{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:11:32Z","timestamp":1791216692924,"version":"4.1.0"},"reference-count":53,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Disease characteristics of genetically mediated coronary artery disease (CAD) on coronary angiography and the association of genomic risk with outcomes after coronary angiography are not well understood.<\/jats:p><\/jats:sec>Objective<\/jats:title>To assess the angiographic characteristics and risk of post\u2013coronary angiography outcomes of patients with genomic drivers of CAD: familial hypercholesterolemia (FH), high polygenic risk score (PRS), and clonal hematopoiesis of indeterminate potential (CHIP).<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>A retrospective cohort study of 3518 Mass General Brigham Biobank participants with genomic information who underwent coronary angiography was conducted between July 18, 2000, and August 1, 2023.<\/jats:p><\/jats:sec>Exposures<\/jats:title>The presence of a genomic risk factor of CAD, defined as FH variant, high CAD PRS, or CHIP driver variation.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Coronary artery disease presentation (stable or acute), angiographic CAD characteristics (severity and burden), angiographic outcomes (repeat angiogram, revascularization, and in-stent restenosis), and clinical outcomes (heart failure and all-cause mortality).<\/jats:p><\/jats:sec>Results<\/jats:title>Among 3518 participants (2467 [70.1%] male; median age, 64.0 [IQR, 55.0-72.0] years), 1509 (42.9%) had at least 1 genomic driver of CAD (26 FH, 1191 high CAD PRS, and 466 CHIP) that was associated with the presentation of acute coronary syndromes (adjusted odds ratio, 2.67; 95% CI, 2.19-3.26) and with the presence, burden, and severity of angiographic CAD. This association was driven by FH and CAD PRS. One SD of CAD PRS was associated with a 12.51-point higher Gensini score. During 9 years of follow-up, there was an increased risk among FH carriers for a repeat angiogram (adjusted hazard ratio [AHR], 1.70; 95% CI, 1.02-2.83), and revascularization (AHR, 1.97; 95% CI, 1.02-3.80), and among people with high CAD PRS (repeat angiogram: AHR, 1.79; 95% CI, 1.45-2.22; revascularization: AHR, 1.85; 95% CI, 1.37-2.50; and in-stent restenosis: AHR, 3.89; 95% CI, 2.16-7.01). CHIP carriers had no significant increase in angiographic outcomes but were at higher risk of heart failure (AHR, 1.58; 95% CI, 1.04-2.40) and all-cause mortality (AHR, 1.78; 95% CI, 1.47-2.16).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>The findings of this study suggest that germline monogenic and polygenic risk are associated with acute coronary syndromes presentation, severity and burden of atherosclerosis, and risk of repeat angiogram, revascularization, and in-stent restenosis. CHIP variant status is associated with incident heart failure and mortality after coronary angiography.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.55368","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T16:12:48Z","timestamp":1737475968000},"page":"e2455368","source":"Crossref","is-referenced-by-count":8,"title":["Genomic Drivers of Coronary Artery Disease and Risk of Future Outcomes After Coronary Angiography"],"prefix":"10.1001","volume":"8","author":[{"given":"Kelvin","family":"Supriami","sequence":"first","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Urbut","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R.","family":"Tello-Ayala","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"},{"name":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"Unlu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel F.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roukoz","family":"Abou-Karam","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Koyama","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Mesbah","family":"Uddin","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Pomerantsev","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Honigberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna G.","family":"Aragam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finale","family":"Doshi-Velez","sequence":"additional","affiliation":[{"name":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniruddh P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston"},{"name":"Personalized Medicine, Mass General Brigham, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T.","family":"Ellinor","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akl C.","family":"Fahed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"},{"name":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Division of Cardiology, Massachusetts General Hospital, Boston"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"issue":"22","key":"zoi241556r1","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/j.jacc.2020.04.027","article-title":"Limitations of contemporary guidelines for managing patients at high genetic risk of coronary artery disease.","volume":"75","author":"Aragam","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"zoi241556r2","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.1161\/ATVBAHA.120.314856","article-title":"Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease.","volume":"40","author":"Hindy","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"zoi241556r3","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2023.117356","article-title":"Clinical applications of polygenic risk score for coronary artery disease through the life course.","volume":"386","author":"Fahed","year":"2023","journal-title":"Atherosclerosis"},{"issue":"9","key":"zoi241556r4","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1161\/CIRCRESAHA.120.315928","article-title":"Polygenic scores to assess atherosclerotic cardiovascular disease risk: clinical perspectives and basic implications.","volume":"126","author":"Aragam","year":"2020","journal-title":"Circ Res"},{"issue":"6","key":"zoi241556r5","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nrg.2016.160","article-title":"Genetics of coronary artery disease: discovery, biology and clinical translation.","volume":"18","author":"Khera","year":"2017","journal-title":"Nat Rev Genet"},{"issue":"3","key":"zoi241556r6","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.2687","article-title":"Association of the interaction between familial hypercholesterolemia variants and adherence to a healthy lifestyle with risk of coronary artery disease.","volume":"5","author":"Fahed","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"8","key":"zoi241556r7","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1001\/jamacardio.2021.1301","article-title":"Limited-variant screening vs comprehensive genetic testing for familial hypercholesterolemia diagnosis.","volume":"6","author":"Sturm","year":"2021","journal-title":"JAMA Cardiol"},{"issue":"1","key":"zoi241556r8","doi-asserted-by":"publisher","first-page":"8861","DOI":"10.1038\/s41598-018-27248-w","article-title":"Familial hypercholesterolemia in very young myocardial infarction.","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"issue":"6","key":"zoi241556r9","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.jacc.2018.05.044","article-title":"Clinical genetic testing for familial hypercholesterolemia: JACC Scientific Expert Panel.","volume":"72","author":"Sturm","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"zoi241556r10","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/s41588-018-0183-z","article-title":"Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.","volume":"50","author":"Khera","year":"2018","journal-title":"Nat Genet"},{"issue":"7","key":"zoi241556r11","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1038\/s41591-023-02429-x","article-title":"A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.","volume":"29","author":"Patel","year":"2023","journal-title":"Nat Med"},{"issue":"5","key":"zoi241556r12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41569-021-00638-w","article-title":"Clinical utility of polygenic risk scores for coronary artery disease.","volume":"19","author":"Klarin","year":"2022","journal-title":"Nat Rev Cardiol"},{"issue":"2","key":"zoi241556r13","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1056\/NEJMoa1701719","article-title":"Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease.","volume":"377","author":"Jaiswal","year":"2017","journal-title":"N Engl J Med"},{"issue":"3","key":"zoi241556r14","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1001\/jamacardio.2023.5095","article-title":"Somatic and germline variants and coronary heart disease in a Chinese population.","volume":"9","author":"Zhao","year":"2024","journal-title":"JAMA Cardiol"},{"issue":"17","key":"zoi241556r15","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1056\/NEJMoa2200963","article-title":"CT or invasive coronary angiography in stable chest pain.","volume":"386","author":"Maurovich-Horvat","year":"2022","journal-title":"N Engl J Med"},{"issue":"6","key":"zoi241556r16","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1002\/ccd.22656","article-title":"Coronary angiography is a better predictor of mortality than noninvasive testing in patients evaluated for renal transplantation.","volume":"76","author":"Enkiri","year":"2010","journal-title":"Catheter Cardiovasc Interv"},{"issue":"36","key":"zoi241556r17","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.1093\/eurheartj\/ehad380","article-title":"Genetic, sociodemographic, lifestyle, and clinical risk factors of recurrent coronary artery disease events: a population-based cohort study.","volume":"44","author":"Cho","year":"2023","journal-title":"Eur Heart J"},{"issue":"8","key":"zoi241556r18","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.3390\/jpm12081323","article-title":"The evolution of a large biobank at Mass General Brigham.","volume":"12","author":"Boutin","year":"2022","journal-title":"J Pers Med"},{"issue":"1","key":"zoi241556r19","doi-asserted-by":"publisher","first-page":"3635","DOI":"10.1038\/s41467-020-17374-3","article-title":"Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions.","volume":"11","author":"Fahed","year":"2020","journal-title":"Nat Commun"},{"issue":"4","key":"zoi241556r20","doi-asserted-by":"publisher","first-page":"e203959","DOI":"10.1001\/jamanetworkopen.2020.3959","article-title":"Association of rare pathogenic DNA variants for familial hypercholesterolemia, hereditary breast and ovarian cancer syndrome, and lynch syndrome with disease risk in adults according to family history.","volume":"3","author":"Patel","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"11","key":"zoi241556r21","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.911","article-title":"Pragmatic approach to applying polygenic risk scores to diverse populations.","volume":"3","author":"Patel","year":"2023","journal-title":"Curr Protoc"},{"issue":"20","key":"zoi241556r22","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1016\/j.jacc.2023.03.401","article-title":"Clonal hematopoiesis of indeterminate potential predicts adverse outcomes in patients with atherosclerotic cardiovascular disease.","volume":"81","author":"Gumuser","year":"2023","journal-title":"J Am Coll Cardiol"},{"issue":"7831","key":"zoi241556r23","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s41586-020-2819-2","article-title":"Inherited causes of clonal haematopoiesis in 97,691 whole genomes.","volume":"586","author":"Bick","year":"2020","journal-title":"Nature"},{"issue":"18","key":"zoi241556r24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI168597","article-title":"Genetic modification of inflammation- and clonal hematopoiesis\u2013associated cardiovascular risk.","volume":"133","author":"Yu","year":"2023","journal-title":"J Clin Invest"},{"issue":"7913","key":"zoi241556r25","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41586-022-04785-z","article-title":"The longitudinal dynamics and natural history of clonal haematopoiesis.","volume":"606","author":"Fabre","year":"2022","journal-title":"Nature"},{"issue":"6","key":"zoi241556r26","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.ccell.2023.04.006","article-title":"Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population.","volume":"41","author":"van Zeventer","year":"2023","journal-title":"Cancer Cell"},{"issue":"1","key":"zoi241556r27","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12979-022-00278-9","article-title":"Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics.","volume":"19","author":"Uddin","year":"2022","journal-title":"Immun Ageing"},{"key":"zoi241556r28","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.atherosclerosis.2019.05.012","article-title":"A guide for Gensini score calculation.","volume":"287","author":"Rampidis","year":"2019","journal-title":"Atherosclerosis"},{"issue":"1","key":"zoi241556r29","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41746-022-00590-0","article-title":"Cohort design and natural language processing to reduce bias in electronic health records research.","volume":"5","author":"Khurshid","year":"2022","journal-title":"NPJ Digit Med"},{"issue":"7","key":"zoi241556r31","doi-asserted-by":"publisher","first-page":"121","DOI":"10.21037\/atm.2018.02.12","article-title":"Time-varying covariates and coefficients in Cox regression models.","volume":"6","author":"Zhang","year":"2018","journal-title":"Ann Transl Med"},{"issue":"10","key":"zoi241556r33","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/sim.9681","article-title":"A comparison of different methods to adjust survival curves for confounders.","volume":"42","author":"Denz","year":"2023","journal-title":"Stat Med"},{"issue":"1","key":"zoi241556r34","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12944-019-1074-8","article-title":"Comparison of long-term outcomes of young patients after a coronary event associated with familial hypercholesterolemia.","volume":"18","author":"Wang","year":"2019","journal-title":"Lipids Health Dis"},{"issue":"1","key":"zoi241556r35","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12944-021-01467-z","article-title":"Coronary lesion complexity in patients with heterozygous familial hypercholesterolemia hospitalized for acute myocardial infarction: data from the RICO survey.","volume":"20","author":"Yao","year":"2021","journal-title":"Lipids Health Dis"},{"issue":"1","key":"zoi241556r36","doi-asserted-by":"publisher","first-page":"6535","DOI":"10.1038\/s41467-023-41985-1","article-title":"Clinical utility of polygenic scores for cardiometabolic disease in Arabs.","volume":"14","author":"Shim","year":"2023","journal-title":"Nat Commun"},{"issue":"3","key":"zoi241556r37","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014795","article-title":"Genetic risk of coronary artery disease, features of atherosclerosis, and coronary plaque burden.","volume":"9","author":"Christiansen","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"7","key":"zoi241556r38","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.033413","article-title":"Polygenic scores and preclinical cardiovascular disease in individuals with HIV: insights from the REPRIEVE trial.","volume":"13","author":"Zou","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"zoi241556r39","doi-asserted-by":"publisher","DOI":"10.1016\/j.plabm.2021.e00202","article-title":"Familial hypercholesterolemia and vulnerability of coronary plaque in patients with coronary artery disease.","volume":"24","author":"Katamine","year":"2021","journal-title":"Pract Lab Med"},{"issue":"5","key":"zoi241556r40","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.ajhg.2023.03.013","article-title":"Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures.","volume":"110","author":"\u00d6rd","year":"2023","journal-title":"Am J Hum Genet"},{"issue":"10","key":"zoi241556r42","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/s41569-021-00542-3","article-title":"Plaque erosion and acute coronary syndromes: phenotype, molecular characteristics and future directions.","volume":"18","author":"Fahed","year":"2021","journal-title":"Nat Rev Cardiol"},{"issue":"2","key":"zoi241556r43","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jacc.2014.01.015","article-title":"Clinical utility of intravascular imaging and physiology in coronary artery disease.","volume":"64","author":"Mintz","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"zoi241556r44","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.121.003440","article-title":"Coronary artery disease polygenic risk score identifies patients at higher risk for recurrent cardiovascular events in the CANTOS trial.","volume":"14","author":"Xu","year":"2021","journal-title":"Circ Genom Precis Med"},{"issue":"1","key":"zoi241556r45","doi-asserted-by":"publisher","first-page":"2922","DOI":"10.1038\/s41467-022-30675-z","article-title":"The potential of polygenic scores to improve cost and efficiency of clinical trials.","volume":"13","author":"Fahed","year":"2022","journal-title":"Nat Commun"},{"issue":"11","key":"zoi241556r46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.118.002352","article-title":"Genomic risk stratification predicts all-cause mortality after cardiac catheterization.","volume":"11","author":"Levin","year":"2018","journal-title":"Circ Genom Precis Med"},{"issue":"1","key":"zoi241556r47","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.53244","article-title":"Clonal hematopoiesis and incident heart failure with preserved ejection fraction.","volume":"7","author":"Schuermans","year":"2024","journal-title":"JAMA Netw Open"},{"issue":"26","key":"zoi241556r48","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes.","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N Engl J Med"},{"issue":"1","key":"zoi241556r49","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jacc.2021.04.085","article-title":"Supplemental association of clonal hematopoiesis with incident heart failure.","volume":"78","author":"Yu","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"zoi241556r50","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1001\/jamainternmed.2017.7821","article-title":"Comparison of physician visual assessment with quantitative coronary angiography in assessment of stenosis severity in China.","volume":"178","author":"Zhang","year":"2018","journal-title":"JAMA Intern Med"},{"issue":"1","key":"zoi241556r51","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/s41746-023-00880-1","article-title":"CathAI: fully automated coronary angiography interpretation and stenosis estimation.","volume":"6","author":"Avram","year":"2023","journal-title":"NPJ Digit Med"},{"issue":"3","key":"zoi241556r52","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/clc.4960150305","article-title":"Accuracy and reproducibility of visual coronary stenosis estimates using information from multiple observers.","volume":"15","author":"Kussmaul","year":"1992","journal-title":"Clin Cardiol"},{"issue":"10","key":"zoi241556r53","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1136\/heartjnl-2020-318289","article-title":"The new role of diagnostic angiography in coronary physiological assessment.","volume":"107","author":"Ghobrial","year":"2021","journal-title":"Heart"},{"key":"zoi241556r30","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-21706-2","volume-title":"Modern Applied Statistics with S","author":"Venables","year":"2002","edition":"4th ed"},{"key":"zoi241556r32","volume-title":"Modeling Survival Data: Extending the Cox Model","author":"Therneau","year":"2013"},{"key":"zoi241556r41","doi-asserted-by":"crossref","unstructured":"Heimlich? JB, Raddatz? MA, Wells? J, . Clonal hematopoiesis of indeterminate potential status is associated with left main artery stenosis.? medRxiv. 2023:2023.02. doi:10.1101\/2023.02.10.23285708","DOI":"10.1101\/2023.02.10.23285708"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2829417\/supriami_2025_oi_241556_1736782470.38049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T16:12:53Z","timestamp":1737475973000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2829417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,2]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.55368","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]}}}