":"zoi231448r15","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.fertnstert.2014.06.019","article-title":"Obstetric and perinatal outcome of babies born from vitrified oocytes.","volume":"102","author":"Cobo","year":"2014","journal-title":"Fertil Steril"},{"issue":"2","key":"zoi231448r17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/humupd\/dmp036","article-title":"Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART).","volume":"16","author":"La Marca","year":"2010","journal-title":"Hum Reprod Update"},{"issue":"7","key":"zoi231448r18","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1093\/humrep\/der092","article-title":"ESHRE consensus on the definition of \u2018poor response\u2019 to ovarian stimulation for in vitro fertilization: the Bologna criteria.","volume":"26","author":"Ferraretti","year":"2011","journal-title":"Hum Reprod"},{"issue":"12","key":"zoi231448r19","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1093\/humrep\/des318","article-title":"Live birth rates following natural cycle IVF in women with poor ovarian response according to the Bologna criteria.","volume":"27","author":"Polyzos","year":"2012","journal-title":"Hum Reprod"},{"issue":"4","key":"zoi231448r20","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.rbmo.2021.06.024","article-title":"Clinical outcomes and utilization from over a decade of planned oocyte cryopreservation.","volume":"43","author":"Leung","year":"2021","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"zoi231448r21","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.fertnstert.2022.04.013","article-title":"Fifteen years of autologous oocyte thaw outcomes from a large university-based fertility center.","volume":"118","author":"Cascante","year":"2022","journal-title":"Fertil Steril"},{"key":"zoi231448r16","unstructured":"What is SART. Society for Assisted Reproductive Technology. Accessed December 1, 2023. https:\/\/www.sart.org\/about-us\/what-is-sart\/"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2813453\/fouks_2024_oi_231448_1703019074.12965.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T16:01:58Z","timestamp":1704211318000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2813453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,2]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,2]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.49722","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,2]]}}}