{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:24:16Z","timestamp":1791897856372,"version":"4.3.4"},"reference-count":40,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Clinical observations of immediate improvement in fraction of inspired oxygen (FiO2<\/jats:sub>) in a proportion of cases is often cited as the rationale for using inhaled nitric oxide (iNO) in the management of acute pulmonary hypertension among very preterm neonates (gestational age, &amp;lt;32 weeks). However, the clinical effectiveness of such a response pattern remains underinvestigated.<\/jats:p><\/jats:sec>Objective<\/jats:title>To identify factors associated with predischarge mortality among very preterm neonates receiving iNO for acute pulmonary hypertension, with specific a priori emphasis on iNO responsiveness.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This prospective observational cohort study was conducted from January 1, 2018, to December 31, 2022, at 12 Canadian tertiary neonatal intensive care units. Consecutive very preterm neonates who received iNO for a diagnosis of acute pulmonary hypertension and pretreatment FiO2<\/jats:sub> of 0.50 or more were included. Neonates with congenital anomalies or those who were treated for chronic pulmonary hypertension with iNO were excluded. Early acute pulmonary hypertension (\u226472 hours of age) and late acute pulmonary hypertension (&amp;gt;72 hours of age) cohorts were analyzed separately. Statistical analysis was performed from January 2023 to January 2024.<\/jats:p><\/jats:sec>Exposure<\/jats:title>Treatment with iNO for acute pulmonary hypertension.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The study cohorts were divided for comparison based on the primary outcome of predischarge mortality. Logistic regression analyses were used with predefined variables, including iNO responsiveness, to identify factors associated with mortality. A positive response to iNO was defined as a pre-iNO minus 4-hour post-iNO FiO2<\/jats:sub> of 0.20 or more.<\/jats:p><\/jats:sec>Results<\/jats:title>The early acute pulmonary hypertension group (mean [SD] birth gestational age, 26.3 [2.4] weeks; median treatment age, 1 day [IQR, 1-2 days]; 147 boys [56%]) included 262 neonates; 179 (68%) had a pre-iNO FiO2<\/jats:sub> of 1.0. The late acute pulmonary hypertension group (mean [SD] birth gestational age, 24.9 [1.7] weeks; median treatment age, 13 days [IQR, 9-20 days]; 72 boys [66%]) included 109 neonates; 51 (47%) had a pre-iNO FiO2<\/jats:sub> of 1.0. Neonates with early acute pulmonary hypertension more frequently had a positive iNO response (71% [186 of 262] vs 41% [45 of 109]) and lower mortality (34% [90 of 262] vs 49% [53 of 109]) than those with late acute pulmonary hypertension. Accounting for pretreatment illness factors, greater reduction in FiO2<\/jats:sub> with iNO remained associated with lower mortality for neonates with early acute pulmonary hypertension (adjusted odds ratio per FiO2<\/jats:sub> reduction of 0.10, 0.74 [95% CI, 0.65-0.84]). For those with late acute pulmonary hypertension, however, only pretreatment illness severity (lower pre-iNO FiO2<\/jats:sub> and higher pre-iNO pH), and not positive response to iNO (adjusted odds ratio, 0.47 [95% CI, 0.17-1.30]), was associated with mortality.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this cohort study of very preterm neonates with acute pulmonary hypertension treated with iNO, responsiveness to iNO was associated with improved outcomes during the first 72 hours of age. The prognostic role of iNO response in acute pulmonary hypertension presenting after 72 hours of age remains unclear. Future studies should investigate the distinct pathophysiological mechanisms associated with late acute pulmonary hypertension in this population.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.58843","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T16:01:19Z","timestamp":1739203279000},"page":"e2458843","source":"Crossref","is-referenced-by-count":11,"title":["Response to Inhaled Nitric Oxide and Mortality Among Very Preterm Neonates With Pulmonary Hypertension"],"prefix":"10.1001","volume":"8","author":[{"given":"Michelle","family":"Baczynski","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dany","family":"Weisz","sequence":"additional","affiliation":[{"name":"Department of Newborn & Developmental Paediatrics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Fevrier","sequence":"additional","affiliation":[{"name":"Department of Newborn & Developmental Paediatrics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Castaldo","sequence":"additional","affiliation":[{"name":"Division of Neonatology, BC Children\u2019s & Women\u2019s Health Centre, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amuchou","family":"Soraisham","sequence":"additional","affiliation":[{"name":"Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Hyderi","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Royal Alexandra Hospital, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rula","family":"Agarushi","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Royal Alexandra Hospital, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soume","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Division of Neonatology, London Health Sciences Centre, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjini","family":"Lalitha","sequence":"additional","affiliation":[{"name":"Division of Neonatology, London Health Sciences Centre, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amneet","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Hamilton Health Sciences Centre, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzafar Gani","family":"Abdul Wahab","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Hamilton Health Sciences Centre, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Altit","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Montreal Children\u2019s Hospital, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"H\u00e9bert","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Centre Hospitalier Universitaire de Qu\u00e9bec, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Louis","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Health Sciences Centre Winnipeg, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Saint Boniface Hospital, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souvik","family":"Mitra","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorva","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Kharrat","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Ting","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Stollery Children\u2019s Hospital, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakesh S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amish","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Canadian Neonatal Network Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Fajardo","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Wong","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Kajetanowicz","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Piedboeuf","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Drolet","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Bertelle","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Masse","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anie","family":"Lapointe","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Ethier","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Barrington","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Lemyre","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"Makary","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Aziz","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Abou Mehrem","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Mukerji","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Seshia","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Louis","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong-Soon","family":"Lee","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehier","family":"Afifi","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo-Anna","family":"Hudson","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Bizgu","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Nouraeyen","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiza","family":"Khurshid","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Coughlin","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"St-Hilaire","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Beltempo","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Zeid","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakeshkumar","family":"Shah","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Harabor","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Toye","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Ting","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Stavel","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lannae","family":"Strueby","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Nunes","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wissam","family":"Alburaki","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Yi","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Ruth","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Ng","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Sherlock","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Costa","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thevanisha","family":"Pillay","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajit","family":"Augustine","sequence":"additional","affiliation":[{"name":"for the Canadian Neonatal Network Investigators"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"issue":"1","key":"zoi241645r1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000399.pub3","article-title":"Nitric oxide for respiratory failure in infants born at or near term.","volume":"1","author":"Barrington","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"21","key":"zoi241645r2","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1161\/CIR.0000000000000329","article-title":"Pediatric pulmonary hypertension: guidelines from the American Heart Association and American Thoracic Society.","volume":"132","author":"Abman","year":"2015","journal-title":"Circulation"},{"issue":"1","key":"zoi241645r3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000509.pub5","article-title":"Inhaled nitric oxide for respiratory failure in preterm infants.","volume":"1","author":"Barrington","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"zoi241645r4","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1542\/peds.2010-2725","article-title":"Inhaled nitric oxide in preterm infants: an individual-patient data meta-analysis of randomized trials.","volume":"128","author":"Askie","year":"2011","journal-title":"Pediatrics"},{"issue":"4","key":"zoi241645r5","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1542\/peds.2014-3290","article-title":"Off-label use of inhaled nitric oxide after release of NIH consensus statement.","volume":"135","author":"Ellsworth","year":"2015","journal-title":"Pediatrics"},{"issue":"7","key":"zoi241645r6","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1055\/s-0036-1571329","article-title":"Trends and variations in the use of inhaled nitric oxide in preterm infants in Canadian neonatal intensive care units.","volume":"33","author":"Soraisham","year":"2016","journal-title":"Am J Perinatol"},{"key":"zoi241645r7","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-01252-x","author":"Nelin","year":"2022","journal-title":"J Perinatol"},{"issue":"5","key":"zoi241645r8","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.clinthera.2019.03.008","article-title":"An analysis of time to improvement in oxygenation in Japanese preterm and late preterm or term neonates with hypoxic respiratory failure and pulmonary hypertension.","volume":"41","author":"Rhine","year":"2019","journal-title":"Clin Ther"},{"key":"zoi241645r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2023.105841","article-title":"Association between immediate oxygenation response and survival in preterm infants receiving rescue inhaled nitric oxide therapy for hypoxemia from pulmonary hypertension: a systematic review and meta-analysis.","volume":"184","author":"Baczynski","year":"2023","journal-title":"Early Hum Dev"},{"issue":"10","key":"zoi241645r10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"4","author":"von Elm","year":"2007","journal-title":"PLoS Med"},{"issue":"1","key":"zoi241645r12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12887-019-1492-9","article-title":"Respiratory severity score as a predictive factor for severe bronchopulmonary dysplasia or death in extremely preterm infants.","volume":"19","author":"Jung","year":"2019","journal-title":"BMC Pediatr"},{"issue":"13","key":"zoi241645r13","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1055\/a-2267-4719","article-title":"Respiratory severity score and neurodevelopmental outcomes at age 3 years in extremely preterm infants.","volume":"41","author":"Tamai","year":"2024","journal-title":"Am J Perinatol"},{"issue":"7","key":"zoi241645r14","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","article-title":"Bronchopulmonary dysplasia.","volume":"163","author":"Jobe","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"zoi241645r15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis: therapeutic decisions based upon clinical staging.","volume":"187","author":"Bell","year":"1978","journal-title":"Ann Surg"},{"issue":"4","key":"zoi241645r16","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm.","volume":"92","author":"Papile","year":"1978","journal-title":"J Pediatr"},{"issue":"3","key":"zoi241645r17","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1542\/peds.91.3.617","article-title":"Score for neonatal acute physiology: a physiologic severity index for neonatal intensive care.","volume":"91","author":"Richardson","year":"1993","journal-title":"Pediatrics"},{"issue":"2","key":"zoi241645r18","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1542\/peds.2010-3507","article-title":"NIH Consensus Development Conference statement: inhaled nitric-oxide therapy for premature infants.","volume":"127","author":"Cole","year":"2011","journal-title":"Pediatrics"},{"issue":"9","key":"zoi241645r19","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.healun.2019.06.022","article-title":"2019 Updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: the European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT.","volume":"38","author":"Hansmann","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"zoi241645r20","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0258-9","author":"Manja","year":"2019","journal-title":"J Perinatol"},{"issue":"4","key":"zoi241645r21","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.hrtlng.2014.04.014","article-title":"Use of inhaled nitric oxide in preterm infants: a regional survey of practices.","volume":"43","author":"Sasi","year":"2014","journal-title":"Heart Lung"},{"issue":"3","key":"zoi241645r22","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/apa.17075","article-title":"Treating very preterm European infants with inhaled nitric oxide increased in-hospital mortality but did not affect neurodevelopment at 5?years of age.","volume":"113","author":"Siljehav","year":"2024","journal-title":"Acta Paediatr"},{"issue":"7","key":"zoi241645r23","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.0761","article-title":"Association of early inhaled nitric oxide with the survival of preterm neonates with pulmonary hypoplasia.","volume":"172","author":"Ellsworth","year":"2018","journal-title":"JAMA Pediatr"},{"key":"zoi241645r24","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0131-x","author":"Baczynski","year":"2018","journal-title":"J Perinatol"},{"issue":"6","key":"zoi241645r25","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1515\/jpm-2017-0040","article-title":"Efficacy of inhaled nitric oxide in neonates with hypoxic respiratory failure and pulmonary hypertension: the Japanese experience.","volume":"46","author":"Suzuki","year":"2018","journal-title":"J Perinat Med"},{"key":"zoi241645r26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.earlhumdev.2018.09.004","article-title":"The efficacy of inhaled nitric oxide treatment in premature infants with acute pulmonary hypertension.","volume":"127","author":"Rallis","year":"2018","journal-title":"Early Hum Dev"},{"issue":"6","key":"zoi241645r27","doi-asserted-by":"publisher","first-page":"F508","DOI":"10.1136\/archdischild-2016-312409","article-title":"Short-term and long-term outcomes of preterm neonates with acute severe pulmonary hypertension following rescue treatment with inhaled nitric oxide.","volume":"102","author":"Baczynski","year":"2017","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"zoi241645r28","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-022-01582-4","author":"Boly","year":"2023","journal-title":"J Perinatol"},{"issue":"4","key":"zoi241645r29","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1159\/000501800","article-title":"Nitric oxide in pulmonary hypoplasia: results from the European iNO Registry.","volume":"116","author":"Kettle","year":"2019","journal-title":"Neonatology"},{"issue":"6","key":"zoi241645r30","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1515\/JPM.2004.126","article-title":"Plasma endothelin-1 and clinical manifestations of neonatal sepsis.","volume":"32","author":"Figueras-Aloy","year":"2004","journal-title":"J Perinat Med"},{"key":"zoi241645r31","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2022.105657","article-title":"Validity of the vasoactive-inotropic score in preterm neonates receiving cardioactive therapies.","volume":"173","author":"Kharrat","year":"2022","journal-title":"Early Hum Dev"},{"key":"zoi241645r32","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.1904872","author":"Doucette","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"key":"zoi241645r33","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0130-y","author":"Papadhima","year":"2018","journal-title":"J Perinatol"},{"issue":"2","key":"zoi241645r34","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.echo.2023.11.016","article-title":"Guidelines and recommendations for targeted neonatal echocardiography and cardiac point-of-care ultrasound in the neonatal intensive care unit: an update from the American Society of Echocardiography.","volume":"37","author":"McNamara","year":"2024","journal-title":"J Am Soc Echocardiogr"},{"issue":"4","key":"zoi241645r35","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.siny.2015.03.001","article-title":"Persistent pulmonary hypertension of the newborn: advances in diagnosis and treatment.","volume":"20","author":"Jain","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"issue":"4","key":"zoi241645r36","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1152\/physrev.00032.2009","article-title":"Regulation of the pulmonary circulation in the fetus and newborn.","volume":"90","author":"Gao","year":"2010","journal-title":"Physiol Rev"},{"key":"zoi241645r37","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.43","author":"Lakshminrusimha","year":"2016","journal-title":"J Perinatol"},{"issue":"8","key":"zoi241645r38","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S2213-2600(17)30214-X","article-title":"The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity.","volume":"5","author":"De Luca","year":"2017","journal-title":"Lancet Respir Med"},{"key":"zoi241645r39","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3389\/fped.2019.00340","article-title":"Vascular endothelium in neonatal sepsis: basic mechanisms and translational opportunities.","volume":"7","author":"Pietrasanta","year":"2019","journal-title":"Front Pediatr"},{"issue":"2","key":"zoi241645r40","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1203\/pdr.0b013e31802d77db","article-title":"Intestinal microcirculatory dysfunction during the development of experimental necrotizing enterocolitis.","volume":"61","author":"Ito","year":"2007","journal-title":"Pediatr Res"},{"key":"zoi241645r11","unstructured":"The Canadian Neonatal Network. Updated June 24, 2022. Accessed December 22, 2024. http:\/\/www.canadianneonatalnetwork.org\/portal\/CNNHome.aspx"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2830084\/baczynski_2025_oi_241645_1738355079.68972.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T16:01:23Z","timestamp":1739203283000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2830084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,3]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.58843","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]}}}