{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:16:15Z","timestamp":1785885375710,"version":"3.56.0"},"reference-count":43,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>The associations between angiographic findings and post\u2013percutaneous coronary intervention (PCI) fractional flow reserve (FFR) and their clinical relevance according to residual functional disease burden have not been thoroughly investigated.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To evaluate the association of angiographic and physiologic parameters according to residual functional disease burden after drug-eluting stent implantation.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study population was from the International Post-PCI FFR registry, which incorporated 4 registries from Korea, China, and Japan. Patients who underwent angiographically successful second-generation drug-eluting stent implantation and post-PCI FFR measurement were included in the analysis. The patients were divided into 3 groups according to the residual disease burden (post-PCI FFR \u22640.80 [residual ischemia], 0.81-0.86 [suboptimal], and &amp;gt;0.86 [optimal]). The data were collected from August 23, 2018, to June 11, 2019, and the current analysis was performed from January 11, 2022, to October 7, 2023.<\/jats:p><\/jats:sec>Exposures<\/jats:title>Angiographic parameters and post-PCI FFR.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcome was target vessel failure (TVF), defined as a composite of cardiac death, target vessel\u2013related myocardial infarction, and target vessel revascularization (TVR) at 2 years.<\/jats:p><\/jats:sec>Results<\/jats:title>In this cohort of 2147 patients, the mean (SD) age was 64.3 (10.0) years, and 1644 patients (76.6%) were men. Based on the post-PCI physiologic status, 269 patients (12.5%) had residual ischemia, 551 (25.7%) had suboptimal results, and 1327 (61.8%) had optimal results. Angiographic parameters had poor correlations with post-PCI FFR (r<\/jats:italic> &amp;lt; 0.20). Post-PCI FFR was isolated from all angiographic parameters in the unsupervised hierarchical cluster analysis. Post-PCI FFR was associated with the occurrence of TVF (adjusted hazard ratio [AHR] per post-PCI FFR 0.01 increase, 0.94 [95% CI, 0.92-0.97]; P<\/jats:italic>\u2009&amp;lt;\u2009.001), but angiographic parameters were not. The residual ischemia group had a significantly higher rate of TVF than the suboptimal group (AHR, 1.75 [95% CI, 1.08-2.83]; P<\/jats:italic>\u2009=\u2009.02) and the optimal group (AHR, 2.94 [95% CI, 1.82-4.73]; P<\/jats:italic>\u2009&amp;lt;\u2009.001). The TVR in the residual ischemia group was predominantly associated with TVR in the nonstented segment (14 [53.8%]), unlike the other 2 groups (3 [10.0%] in the suboptimal group and 13 [30.2%] in the optimal group).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this cohort study of the International Post-PCI FFR registry, a low degree of associations were observed between angiographic and physiologic parameters after PCI. Post-PCI FFR, unlike angiographic parameters, was associated with clinical events and the distribution of clinical events. The current study supports the use of post-PCI FFR as a procedural quality metric and further prospective study is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.18072","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T15:35:36Z","timestamp":1718984136000},"page":"e2418072","source":"Crossref","is-referenced-by-count":8,"title":["Angiographic Findings and Post\u2013Percutaneous Coronary Intervention Fractional Flow Reserve"],"prefix":"10.1001","volume":"7","author":[{"given":"Jinlong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Second Affiliated Hospital of Zhejiang University School of Medicine, State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doyeon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiovascular Center, Seoul National 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