{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:27:41Z","timestamp":1790666861142,"version":"4.1.0"},"reference-count":51,"publisher":"American Medical Association (AMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi241443-4\"><jats:title>Importance<\/jats:title><jats:p>Given the personal and social burdens of opioid use disorder (OUD), understanding time trends in OUD prevalence in large patient populations is key to planning prevention and treatment services.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi241443-5\"><jats:title>Objective<\/jats:title><jats:p>To examine trends in the prevalence of OUD from 2005 to 2022 overall and by age, sex, and race and ethnicity.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi241443-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This serial cross-sectional study included national Veterans Health Administration (VHA) electronic medical record data from the VHA Corporate Data Warehouse. Adult patients (age \u226518 years) with a current OUD diagnosis (using <jats:italic>International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM]<\/jats:italic> and <jats:italic>International Statistical Classification of Diseases, Tenth Revision, Clinical Modification [ICD-10-CM]<\/jats:italic> codes) who received outpatient care at VHA facilities from January 1, 2005, to December 31, 2022, were eligible for inclusion in the analysis.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi241443-7\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>The main outcome was OUD diagnoses. To test for changes in prevalence of OUD over time, multivariable logistic regression models were run that included categorical study year and were adjusted for sex, race and ethnicity, and categorical age.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi241443-8\"><jats:title>Results<\/jats:title><jats:p>The final sample size ranged from 4\u202f332\u202f165 to 5\u202f962\u202f564 per year; most were men (89.3%-95.0%). Overall, the annual percentage of VHA patients diagnosed with OUD almost doubled from 2005 to 2017 (0.60% [95% CI, 0.60%-0.61%] to 1.16% [95% CI, 1.15%-1.17%]; adjusted difference, 0.55 [95% CI, 0.54-0.57] percentage points) and declined thereafter (2022: 0.97% [95% CI, 0.97%-0.98%]; adjusted difference from 2017 to 2022, \u22120.18 [95% CI, \u22120.19 to \u22120.17] percentage points). This trend was similar among men (0.64% [95% CI, 0.63%-0.64%] in 2005 vs 1.22% [95% CI, 1.21%-1.23%] in 2017 vs 1.03% [95% CI, 1.02%-1.04%] in 2022), women (0.34% [95% CI, 0.32%-0.36%] in 2005 vs 0.68% [95% CI, 0.66%-0.69%] in 2017 vs 0.53% [95% CI, 0.52%-0.55%] in 2022), those younger than 35 years (0.62% [95% CI, 0.59%-0.66%] in 2005 vs 2.22% [95% CI, 2.18%-2.26%] in 2017 vs 1.00% [95% CI, 0.97%-1.03%] in 2022), those aged 35 to 64 years (1.21% [95% CI, 1.19%-1.22%] in 2005 vs 1.80% [95% CI, 1.78%-1.82%] in 2017 vs 1.41% [95% CI, 1.39%-1.42%] in 2022), and non-Hispanic White patients (0.44% [95% CI, 0.43%-0.45%] in 2005 vs 1.28% [95% CI, 1.27%-1.29%] in 2017 vs 1.13% [95% CI, 1.11%-1.14%] in 2022). Among VHA patients aged 65 years or older, OUD diagnoses increased from 2005 to 2022 (0.06% [95% CI, 0.06%-0.06%] to 0.61% [95% CI, 0.60%-0.62%]), whereas among Hispanic or Latino and non-Hispanic Black patients, OUD diagnoses decreased from 2005 (0.93% [95% CI, 0.88%-0.97%] and 1.26% [95% CI, 1.23%-1.28%], respectively) to 2022 (0.61% [95% CI, 0.59%-0.63%] and 0.82% [95% CI, 0.80%-0.83%], respectively).<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi241443-9\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>This serial cross-sectional study of national VHA electronic health record data found that the prevalence of OUD diagnoses increased from 2005 to 2017, peaked in 2017, and declined thereafter, a trend primarily attributable to changes among non-Hispanic White patients and those younger than 65 years. Continued public health efforts aimed at recognizing, treating, and preventing OUD are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.51821","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T16:31:14Z","timestamp":1734712274000},"page":"e2451821","source":"Crossref","is-referenced-by-count":14,"title":["Trends in Opioid Use Disorder in the Veterans Health Administration, 2005-2022"],"prefix":"10.1001","volume":"7","author":[{"given":"Lauren R.","family":"Gorfinkel","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Columbia University Irving Medical Center, New York, New York"},{"name":"New York State Psychiatric Institute, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Malte","sequence":"additional","affiliation":[{"name":"Health Services Research and Development, Seattle Center of Innovation for Veteran-Centered and Value-Driven Care, Veterans Affairs (VA) 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