{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:16:27Z","timestamp":1793146587793,"version":"4.5.0"},"reference-count":32,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Cleft lip or palate is a prevalent birth defect, occurring in approximately 1 to 2 per 1000 newborns and often necessitating numerous hospitalizations. Specific rates of hospitalization and complication are underexplored.<\/jats:p><\/jats:sec>Objective<\/jats:title>To assess the rates of airway infection\u2013associated hospitalization, overall hospital admissions, in-hospital complications, and mortality among children with a cleft lip or palate.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This nationwide, population-based cohort study used in-hospital claims data from the Federal Statistical Office in Switzerland between 2012 and 2021. Participants included newborns with complete birth records born in a Swiss hospital. Data were analyzed from March to November 2023.<\/jats:p><\/jats:sec>Exposure<\/jats:title>Prevalent diagnosis of a cleft lip or palate at birth.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Outcomes of interest were monthly hospitalization rates for airway infections and any cause during the first 2 years of life in newborns with cleft lip or palate. In-hospital outcomes and mortality outcomes were also assessed, stratified by age and modality of surgical intervention.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 857\u202f806 newborns included, 1197 (0.1%) had a cleft lip and\/or palate, including 170 (14.2%) with a cleft lip only, 493 (41.2%) with a cleft palate only, and 534 (44.6%) with cleft lip and palate. Newborns with cleft lip or palate were more likely to be male (55.8% vs 51.4%), with lower birth weight (mean [SD] weight, 3135.6 [650.8] g vs 3284.7 [560.7] g) and height (mean [SD] height, 48.6 [3.8] cm vs 49.3 [3.2] cm). During the 2-year follow-up, children with a cleft lip or palate showed higher incidence rate ratios (IRRs) for hospitalizations due to airway infections (IRR, 2.33 [95% CI, 1.98-2.73]) and for any reason (IRR, 3.72 [95% CI, 3.49-3.97]) compared with controls. Additionally, children with cleft lip or palate had a substantial increase in odds of mortality (odds ratio [OR], 17.97 [95% CI, 11.84-27.29]) and various complications, including the need for intubation (OR, 2.37 [95% CI, 1.95-2.87]), extracorporeal membrane oxygenation (OR, 2.89 [95% CI, 1.81-4.63]), cardiopulmonary resuscitation (OR, 3.25 [95% CI, 2.21-4.78]), and respiratory support (OR, 1.94 [95% CI, 1.64-2.29]).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this nationwide cohort study, the presence of cleft lip or palate was associated with increased hospitalization rates for respiratory infections and other causes, as well as poorer in-hospital outcomes and greater resource use.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.28077","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T15:10:50Z","timestamp":1726153850000},"page":"e2428077","source":"Crossref","is-referenced-by-count":9,"title":["Hospitalization 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Switzerland"},{"name":"Department of Pediatrics, Kantonsspital Graub\u00fcnden, Chur, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Koehler","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Basel, Basel, Switzerland"},{"name":"Department of Pediatrics, Kantonsspital Aarau, Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schuetz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical University Clinic, Kantonsspital Aarau, Aarau, Switzerland"},{"name":"Faculty of Medicine, University of Basel, Basel, Switzerland"},{"name":"Department of Endocrinology and Diabetology, Medical University Clinic, Kantonsspital Aarau, Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Mueller","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Basel, Basel, Switzerland"},{"name":"Department of Endocrinology and Diabetology, Medical University Clinic, Kantonsspital Aarau, Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kutz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical University Clinic, Kantonsspital Aarau, Aarau, Switzerland"},{"name":"Faculty of Medicine, University of Basel, Basel, Switzerland"},{"name":"Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"zoi240867r2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/978-3-662-57295-5","article-title":"Neonatologie [article in 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