{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:31:09Z","timestamp":1790346669331,"version":"4.1.0"},"reference-count":53,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Disturbances in maternal, placental, and fetal metabolism are associated with developmental outcomes. Associations of maternal, placental, and fetal metabolism with subsequent neurodevelopmental outcomes in the child are understudied.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate the metabolic associations within the maternal-placental-fetal unit and subsequent neurodevelopmental outcomes in younger siblings of children with autism spectrum disorder (ASD).<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This cohort study was conducted within a subset of the Markers of Autism Risk in Babies, Learning Early Signs (MARBLES) cohort. MARBLES is a prospective birth cohort of younger siblings of children with ASD assessed for neurodevelopmental outcomes at approximately age 36 months. Participants in MARBLES were recruited through the UC Davis MIND Institute. This subset of the MARBLES cohort included younger siblings born between 2009 and 2015. Maternal third trimester serum, placental tissue, and umbilical cord serum samples were collected from participants. Only pregnancies with at least 2 of these sample types were included in this analysis. Data analysis was conducted from March 1, 2023, to March 15, 2024.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n Quantitative metabolomics analysis was conducted on maternal third trimester serum, as well as placental tissue and umbilical cord serum collected at delivery.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Using the Autism Diagnostic Observation Schedule and Mullen Scales of Early Learning, outcomes were classified as ASD, other nontypical development (non-TD), and typical development (TD).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n This analysis included 100 maternal serum samples, 141 placental samples, and 124 umbilical cord serum samples from 152 pregnancies (median [IQR] maternal age, 34.6 [30.8-38.3] years; median [IQR] gestational age, 39.0 [38.6-39.7] weeks; 87 [57.2%] male infants). There was no evidence that the maternal third trimester serum metabolome was significantly associated with the other metabolomes. The placental and cord serum metabolomes were highly correlated (first latent variate pair:\n \n R\n 2<\/jats:sup>\n <\/jats:italic>\n \u2009=\u20090.75;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001) and the variate scores for each tissue were significantly associated with reduced risk of non-TD (placenta: relative risk [RR], 0.13; 95% CI, 0.02-0.71; cord: RR, 0.13; 95% CI, 0.03-0.70) but not ASD (placenta: RR, 1.09; 95% CI, 0.42-2.81; cord: RR, 0.63; 95% CI, 0.23-1.73) compared with the TD reference group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this cohort study of children with high familial risk of ASD, placental and cord serum metabolism at delivery were highly correlated. Furthermore, placental and cord serum metabolic profiles were associated with risk of non-TD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.13399","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T13:41:52Z","timestamp":1716903712000},"page":"e2413399","source":"Crossref","is-referenced-by-count":21,"title":["Neurodevelopment and Metabolism in the Maternal-Placental-Fetal Unit"],"prefix":"10.1001","volume":"7","author":[{"given":"Mariana","family":"Parenti","sequence":"first","affiliation":[{"name":"Department of Nutrition, University of California, Davis"},{"name":"Now with Center for Developmental Biology and Regenerative Medicine, Seattle Children\u2019s Research Institute, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of California, Davis"},{"name":"MIND Institute, University of California, Davis, Sacramento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Tancredi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, University of California, Davis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irva","family":"Hertz-Picciotto","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of California, Davis"},{"name":"MIND Institute, University of California, Davis, Sacramento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl K.","family":"Walker","sequence":"additional","affiliation":[{"name":"MIND Institute, University of California, Davis, Sacramento"},{"name":"Department of Obstetrics & Gynecology, School of Medicine, University of California, Davis, Sacramento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn 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