{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:41:36Z","timestamp":1792680096025,"version":"4.5.0"},"reference-count":38,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Evidence regarding the effect of dietary niacin intake on the risk of mortality among patients with nonalcoholic fatty liver disease (NAFLD) is scarce.<\/jats:p><\/jats:sec>Objective<\/jats:title>To examine the association of dietary niacin intake with all-cause mortality and cardiovascular disease (CVD) mortality among individuals with NAFLD.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study used data from the National Health and Nutrition Examination Survey (2003-2018). In total, 4315 adults aged 20 years or older with NAFLD were included, with NAFLD defined using the United States Fatty Liver Index.<\/jats:p><\/jats:sec>Exposure<\/jats:title>Dietary niacin intake levels.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Weighted Cox proportional hazards models and restricted cubic splines were used to estimate hazard ratios and 95% CIs for all-cause and CVD mortality. Data were analyzed March 1 to September 1, 2023.<\/jats:p><\/jats:sec>Results<\/jats:title>This cohort study included data from 4315 participants in the analysis (mean [SD] age, 52.5 [16.2] years; 1670 participants \u226560 years [weighted, 30.9%]; 2351 men [weighted, 55.0%]). During a median (IQR) follow-up of 8.8 (4.6-11.8) years, 566 deaths were recorded, of which 197 were attributed to CVD. Compared with participants with a niacin intake of 18.4 mg or lower (the lowest tertile), the multivariable-adjusted hazard ratios for participants with a niacin intake of 26.7 mg or higher (the highest tertile) were 0.70 (95% CI, 0.50-0.96) for all-cause mortality (P<\/jats:italic>\u2009=\u2009.03 for trend) and 0.65 (95% CI, 0.35-1.20) for CVD mortality (P<\/jats:italic>\u2009=\u2009.16 for trend).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>Findings from this cohort study suggest that higher dietary niacin intake may be associated with lower risk of all-cause mortality among individuals with NAFLD. There was no evident inverse association between dietary niacin intake and the risk of CVD mortality.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.54277","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T16:32:36Z","timestamp":1706805156000},"page":"e2354277","source":"Crossref","is-referenced-by-count":43,"title":["Dietary Niacin Intake and Mortality Among Individuals With Nonalcoholic Fatty Liver Disease"],"prefix":"10.1001","volume":"7","author":[{"given":"Jie","family":"Pan","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen 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