{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:25:41Z","timestamp":1793766341440,"version":"4.6.1"},"reference-count":54,"publisher":"American Medical Association (AMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Health-related quality of life is a critical health outcome and a clinically important patient-reported outcome in clinical trials. Hearing loss is associated with poorer health-related quality-of-life in older adults.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate the 3-year outcomes of hearing intervention vs health education control on health-related quality of life.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This secondary analysis of a randomized clinical trial included participants treated for hearing loss at multiple US centers between 2018 and 2019 with 3-year follow-up completed in 2022. Eligible participants were aged 70 to 84 years, had untreated hearing loss, and were without substantial cognitive impairment. Participants were randomized (1:1) to hearing intervention or health education control and followed every 6 months.<\/jats:p><\/jats:sec>Intervention<\/jats:title>Hearing intervention (provision of hearing aids and related technologies, counseling, education) or health education control (individual sessions covering topics relevant to chronic disease, disability prevention).<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Three-year change in the RAND-36 physical and mental health component scores over 3 years. The 8 individual domains of health-related quality-of-life were additionally assessed. Outcomes measured at baseline and at 6-month, 1-year, 2-year, and 3-year follow-ups. Intervention effect sizes estimated using a 2-level linear mixed effects model under the intention-to-treat principle.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 977 participants were analyzed (mean [SD] age, 76.8 [4.0] years; 523 female [53.5%]; 112 Black [11.5%], 858 White [87.8%]; 521 had a Bachelor\u2019s degree or higher [53.4%]), with 490 in the hearing intervention and 487 in the control group. Over 3 years, hearing intervention (vs health education control) had no significant association with physical (intervention, \u22120.49 [95% CI, \u22123.05 to 2.08]; control, \u22120.92 [95% CI, \u22123.39 to 1.55]; difference, 0.43 [95% CI, \u22120.64 to 1.51]) or mental (intervention, 0.38 [95% CI, \u22121.58 to 2.34]; control, \u22120.09 [95% CI, \u22121.99 to 1.81]; difference, 0.47 [95% CI, \u22120.41 to 1.35]) health-related quality of life.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this secondary analysis of a randomized clinical trial, hearing intervention had no association with physical and mental health-related quality-of-life over 3 years among older adults with hearing loss. Additional intervention strategies may be needed to modify health-related quality among older adults with hearing loss.<\/jats:p><\/jats:sec>Trial Registration<\/jats:title>ClinicalTrials.gov Identifier: NCT03243422<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.46591","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T16:00:53Z","timestamp":1732204853000},"page":"e2446591","source":"Crossref","is-referenced-by-count":11,"title":["A Hearing Intervention and Health-Related Quality of Life in Older Adults"],"prefix":"10.1001","volume":"7","author":[{"given":"Alison R.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"},{"name":"Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel 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