{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:08:38Z","timestamp":1786975718959,"version":"build-2736575974"},"reference-count":25,"publisher":"American Medical Association (AMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n The development of an alcohol use disorder in adolescence is associated with increased risk of future alcohol dependence. The differential associations of risk factors with alcohol use over the course of 8 years are important for preventive measures.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To determine the differential associations of risk-taking aspects of personality, social factors, brain functioning, and familial risk with hazardous alcohol use in adolescents over the course of 8 years.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n The IMAGEN multicenter longitudinal cohort study included adolescents recruited from European schools in Germany, the UK, France, and Ireland from January 2008 to January 2019. Eligible participants included those with available neuropsychological, self-report, imaging, and genetic data at baseline. Adolescents who were ineligible for magnetic resonance imaging or had serious medical conditions were excluded. Data analysis was conducted from July 2021 to September 2022.<\/jats:p>\n <\/jats:sec>\n \n Exposure<\/jats:title>\n Personality testing, psychosocial factors, brain functioning, and familial risk of alcohol misuse.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome and Measures<\/jats:title>\n Hazardous alcohol use as measured with the Alcohol Use Disorders Identification Test scores, a main planned outcome of the IMAGEN study. Alcohol misuse trajectories at ages 14, 16, 19, and 22 years were modeled using latent growth curve models.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 2240 adolescents (1110 female [49.6%] and 1130 male [50.4%]) were included in the study. There was a significant negative association of psychosocial resources (\u03b2\u2009=\u2009\u22120.29; SE\u2009=\u20090.03;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001) with the general risk of alcohol misuse as well as a significant positive association of the risk-taking aspects of personality with the intercept (\u03b2\u2009=\u20090.19; SE\u2009=\u20090.04;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001). Furthermore, there were significant positive associations of the social domain (\u03b2\u2009=\u20090.13; SE\u2009=\u20090.02;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001) and the personality domain (\u03b2\u2009=\u20090.07; SE\u2009=\u20090.02;\n P<\/jats:italic>\n \u2009&amp;lt;\u2009.001) with trajectories of alcohol misuse development over time (slope). Family history of substance misuse was negatively associated with general risk of alcohol misuse (\u03b2\u2009=\u2009\u22120.04; SE\u2009=\u20090.02;\n P<\/jats:italic>\n \u2009=\u2009.045) and its development over time (\u03b2\u2009=\u2009\u22120.03; SE\u2009=\u20090.01;\n P<\/jats:italic>\n \u2009=\u2009.01). Brain functioning showed no significant association with intercept or slope of alcohol misuse in the model.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n The findings of this cohort study suggest known risk factors of adolescent drinking may contribute differentially to future alcohol misuse. This approach may inform more individualized preventive interventions.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.25114","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T11:31:21Z","timestamp":1723807881000},"page":"e2425114","source":"Crossref","is-referenced-by-count":6,"title":["Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence"],"prefix":"10.1001","volume":"7","author":[{"given":"Mira","family":"Tschorn","sequence":"first","affiliation":[{"name":"Division of Social and Preventive Medicine, Department of Sports and Health Sciences, Intrafaculty unit of Cognitive Sciences, Faculty of Human Science, and Faculty of Health Sciences Brandenburg, Research Area Services Research and e-Health, University of Potsdam, Potsdam, Germany"},{"name":"German Center for Mental Health (DZPG), Berlin and Potsdam, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Daedelow","sequence":"additional","affiliation":[{"name":"German Center for Mental Health (DZPG), Berlin and Potsdam, Germany"},{"name":"Department of Psychiatry and Psychotherapy Campus Charit\u00e9 Mitte, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, Berlin, Germany"},{"name":"Department of Psychology, Humboldt-University Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Szalek","sequence":"additional","affiliation":[{"name":"Division of Social and Preventive Medicine, Department of Sports and Health Sciences, Intrafaculty unit of Cognitive Sciences, Faculty of Human Science, and Faculty of Health Sciences Brandenburg, Research Area Services Research and e-Health, University of Potsdam, Potsdam, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Banaschewski","sequence":"additional","affiliation":[{"name":"German Center for Mental Health (DZPG), Berlin and Potsdam, Germany"},{"name":"Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun L. W.","family":"Bokde","sequence":"additional","affiliation":[{"name":"Discipline of Psychiatry, School of Medicine, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvane","family":"Desrivi\u00e8res","sequence":"additional","affiliation":[{"name":"Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic, and Developmental Psychiatry Centre, King\u2019s College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herta","family":"Flor","sequence":"additional","affiliation":[{"name":"Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"},{"name":"Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, 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