{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:31:14Z","timestamp":1792693874855,"version":"4.5.0"},"reference-count":48,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Moyamoya disease (MMD) is a rare chronic cerebrovascular disease, and the outcomes of bypass management in adult patients remain controversial.<\/jats:p><\/jats:sec>Objective<\/jats:title>To categorize adult MMD based on asymptomatic, ischemic, and hemorrhagic onset and compare the outcomes (death, hemorrhagic stroke [HS], and ischemic stroke [IS]) of bypass surgery (direct or indirect) with those of conservative management.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This retrospective, nationwide, population-based longitudinal cohort study used Korean National Health Insurance Research data to identify adults (aged \u226515 years) with MMD who were diagnosed between January 1, 2008, and December 31, 2020, and followed up until December 31, 2021 (median follow-up, 5.74 [IQR, 2.95-9.42] years). A total of 19\u202f700 participants (3194 with hemorrhagic, 517 with ischemic, and 15\u202f989 with asymptomatic MMD) were included. Data were analyzed from January 2 to April 1, 2023.<\/jats:p><\/jats:sec>Exposures<\/jats:title>Bypass surgery and conservative management.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Death constituted the primary outcome; secondary outcomes consisted of HS or IS. Kaplan-Meier survival curve and Cox proportional hazards regression analysis were applied. The propensity score\u2013matching and stratified analyses were performed to control covariate effects.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 19\u202f700 patients (mean [SD] age, 45.43 [14.98] years; 12\u202f766 [64.8%] female) were included. Compared with conservative management, bypass was associated with a reduced risk of death (adjusted hazard ratio [AHR], 0.50 [95% CI, 0.41-0.61]; P<\/jats:italic>\u2009&amp;lt;\u2009.001) and HS (AHR, 0.36 [0.30-0.40]; P<\/jats:italic>\u2009&amp;lt;\u2009.001) in hemorrhagic MMD; reduced risk of IS (AHR, 0.55 [95% CI, 0.37-0.81]; P<\/jats:italic>\u2009=\u2009.002) in ischemic MMD; and reduced risk of death (AHR, 0.74 [95% CI, 0.66-0.84]; P<\/jats:italic>\u2009&amp;lt;\u2009.001) in asymptomatic MMD. However, bypass was associated with an increased risk of HS (AHR, 1.76 [95% CI, 1.56-2.00]; P<\/jats:italic>\u2009&amp;lt;\u2009.001) in asymptomatic MMD. Both direct and indirect bypass demonstrated similar effects in hemorrhagic and asymptomatic MMD, except only direct bypass was associated with a reduced risk of IS (AHR, 0.52 [95% CI, 0.33- 0.83]; P<\/jats:italic>\u2009=\u2009.01) in ischemic MMD. After stratification, bypass was associated with a reduced risk of death in patients younger than 55 years with ischemic (AHR, 0.34 [95% CI, 0.13- 0.88]; P<\/jats:italic>\u2009=\u2009.03) and asymptomatic (AHR, 0.69 [95% CI, 0.60-0.79]; P<\/jats:italic>\u2009&amp;lt;\u2009.001) MMD, but an increased risk of HS in patients 55 years or older with ischemic MMD (AHR, 2.13 [95% CI, 1.1-4.16]; P<\/jats:italic>\u2009=\u2009.03).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>The findings of this cohort study of bypass outcomes for patients with MMD emphasize the importance of tailoring management strategies in adult patients based on onset types.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.15102","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T15:33:21Z","timestamp":1717688001000},"page":"e2415102","source":"Crossref","is-referenced-by-count":32,"title":["Outcomes of Bypass Surgery in Adult Moyamoya Disease by Onset 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