{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T07:40:39Z","timestamp":1784446839526,"version":"3.55.0"},"reference-count":63,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Psychoeducational interventions (PEIs), which provide both information and emotional and psychosocial support, may address the unmet needs of the caregivers of adolescent and young adult patients with cancer.<\/jats:p><\/jats:sec>Objective<\/jats:title>To explore the effects of an instant messaging\u2013delivered PEI on anxiety, depression, quality of life (QOL), and coping and determine whether the intervention reduces caregivers\u2019 unmet needs.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This randomized clinical trial using an intention-to-treat protocol was conducted from April 1 to September 14, 2022, in a tertiary cancer hospital in China and included caregivers of patients diagnosed with cancer at age 15 to 39 years recruited using convenience sampling.<\/jats:p><\/jats:sec>Intervention<\/jats:title>Caregivers were allocated 1:1 using a randomized block scheme to the intervention or control group. The intervention group received a 5-week PEI and usual care, whereas the control group received only usual care. The PEI was delivered through articles and calls through an instant messaging application.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcomes were changes in the levels of caregivers\u2019 anxiety and depression, measured using the 7-Item Generalized Anxiety Disorder Scale and the Patient Health Questionnaire 9, respectively. The secondary outcomes were changes in the levels of caregivers\u2019 QOL, coping, and unmet needs.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 160 participants, 92 (57.5%) were male; mean (SD) age was 40.27 (8.33) years. Compared with the control group, the intervention group had significantly greater reduction in severity of anxiety (B\u2009=\u2009\u22123.231; 95% CI, \u22124.746 to \u22121.716; P<\/jats:italic>\u2009&amp;lt;\u2009.001) and depression (B\u2009=\u2009\u22123.253; 95% CI, \u22125.052 to \u22121.454; P<\/jats:italic>\u2009&amp;lt;\u2009.001), smaller reduction in QOL (B\u2009=\u200913.574; 95% CI, 0.488-26.661; P<\/jats:italic>\u2009=\u2009.04), and greater reduction in unmet needs (B\u2009=\u2009\u221212.136; 95% CI, \u221218.307 to \u22125.965; P<\/jats:italic>\u2009&amp;lt;\u2009.001) after the intervention. Twelve weeks after baseline, the intervention group demonstrated a significantly greater reduction only in severity of anxiety (B\u2009=\u2009\u22121.890; 95% CI, \u22123.382 to \u22120.397; P<\/jats:italic>\u2009=\u2009.01).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this randomized clinical trial of a mobile instant messaging\u2013delivered PEI, caregivers\u2019 unmet needs, anxiety, and depression decreased significantly and QOL declined at a significantly slower rate immediately after the intervention in the intervention group compared with the control group. A sustained effect on anxiety was observed 12 weeks after baseline.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>Chinese Clinical Trial Registry identifier: ChiCTR2200055951<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2023.56522","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T16:33:34Z","timestamp":1708619614000},"page":"e2356522","source":"Crossref","is-referenced-by-count":9,"title":["A Mobile Instant Messaging\u2013Delivered Psychoeducational Intervention for Cancer Caregivers"],"prefix":"10.1001","volume":"7","author":[{"given":"Qinqin","family":"Cheng","sequence":"first","affiliation":[{"name":"Hunan Cancer Hospital, Changsha, Hunan, China"},{"name":"Nethersole School of Nursing, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marques Shek Nam","family":"Ng","sequence":"additional","affiliation":[{"name":"Nethersole 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