{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:45:18Z","timestamp":1791477918721,"version":"4.3.4"},"reference-count":44,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi240683-4\"><jats:title>Importance<\/jats:title><jats:p>Psoriasis is a common autoinflammatory disease influenced by complex interactions between environmental and genetic factors. The influence of long-term air pollution exposure on psoriasis remains underexplored.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi240683-5\"><jats:title>Objective<\/jats:title><jats:p>To examine the association between long-term exposure to air pollution and psoriasis and the interaction between air pollution and genetic susceptibility for incident psoriasis.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi240683-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This prospective cohort study used data from the UK Biobank. The analysis sample included individuals who were psoriasis free at baseline and had available data on air pollution exposure. Genetic analyses were restricted to White participants. Data were analyzed between November 1 and December 10, 2023.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi240683-7\"><jats:title>Exposures<\/jats:title><jats:p>Exposure to nitrogen dioxide (NO<jats:sub>2<\/jats:sub>), nitrogen oxides (NO<jats:sub>x<\/jats:sub>), fine particulate matter with a diameter less than 2.5 \u00b5m (PM<jats:sub>2.5<\/jats:sub>), and particulate matter with a diameter less than 10 \u00b5m (PM<jats:sub>10<\/jats:sub>) and genetic susceptibility for psoriasis.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi240683-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>To ascertain the association of long-term exposure to NO<jats:sub>2<\/jats:sub>, NO<jats:sub>x<\/jats:sub>, PM<jats:sub>2.5<\/jats:sub>, and PM<jats:sub>10<\/jats:sub>  with the risk of psoriasis, a Cox proportional hazards model with time-varying air pollution exposure was used. Cox models were also used to explore the potential interplay between air pollutant exposure and genetic susceptibility for the risk of psoriasis incidence.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi240683-9\"><jats:title>Results<\/jats:title><jats:p>A total of 474\u202f055 individuals were included, with a mean (SD) age of 56.54 (8.09) years and 257\u202f686 (54.36%) female participants. There were 9186 participants (1.94%) identified as Asian or Asian British, 7542 (1.59%) as Black or Black British, and 446\u202f637 (94.22%) as White European. During a median (IQR) follow-up of 11.91 (11.21-12.59) years, 4031 incident psoriasis events were recorded. There was a positive association between the risk of psoriasis and air pollutant exposure. For every IQR increase in PM<jats:sub>2.5<\/jats:sub>, PM<jats:sub>10<\/jats:sub>, NO<jats:sub>2<\/jats:sub>, and NO<jats:sub>x<\/jats:sub>, the hazard ratios (HRs) were 1.41 (95% CI, 1.35-1.46), 1.47 (95% CI, 1.41-1.52), 1.28 (95% CI, 1.23-1.33), and 1.19 (95% CI, 1.14-1.24), respectively. When comparing individuals in the lowest exposure quartile (Q1) with those in the highest exposure quartile (Q4), the multivariate-adjusted HRs were 2.01 (95% CI, 1.83-2.20) for PM<jats:sub>2.5<\/jats:sub>, 2.21 (95% CI, 2.02-2.43) for PM<jats:sub>10<\/jats:sub>, 1.64 (95% CI, 1.49-1.80) for NO<jats:sub>2<\/jats:sub>, and 1.34 (95% CI, 1.22-1.47) for NO<jats:sub>x<\/jats:sub>. Moreover, significant interactions between air pollution and genetic predisposition for incident psoriasis were observed. In the subset of 446\u202f637 White individuals, the findings indicated a substantial risk of psoriasis development in participants exposed to the highest quartile of air pollution levels concomitant with high genetic risk compared with those in the lowest quartile of air pollution levels with low genetic risk (PM<jats:sub>2.5<\/jats:sub>: HR, 4.11; 95% CI, 3.46-4.90; PM<jats:sub>10<\/jats:sub>: HR, 4.29; 95% CI, 3.61-5.08; NO<jats:sub>2<\/jats:sub>: HR, 2.95; 95% CI, 2.49-3.50; NO<jats:sub>x<\/jats:sub>: HR, 2.44; 95% CI, 2.08-2.87).<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi240683-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>In this prospective cohort study of the association between air pollution and psoriasis, long-term exposure to air pollution was associated with increased psoriasis risk. There was an interaction between air pollution and genetic susceptibility on psoriasis risk.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.21665","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T16:00:47Z","timestamp":1721145647000},"page":"e2421665","source":"Crossref","is-referenced-by-count":42,"title":["Exposure to Air Pollution, Genetic Susceptibility, and Psoriasis Risk in the UK"],"prefix":"10.1001","volume":"7","author":[{"given":"Junhui","family":"Wu","sequence":"first","affiliation":[{"name":"School of Nursing, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudiyang","family":"Ma","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 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