{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:25:20Z","timestamp":1789698320779,"version":"4.0.1"},"reference-count":97,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Racial discrimination increases the risk of adverse brain health outcomes, potentially via neuroplastic changes in emotion processing networks. The involvement of deep brain regions (brainstem and midbrain) in these responses is unknown. Potential associations of racial discrimination with alterations in deep brain functional connectivity and accelerated epigenetic aging, a process that substantially increases vulnerability to health problems, are also unknown.<\/jats:p><\/jats:sec>Objective<\/jats:title>To examine associations of racial discrimination with brainstem and midbrain resting-state functional connectivity (RSFC) and DNA methylation age acceleration (DMAA) among Black women in the US.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study was conducted between January 1, 2012, and February 28, 2015, and included a community-based sample of Black women (aged \u226518 years) recruited as part of the Grady Trauma Project. Self-reported racial discrimination was examined in association with seed-to-voxel brain connectivity, including the locus coeruleus (LC), periaqueductal gray (PAG), and superior colliculus (SC); an index of DMAA (Horvath clock) was also evaluated. Posttraumatic stress disorder (PTSD), trauma exposure, and age were used as covariates in statistical models to isolate racial discrimination\u2013related variance. Data analysis was conducted between January 10 and October 30, 2023.<\/jats:p><\/jats:sec>Exposure<\/jats:title>Varying levels of racial discrimination exposure, other trauma exposure, and posttraumatic stress disorder (PTSD).<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Racial discrimination frequency was assessed with the Experiences of Discrimination Scale, other trauma exposure was evaluated with the Traumatic Events Inventory, and current PTSD was evaluated with the PTSD Symptom Scale. Seed-to-voxel functional connectivity analyses were conducted with LC, PAG, and SC seeds. To assess DMAA, the Methylation EPIC BeadChip assay (Illumina) was conducted with whole-blood samples from a subset of 49 participants.<\/jats:p><\/jats:sec>Results<\/jats:title>This study included 90 Black women, with a mean (SD) age of 38.5 (11.3) years. Greater racial discrimination was associated with greater left LC RSFC to the bilateral precuneus (a region within the default mode network implicated in rumination and reliving of past events; cluster size k<\/jats:italic>\u2009=\u2009228; t<\/jats:italic>85<\/jats:sub>\u2009=\u20094.78; P<\/jats:italic>\u2009&amp;lt;\u2009.001, false discovery rate-corrected). Significant indirect effects were observed for the left LC-precuneus RSFC on the association between racial discrimination and DMAA (\u03b2 [SE]\u2009=\u20090.45 [0.16]; 95% CI, 0.12-0.77).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this study, more frequent racial discrimination was associated with proportionately greater RSFC of the LC to the precuneus, and these connectivity alterations were associated with DMAA. These findings suggest that racial discrimination contributes to accelerated biological aging via altered connectivity between the LC and default mode network, increasing vulnerability for brain health problems.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.16588","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T15:22:30Z","timestamp":1718292150000},"page":"e2416588","source":"Crossref","is-referenced-by-count":26,"title":["Racial Discrimination, Neural Connectivity, and Epigenetic Aging Among Black Women"],"prefix":"10.1001","volume":"7","author":[{"given":"Aziz","family":"Elbasheir","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyma","family":"Katrinli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanne E.","family":"Kearney","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada"},{"name":"Department of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A.","family":"Lanius","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel G.","family":"Harnett","sequence":"additional","affiliation":[{"name":"Division of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sierra E.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Psychology, Georgia State University, Atlanta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Ely","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bekh","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia"},{"name":"Atlanta Veterans Affairs Medical Center, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Lori","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne J. 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