{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:30:43Z","timestamp":1792056643021,"version":"4.4.0"},"reference-count":14,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n The use of ex vivo normothermic organ perfusion has enabled the use of deceased after circulatory death (DCD) donors for heart transplants. However, compared with conventional brain death donation, DCD heart transplantation performed with ex vivo organ perfusion involves an additional period of warm and cold ischemia, exposing the allograft to multiple bouts of ischemia reperfusion injury and may contribute to the high rates of extracorporeal membrane oxygenation usage after DCD heart transplantation.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To assess whether the beating heart method of DCD heart transplantation is safe and whether it has an acceptable rate of extracorporeal membrane oxygenation use postoperatively.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This case series includes 10 patients with end-stage heart failure undergoing DCD heart transplantation at a single academic medical center from October 1, 2022, to August 3, 2023. Data were analyzed from October 2022 to August 2023.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n Using a beating heart method of implantation of the donor allograft.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The main outcome was primary graft dysfunction necessitating postoperative initiation of mechanical circulatory support. Survival and initiation of mechanical circulatory support were secondary outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In this case series, 10 consecutive patients underwent DCD heart transplantation via the beating heart method. Ten of 10 recipients were male (100%), the mean (SD) age was 51.2 (13.8) years, and 7 (70%) had idiopathic dilated cardiomyopathy. Ten patients (100%) survived, and 0 patients had initiation of extracorporeal membrane oxygenation postoperatively. No other mechanical circulatory support, including intra-aortic balloon pump, was initiated postoperatively. Graft survival was 100% (10 of 10 patients), and, at the time of publication, no patients have been listed for retransplantation.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this study of 10 patients undergoing heart transplantation, the beating heart implantation method for DCD heart transplantation was safe and may mitigate ischemia reperfusion injury, which may lead to lower rates of primary graft dysfunction necessitating extracorporeal membrane oxygenation. These results are relevant to institutions using DCD donors for heart transplantation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.1828","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T11:02:15Z","timestamp":1710154935000},"page":"e241828","source":"Crossref","is-referenced-by-count":34,"title":["Beating Heart Transplant Procedures Using Organs From Donors With Circulatory Death"],"prefix":"10.1001","volume":"7","author":[{"given":"Aravind","family":"Krishnan","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chawannuch","family":"Ruaengsri","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon A.","family":"Guenthart","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Shudo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Ward","family":"MacArthur","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hiesinger","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Joseph","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California"},{"name":"Department of Bioengineering, Stanford University School of Engineering, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"issue":"5","key":"zoi240092r1","doi-asserted-by":"publisher","first-page":"e307","DOI":"10.1016\/j.jtcvs.2019.09.080","article-title":"Increasing the United States heart transplant donor pool with donation after circulatory death.","volume":"159","author":"Jawitz","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"zoi240092r2","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jacc.2021.10.042","article-title":"Feasibility and potential impact of heart transplantation from adult donors after circulatory death.","volume":"79","author":"Madan","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"15","key":"zoi240092r3","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019655","article-title":"National trends in heart donor usage rates: are we efficiently transplanting more hearts?","volume":"10","author":"Dharmavaram","year":"2021","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"zoi240092r5","doi-asserted-by":"publisher","first-page":"S72","DOI":"10.1016\/j.healun.2022.01.165","article-title":"Expanding heart transplants from donors after circulatory death (DCD)\u2014results of the first randomized controlled trial using the organ care system.","volume":"41","author":"Schroder","year":"2022","journal-title":"J Heart Lung Transplant"},{"issue":"8","key":"zoi240092r6","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.healun.2023.03.006","article-title":"A national pilot of donation after circulatory death (DCD) heart transplantation within the United Kingdom.","volume":"42","author":"Messer","year":"2023","journal-title":"J Heart Lung Transplant"},{"key":"zoi240092r7","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.xjtc.2023.02.015","article-title":"First-in-human beating-heart transplant.","volume":"19","author":"Krishnan","year":"2023","journal-title":"JTCVS Tech"},{"issue":"3","key":"zoi240092r8","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/01.TP.0000437178.48174.db","article-title":"Donation after circulatory death: current practices, ongoing challenges, and potential improvements.","volume":"97","author":"Morrissey","year":"2014","journal-title":"Transplantation"},{"issue":"5","key":"zoi240092r9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s11936-021-00906-5","article-title":"New approaches to donor selection and preparation in heart transplantation.","volume":"23","author":"Tong","year":"2021","journal-title":"Curr Treat Options Cardiovasc Med"},{"issue":"23","key":"zoi240092r10","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1056\/NEJMoa2212438","article-title":"Transplantation outcomes with donor hearts after circulatory death.","volume":"388","author":"Schroder","year":"2023","journal-title":"N Engl J Med"},{"issue":"12","key":"zoi240092r11","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/j.healun.2020.10.001","article-title":"A 5-year single-center early experience of heart transplantation from donation after circulatory-determined death donors.","volume":"39","author":"Messer","year":"2020","journal-title":"J Heart Lung Transplant"},{"issue":"4","key":"zoi240092r12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.005517","article-title":"Heart transplantation with donation after circulatory death.","volume":"12","author":"Niederberger","year":"2019","journal-title":"Circ Heart Fail"},{"issue":"4","key":"zoi240092r13","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nrcardio.2016.5","article-title":"Ischaemic conditioning and reperfusion injury.","volume":"13","author":"Hausenloy","year":"2016","journal-title":"Nat Rev Cardiol"},{"issue":"5","key":"zoi240092r14","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"zoi240092r4","unstructured":"Transmedics OCS. Transmedics. Accessed November 21, 2022. https:\/\/www.transmedics.com\/ocs-hcp\/"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2815867\/krishnan_2024_oi_240092_1772553181.80211.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:00:17Z","timestamp":1772726417000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2815867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,4]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.1828","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,11]]}}}