{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:44:57Z","timestamp":1782362697910,"version":"3.54.5"},"reference-count":6,"publisher":"American Medical Association (AMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:p>This cross-sectional study reports on the study design characteristics of clinical trials for novel psychiatric drugs approved by the US Food and Drug Administration.<\/jats:p>","DOI":"10.1001\/jamanetworkopen.2024.56588","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T16:33:05Z","timestamp":1737995585000},"page":"e2456588","source":"Crossref","is-referenced-by-count":4,"title":["Characteristics of Trials Preceding FDA Approval of Novel Psychiatric Drugs"],"prefix":"10.1001","volume":"8","author":[{"given":"Rosa Y.","family":"Ahn-Horst","sequence":"first","affiliation":[{"name":"Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Psychiatry, Massachusetts General Hospital, Boston"},{"name":"Department of Psychiatry, McLean Hospital, Belmont, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick H.","family":"Turner","sequence":"additional","affiliation":[{"name":"Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Psychiatry, Oregon Health & Science University, Portland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron S.","family":"Kesselheim","sequence":"additional","affiliation":[{"name":"Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"issue":"2","key":"zld240286r1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S2215-0366(21)00395-3","article-title":"Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.","volume":"9","author":"GBD 2019 Mental Disorders Collaborators","year":"2022","journal-title":"Lancet Psychiatry"},{"issue":"2","key":"zld240286r2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/wps.21079","article-title":"Biomarkers for clinical use in psychiatry: where are we and will we ever get there?","volume":"22","author":"Yatham","year":"2023","journal-title":"World Psychiatry"},{"key":"zld240286r3","first-page":"5","article-title":"Psychiatric drug development: diagnosing a crisis.","volume":"2013","author":"Hyman","year":"2013","journal-title":"Cerebrum"},{"issue":"1","key":"zld240286r4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41386-023-01690-5","article-title":"Finding new and better treatments for psychiatric disorders.","volume":"49","author":"Paul","year":"2024","journal-title":"Neuropsychopharmacology"},{"issue":"155","key":"zld240286r6","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003142","article-title":"Revolution stalled.","volume":"4","author":"Hyman","year":"2012","journal-title":"Sci Transl Med"},{"key":"zld240286r5","unstructured":"FDA. Drugs@FDA: FDA-approved drugs. Accessed August 23, 2024. https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/index.cfm"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2829552\/ahnhorst_2025_ld_240286_1737127982.58505.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T16:33:20Z","timestamp":1737995600000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2829552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,2]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.56588","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,27]]}}}