{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:56:13Z","timestamp":1791082573685,"version":"4.1.0"},"reference-count":34,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi241021-4\"><jats:title>Importance<\/jats:title><jats:p>Deep brain stimulation (DBS) results in improvements in motor function and quality of life in patients with Parkinson disease (PD), which might impact a patient\u2019s perception of valued personal characteristics. Prior studies investigating whether DBS causes unwanted changes to oneself or one\u2019s personality have methodological limitations that should be addressed.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi241021-5\"><jats:title>Objective<\/jats:title><jats:p>To determine whether DBS is associated with changes in characteristics that patients with PD identify as personally meaningful.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi241021-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This cohort study assessed changes in visual analog scale (VAS) ratings reflecting the extent to which patients with PD manifested individually identified personal characteristics before and 6 and 12 months after DBS at a large academic medical center from February 21, 2018, to December 9, 2021. The VAS findings were tailored to reflect the top 3 individually identified personal characteristics the patient most feared losing. The VASs were scored from 0 to 10, with 0 representing the least and 10 the most extreme manifestation of the trait. Change scores were examined at the individual level. Content analysis was used to code the qualitative data. Qualitative and quantitative analyses were performed from January 12, 2019 (initial qualitative coding), to December 15, 2023.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi241021-7\"><jats:title>Exposure<\/jats:title><jats:p>Deep brain stimulation.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi241021-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>The primary outcome variable was the mean VAS score for the top 3 personal characteristics. The secondary outcome was the incidence of meaningful changes on the patients\u2019 top 3 characteristics at the individual level.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi241021-9\"><jats:title>Results<\/jats:title><jats:p>Fifty-two of 54 dyads of patients with PD and their care partners (96.3%) were recruited from a consecutive series approved for DBS (36 patients [69.2%] were male and 45 care partners [86.5%] were female; mean [SD] age of patients,\u200961.98\u2009[8.55] years). Two patients and 1 care partner were lost to follow-up. Increases in the mean VAS score (indicative of greater manifestation of [ie, positive changes in] specific characteristics) were apparent following DBS for ratings of both the patients (Wald \u03c7<jats:sup>2<\/jats:sup>\u2009=\u200916.104; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001) and care partners (Wald \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20096.746; <jats:italic>P<\/jats:italic>\u2009&amp;amp;lt;\u2009.001) over time. The slopes of the changes for both the patient and care partners were correlated, indicating agreement in observed changes over time. The individual level analyses indicated that scores for most patients and care partners remained the same or increased.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi241021-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>In this cohort study, participants reported greater (more positive) manifestations of individually identified, valued characteristics after DBS. These findings may be relevant to informing decision-making for patients with advanced PD who are considering DBS.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.34255","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T15:02:00Z","timestamp":1726671720000},"page":"e2434255","source":"Crossref","is-referenced-by-count":7,"title":["A Patient-Centered Perspective on Changes in Personal Characteristics After Deep Brain Stimulation"],"prefix":"10.1001","volume":"7","author":[{"given":"Amanda R.","family":"Merner","sequence":"first","affiliation":[{"name":"Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio"},{"name":"Center for Bioethics, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Frazier","sequence":"additional","affiliation":[{"name":"Department of Psychology, John Carroll University, University Heights, Ohio"},{"name":"Department of 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Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Wilt","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences, Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Racine","sequence":"additional","affiliation":[{"name":"Montreal Clinical Research Institute, Montreal, Quebec, Canada"},{"name":"Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Department of Medicine, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Gase","sequence":"additional","affiliation":[{"name":"Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essence","family":"Leslie","sequence":"additional","affiliation":[{"name":"Center for Neurological Restoration, Cleveland 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