{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:59:09Z","timestamp":1793213949972,"version":"4.5.0"},"reference-count":29,"publisher":"American Medical Association (AMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Chronic symptoms reported following an infection with SARS-CoV-2, such as cognitive problems, overlap with symptoms included in the definition of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS).<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate the prevalence of ME\/CFS-like illness subsequent to acute SARS-CoV-2 infection, changes in ME\/CFS symptoms through 12 months of follow-up, and the association of ME\/CFS symptoms with SARS-CoV-2 test results at the acute infection\u2013like index illness.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This prospective, multisite, longitudinal cohort study (Innovative Support for Patients with SARS-CoV-2 Infections Registry [INSPIRE]) enrolled participants from December 11, 2020, to August 29, 2022. Participants were adults aged 18 to 64 years with acute symptoms suggestive of SARS-CoV-2 infection who received a US Food and Drug Administration\u2013approved SARS-CoV-2 test at the time of illness and did not die or withdraw from the study by 3 months. Follow-up surveys were collected through February 28, 2023.<\/jats:p><\/jats:sec>Exposure<\/jats:title>COVID-19 status (positive vs negative) at enrollment.<\/jats:p><\/jats:sec>Main Outcome and Measures<\/jats:title>The main outcome was the weighted proportion of participants with ME\/CFS-like illness based on the 2015 Institute of Medicine clinical case definition using self-reported symptoms.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 4378 participants were included in the study. Most were female (3226 [68.1%]). Mean (SD) age was 37.8 (11.8) years. The survey completion rates ranged from 38.7% (3613 of 4738 participants) to 76.3% (1835 of 4738) and decreased over time. The weighted proportion of participants identified with ME\/CFS-like illness did not change significantly at 3 through 12 months of follow-up and was similar in the COVID-19\u2013positive (range, 2.8%-3.7%) and COVID-19\u2013negative (range, 3.1%-4.5%) groups. Adjusted analyses revealed no significant difference in the odds of ME\/CFS-like illness at any time point between COVID-19\u2013positive and COVID-19\u2013negative individuals (marginal odds ratio range, 0.84 [95% CI, 0.42-1.67] to 1.18 [95% CI, 0.55-2.51]).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this prospective cohort study, there was no evidence that the proportion of participants with ME\/CFS-like illness differed between those infected with SARS-CoV-2 vs those without SARS-CoV-2 infection up to 12 months after infection. A 3% to 4% prevalence of ME\/CFS-like illness after an acute infection\u2013like index illness would impose a high societal burden given the millions of persons infected with SARS-CoV-2.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.23555","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T15:45:36Z","timestamp":1721835936000},"page":"e2423555","source":"Crossref","is-referenced-by-count":26,"title":["Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome After SARS-CoV-2 Infection"],"prefix":"10.1001","volume":"7","author":[{"given":"Elizabeth R.","family":"Unger","sequence":"first","affiliation":[{"name":"Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Mann S.","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of 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