{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:57:21Z","timestamp":1792713441597,"version":"4.5.0"},"reference-count":53,"publisher":"American Medical Association (AMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n The neurobiology of avoidant\/restrictive food intake disorder (ARFID) is poorly understood.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate whether individuals with ARFID exhibit disruptions in fear, appetite, and disgust brain regions compared with healthy control (HC) participants when shown images of food and objects.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n In this case-control study conducted from July 2016 to January 2021, children, adolescents, and young adults completed structured interviews and a validated functional magnetic resonance imaging (fMRI) food cue paradigm. The study was conducted at a single academic medical center. Data analysis was conducted from April 2023 to August 2024.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n Presence vs absence of ARFID and its phenotypes (ARFID-fear, ARFID\u2013lack of interest in eating, ARFID\u2013sensory sensitivity); pictures of food vs objects during fMRI food cue paradigm.<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Blood oxygenation level\u2013dependent activation in regions of interest (ROIs; amygdala, hypothalamus, insula, anterior cingulate cortex [ACC]) and the whole brain.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Participants were 110 children, adolescents, and young adults with full or subthreshold ARFID (75 participants; mean [SD] age, 16.2 [3.8] years; 41 [55%] female) and age-matched HC participants (35 participants; mean [SD] age, 17.3 [4.0] years; 27 [69%] female) recruited for studies of the neurobiology of ARFID and restrictive eating disorders. Participants with ARFID demonstrated greater activation than HC participants of the ACC (mean difference, 0.48 [95% CI, 0.19 to 0.77];\n P<\/jats:italic>\n \u2009=\u2009.009), sensory association cortex (mean difference on left side, 0.54 [95% CI, 0.29 to 0.79];\n P<\/jats:italic>\n \u2009=\u2009.005; right side, 0.52 [95% CI, 0.28 to 0.76];\n P<\/jats:italic>\n \u2009=\u2009.02), and supplementary motor cortex (mean difference, 0.81 [95% CI, 0.47 to 1.15];\n P<\/jats:italic>\n \u2009=\u2009.04). The ARFID-fear group showed greater amygdala activation vs HC (mean difference, 0.49 [95% CI, 0.16 to 0.82];\n P<\/jats:italic>\n \u2009=\u2009.04), and greater lack of interest was associated with lower hypothalamus activation in the ARFID\u2013lack of interest group (\n r<\/jats:italic>\n \u2009=\u2009\u22120.38 [95% CI, \u22120.69 to \u22120.11];\n P<\/jats:italic>\n \u2009=\u2009.03). The ARFID\u2013sensory sensitivity group did not show greater insula activation vs HC but showed greater activation of the ACC (mean difference, 0.48 [95% CI, 0.22 to 0.74];\n P<\/jats:italic>\n \u2009=\u2009.005) and somatosensory cortex (mean difference on left side, 0.60 [95% CI, 0.33-0.87];\n P<\/jats:italic>\n \u2009=\u2009.001; right side, 0.54 [95% CI, 0.29 to 0.80];\n P<\/jats:italic>\n \u2009=\u2009.03).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n Results indicate generalized hyperactivation of ACC, sensory association cortex, and supplementary motor cortex in response to visual food stimuli in children, adolescents, and young adults\t with ARFID, suggesting a novel neurobiological circuit associated with this disorder. Activation appears consistent with ARFID phenotypic rationales for food avoidance, with hyperactivation of fear regions in ARFID-fear and hypoactivation of appetite regions with increasing ARFID\u2013lack of interest severity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.60101","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T11:06:50Z","timestamp":1739876810000},"page":"e2460101","source":"Crossref","is-referenced-by-count":19,"title":["Neural Response to Food Cues in Avoidant\/Restrictive Food Intake Disorder"],"prefix":"10.1001","volume":"8","author":[{"given":"Jennifer J.","family":"Thomas","sequence":"first","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Holsen","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Division of Women\u2019s Health, Department of Medicine, and Department of Psychiatry, Brigham and Women\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avery L.","family":"Van De Water","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"},{"name":"Division of Women\u2019s Health, Department of Medicine, and Department of Psychiatry, Brigham and Women\u2019s Hospital, Boston, Massachusetts"},{"name":"Neuroendocrine Unit, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra R.","family":"Becker","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Breithaupt","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Burton-Murray","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Center for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Asanza","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"},{"name":"Neuroendocrine Unit, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Gydus","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"},{"name":"Neuroendocrine Unit, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian P.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey M.","family":"Stern","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Freizinger","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Psychiatry and Behavioral Sciences, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia A.","family":"Shrier","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Division of Adolescent\/Young Adult Medicine, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elana M.","family":"Bern","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Deckersbach","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Division of Neurotherapeutics, Massachusetts General Hospital, Charlestown"},{"name":"University of Applied Sciences, DIPLOMA Hochschule, Bad Sooden-Allendorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusmita","family":"Misra","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Pediatrics, University of Virginia, Charlottesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamryn T.","family":"Eddy","sequence":"additional","affiliation":[{"name":"Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Micali","sequence":"additional","affiliation":[{"name":"Eating Disorders Research Unit, Mental Health Center Ballerup, Mental Health Services of the Capital Region of Denmark, Ballerup, Denmark"},{"name":"Great Ormond Street Institute of Child Health, University College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Lawson","sequence":"additional","affiliation":[{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative, Boston, Massachusetts"},{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Neuroendocrine Unit, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"issue":"2","key":"zoi241679r1","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/erv.2964","article-title":"What do we know about the epidemiology of avoidant\/restrictive food intake disorder in children and adolescents? a systematic review of the literature.","volume":"31","author":"Sanchez-Cerezo","year":"2023","journal-title":"Eur Eat Disord Rev"},{"issue":"1","key":"zoi241679r2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/eat.23440","article-title":"Estimated prevalence of eating disorders in Singapore.","volume":"54","author":"Chua","year":"2021","journal-title":"Int J Eat Disord"},{"key":"zoi241679r3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s40337-017-0149-z","article-title":"Burden and health-related quality of life of eating disorders, including Avoidant\/Restrictive Food Intake Disorder (ARFID), in the Australian population.","volume":"5","author":"Hay","year":"2017","journal-title":"J Eat Disord"},{"key":"zoi241679r5","doi-asserted-by":"publisher","author":"Kambanis","journal-title":"J Am Acad Child Adolesc Psychiatry","DOI":"10.1016\/j.jaac.2024.04.010"},{"key":"zoi241679r6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/1741-7015-11-126","article-title":"Toward the future of psychiatric diagnosis: the seven pillars of RDoC.","volume":"11","author":"Cuthbert","year":"2013","journal-title":"BMC Med"},{"issue":"8","key":"zoi241679r7","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s11920-017-0795-5","article-title":"Avoidant\/restrictive food intake disorder: a three-dimensional model of neurobiology with implications for etiology and treatment.","volume":"19","author":"Thomas","year":"2017","journal-title":"Curr Psychiatry Rep"},{"issue":"2","key":"zoi241679r8","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/eat.22814","article-title":"Building evidence for the use of descriptive subtypes in youth with avoidant restrictive food intake disorder.","volume":"51","author":"Norris","year":"2018","journal-title":"Int J Eat Disord"},{"issue":"4","key":"zoi241679r9","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/erv.2670","article-title":"Exploring the cooccurrence of behavioural phenotypes for avoidant\/restrictive food intake disorder in a partial hospitalization sample.","volume":"27","author":"Reilly","year":"2019","journal-title":"Eur Eat Disord Rev"},{"issue":"4","key":"zoi241679r10","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/eat.23016","article-title":"Further support for diagnostically meaningful ARFID symptom presentations in an adolescent medicine partial hospitalization program.","volume":"52","author":"Zickgraf","year":"2019","journal-title":"Int J Eat Disord"},{"issue":"6","key":"zoi241679r11","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1097\/MPG.0000000000003774","article-title":"Assessment of patients with ARFID presenting to multi-disciplinary tertiary care program.","volume":"76","author":"Richmond","year":"2023","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"12","key":"zoi241679r13","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/S0006-3223(98)00275-3","article-title":"Emotion, motivation, and anxiety: brain mechanisms and psychophysiology.","volume":"44","author":"Lang","year":"1998","journal-title":"Biol Psychiatry"},{"key":"zoi241679r14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","article-title":"Emotion circuits in the brain.","volume":"23","author":"LeDoux","year":"2000","journal-title":"Annu Rev Neurosci"},{"issue":"11","key":"zoi241679r15","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1176\/appi.ajp.2016.16030353","article-title":"Using neuroscience to help understand fear and anxiety: a two-system framework.","volume":"173","author":"LeDoux","year":"2016","journal-title":"Am J Psychiatry"},{"issue":"5","key":"zoi241679r16","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/pcn.12055","article-title":"Meta-analysis of functional brain imaging in specific phobia.","volume":"67","author":"Ipser","year":"2013","journal-title":"Psychiatry Clin Neurosci"},{"issue":"8","key":"zoi241679r17","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1038\/s41386-020-0661-8","article-title":"Neural correlates of conceptual-level fear generalization in posttraumatic stress disorder.","volume":"45","author":"Morey","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"zoi241679r18","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.tem.2017.02.006","article-title":"Neural circuit mechanisms underlying emotional regulation of homeostatic feeding.","volume":"28","author":"Sweeney","year":"2017","journal-title":"Trends Endocrinol Metab"},{"issue":"6","key":"zoi241679r19","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1159\/000503147","article-title":"Hypothalamic structural and functional imbalances in anorexia nervosa.","volume":"110","author":"Florent","year":"2020","journal-title":"Neuroendocrinology"},{"issue":"3","key":"zoi241679r20","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0896-6273(03)00679-2","article-title":"Both of us disgusted in my insula: the common neural basis of seeing and feeling disgust.","volume":"40","author":"Wicker","year":"2003","journal-title":"Neuron"},{"key":"zoi241679r21","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.neubiorev.2017.05.008","article-title":"Core, social and moral disgust are bounded: a review on behavioral and neural bases of repugnance in clinical disorders.","volume":"80","author":"Vicario","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"zoi241679r22","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1002\/hbm.23848","article-title":"Mapping the sequence of brain events in response to disgusting food.","volume":"39","author":"Pujol","year":"2018","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"zoi241679r23","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s11682-017-9726-7","article-title":"Conflict-related dorsomedial frontal cortex activation during healthy food decisions is associated with increased cravings for high-fat foods.","volume":"12","author":"Smith","year":"2018","journal-title":"Brain Imaging Behav"},{"key":"zoi241679r24","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.920170","article-title":"Brain responses to food choices and decisions depend on individual hedonic profiles and eating habits in healthy young women.","volume":"9","author":"Coquery","year":"2022","journal-title":"Front Nutr"},{"issue":"5","key":"zoi241679r25","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1007\/s11682-021-00455-2","article-title":"The processing of visual food cues during bitter aftertaste perception in females with high vs. low disgust propensity: an fMRI study.","volume":"15","author":"Schienle","year":"2021","journal-title":"Brain Imaging Behav"},{"issue":"3","key":"zoi241679r26","doi-asserted-by":"publisher","first-page":"490","DOI":"10.4103\/1673-5374.153701","article-title":"Compensatory recombination phenomena of neurological functions in central dysphagia patients.","volume":"10","author":"Yuan","year":"2015","journal-title":"Neural Regen Res"},{"issue":"5","key":"zoi241679r27","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1080\/15374416.2021.1894944","article-title":"Neurobiology of avoidant\/restrictive food intake disorder in youth with overweight\/obesity versus healthy weight.","volume":"51","author":"Kerem","year":"2022","journal-title":"J Clin Child Adolesc Psychol"},{"issue":"5","key":"zoi241679r28","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1503\/jpn.110156","article-title":"Food motivation circuitry hypoactivation related to hedonic and nonhedonic aspects of hunger and satiety in women with active anorexia nervosa and weight-restored women with anorexia nervosa.","volume":"37","author":"Holsen","year":"2012","journal-title":"J Psychiatry Neurosci"},{"issue":"2","key":"zoi241679r29","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.pscychresns.2014.04.015","article-title":"Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa.","volume":"223","author":"Holsen","year":"2014","journal-title":"Psychiatry Res"},{"issue":"9596","key":"zoi241679r30","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"issue":"5","key":"zoi241679r31","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/eat.22388","article-title":"The eating disorder assessment for DSM-5 (EDA-5): development and validation of a structured interview for feeding and eating disorders.","volume":"48","author":"Sysko","year":"2015","journal-title":"Int J Eat Disord"},{"issue":"4","key":"zoi241679r33","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/eat.22958","article-title":"Development of the Pica, ARFID, and rumination disorder interview, a multi-informant, semi-structured interview of feeding disorders across the lifespan: a pilot study for ages 10-22.","volume":"52","author":"Bryant-Waugh","year":"2019","journal-title":"Int J Eat Disord"},{"issue":"5","key":"zoi241679r35","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1080\/15374416.2022.2034634","article-title":"Eighteen-month course and outcome of adolescent restrictive eating disorders: persistence, crossover, and recovery.","volume":"51","author":"Breithaupt","year":"2022","journal-title":"J Clin Child Adolesc Psychol"},{"issue":"4","key":"zoi241679r36","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/14640746708400109","article-title":"The binomial distribution of right, mixed and left handedness.","volume":"19","author":"Annett","year":"1967","journal-title":"Q J Exp Psychol"},{"key":"zoi241679r37","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105243","article-title":"Ghrelin and PYY in low-weight females with avoidant\/restrictive food intake disorder compared to anorexia nervosa and healthy controls.","volume":"129","author":"Becker","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"zoi241679r38","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.21m14111","author":"Burton Murray","year":"2022","journal-title":"J Clin Psychiatry"},{"key":"zoi241679r39","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2024.107063","article-title":"Trajectory of ghrelin and PYY around a test meal in males and females with avoidant\/restrictive food intake disorder versus healthy controls.","volume":"167","author":"Rozzell-Voss","year":"2024","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"zoi241679r40","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jbct.2020.10.004","article-title":"Cognitive-behavioral therapy for adults with avoidant\/restrictive food intake disorder.","volume":"31","author":"Thomas","year":"2021","journal-title":"J Behav Cogn Ther"},{"issue":"10","key":"zoi241679r41","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1002\/eat.23355","article-title":"Cognitive-behavioral therapy for avoidant\/restrictive food intake disorder: feasibility, acceptability, and proof-of-concept for children and adolescents.","volume":"53","author":"Thomas","year":"2020","journal-title":"Int J Eat Disord"},{"issue":"11","key":"zoi241679r42","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1002\/eat.23792","article-title":"The factor structure and validity of a diagnostic interview for avoidant\/restrictive food intake disorder in a sample of children, adolescents, and young adults.","volume":"55","author":"Cooper-Vince","year":"2022","journal-title":"Int J Eat Disord"},{"issue":"1","key":"zoi241679r43","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/s41398-023-02494-3","article-title":"Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls.","volume":"13","author":"Eddy","year":"2023","journal-title":"Transl Psychiatry"},{"key":"zoi241679r47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116189","article-title":"Automated anatomical labelling atlas 3.","volume":"206","author":"Rolls","year":"2020","journal-title":"Neuroimage"},{"issue":"8","key":"zoi241679r48","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.2174\/1570159X15666171017111532","article-title":"Neural network alterations across eating disorders: a narrative review of fMRI studies.","volume":"16","author":"Steward","year":"2018","journal-title":"Curr Neuropharmacol"},{"issue":"6","key":"zoi241679r49","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1017\/S0033291721004049","article-title":"Evidence that a novel transdiagnostic eating disorder treatment reduces reward region response to the thin beauty ideal and high-calorie binge foods.","volume":"53","author":"Stice","year":"2023","journal-title":"Psychol Med"},{"issue":"8","key":"zoi241679r50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002939","article-title":"A common anterior insula representation of disgust observation, experience and imagination shows divergent functional connectivity pathways.","volume":"3","author":"Jabbi","year":"2008","journal-title":"PLoS One"},{"issue":"8","key":"zoi241679r51","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1523\/JNEUROSCI.21-08-02793.2001","article-title":"Predictability modulates human brain response to reward.","volume":"21","author":"Berns","year":"2001","journal-title":"J Neurosci"},{"key":"zoi241679r52","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40337-018-0217-z","article-title":"What can food-image tasks teach us about anorexia nervosa? a systematic review.","volume":"6","author":"Lloyd","year":"2018","journal-title":"J Eat Disord"},{"issue":"3","key":"zoi241679r53","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.neuroimage.2005.04.043","article-title":"Neural mechanisms underlying food motivation in children and adolescents.","volume":"27","author":"Holsen","year":"2005","journal-title":"Neuroimage"},{"key":"zoi241679r4","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013","edition":"5th ed"},{"key":"zoi241679r12","volume-title":"Cognitive-Behavioral Therapy for Avoidant\/Restrictive Food Intake Disorder","author":"Thomas","year":"2019"},{"key":"zoi241679r32","author":"Kaufman","year":"2013"},{"key":"zoi241679r34","author":"Fairburn","year":"2008"},{"key":"zoi241679r44","unstructured":"Wellcome Trust Center for Neuroimaging. SPM12. Updated January 13, 2020. Accessed January 16, 2025. https:\/\/www.fil.ion.ucl.ac.uk\/spm\/software\/spm12\/"},{"key":"zoi241679r45","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing. Accessed January 16, 2025. https:\/\/www.R-project.org\/"},{"key":"zoi241679r46","unstructured":"NITRC. Artifact Detection Tools (ART): Tool\/Resource Info. Accessed January 16, 2025. https:\/\/www.nitrc.org\/projects\/artifact_detect\/"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2830346\/thomas_2025_oi_241679_1738950502.47301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T11:06:54Z","timestamp":1739876814000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2830346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,3]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.60101","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,18]]}}}