{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:08:56Z","timestamp":1782454136652,"version":"3.54.5"},"reference-count":16,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>A diagnosis of bacterial meningitis in childhood can lead to permanent neurological disabilities. Few studies have examined long-term consequences for work ability in adulthood.<\/jats:p><\/jats:sec>Objective<\/jats:title>To compare earnings, work loss, and educational attainment between adults diagnosed with bacterial meningitis in childhood and population comparators.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This nationwide registry-based matched cohort study included individuals in Sweden diagnosed with bacterial meningitis in childhood (aged &amp;lt;18 years) from January 1, 1987, to December 31, 2019, and general population comparators matched 1:9 on age, sex, and place of residence. Follow-up was completed December 31, 2020. Data were analyzed from February 7 to September 12, 2023.<\/jats:p><\/jats:sec>Exposure<\/jats:title>A diagnosis of bacterial meningitis in childhood recorded in the National Patient Register.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Annual taxable earnings (in 2020 US dollars), work loss (sum of sick leave and disability insurance), and educational attainment.<\/jats:p><\/jats:sec>Results<\/jats:title>The cohort included 2534 individuals diagnosed with bacterial meningitis in childhood (mean [SD] age at diagnosis, 4.7 [5.3] years) and 22\u202f806 comparators (13 510 [53.3%] male). Among those with childhood bacterial meningitis, 812 (32.0%) were diagnosed at younger than 1 year and 1351 (53.3%) were male. From 18 to 34 years of age, those with childhood meningitis had lower adjusted earnings relative to comparators and higher adjusted work loss. When pooling observations for individuals 28 years or older, the annual mean reduction in earnings was \u2212$1295 (95% CI, \u2212$2587 to \u2212$4), representing a 4.0% (95% CI, 0%-8.0%) reduction relative to comparators, and the annual increase in work loss was 13.5 (95% CI, 8.6-18.5) days. There was a larger reduction in earnings for those with childhood meningitis relative to comparators with pneumococcal (Streptococcus pneumoniae<\/jats:italic>) vs meningococcal (Neisseria meningitidis<\/jats:italic>) meningitis. For work loss, there was a difference among all 3 major causes of meningitis, with the largest increase for pneumococcal meningitis. Individuals diagnosed at a younger age (below the median) had lower earnings relative to comparators and higher work loss than individuals diagnosed at an older age (above the median). Fewer individuals with childhood meningitis relative to comparators had obtained a high school degree at age 30 years (adjusted odds ratio, 0.68 [95% CI, 0.56-0.81]).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this cohort study of adults diagnosed with bacterial meningitis in childhood, findings suggest that work ability decreases relative to population comparators, with lower earnings and higher work loss, especially among adults diagnosed with pneumococcal meningitis or diagnosed at a young age, with long-lasting costs for the individual patient and society at large.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.45497","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T16:01:27Z","timestamp":1733155287000},"page":"e2445497","source":"Crossref","is-referenced-by-count":7,"title":["Adult Work Ability Following Diagnosis of Bacterial Meningitis in 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