{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:01:38Z","timestamp":1791378098973,"version":"4.3.2"},"reference-count":46,"publisher":"American Medical Association (AMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Several studies have reported a higher incidence of neurodevelopmental delays and cognitive deficits in patients with single-suture craniosynostosis; however, there are few studies examining the associations of repair type with cognitive outcomes.<\/jats:p><\/jats:sec>Objective<\/jats:title>To measure differences in neuropsychological outcomes between school-age children who were treated for sagittal craniosynostosis and unaffected controls and explore differences in cognitive function among children with sagittal craniosynostosis who were previously treated with either endoscopic strip craniectomy or open calvarial vault surgery.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study was performed between 2018 and 2022. Eligible participants included patients aged 5 to 17 years who had previously been seen as infants or toddlers (&amp;lt;3 years) at 1 of 3 surgical centers for craniosynostosis repair with either endoscopic surgery or open calvarial vault surgery. A separate cohort of unaffected controls were included for comparison. Data analysis was conducted from November 2023 to February 2024.<\/jats:p><\/jats:sec>Exposures<\/jats:title>Open calvarial vault surgery or endoscopic repair for single-suture craniosynostosis.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcome was the Differential Ability Scales-II (DAS-II) General Conceptual Ability (GCA) score, an index for overall intellectual ability. Secondary outcomes included DAS-II subscale scores (Verbal Ability, Nonverbal Reasoning, Spatial Ability, Working Memory, and Processing Speed), and Patient-Reported Outcomes Measurement Information System (PROMIS) cognitive function scores.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 81 patients with sagittal craniosynostosis (59 male [73%]; 22 female [27%]) and 141 controls (81 male [57%]; 60 female [43%]) were included. Of the 81 participants with sagittal craniosynostosis, 46 underwent endoscopic repair and 35 underwent open repair. Median (range) age at time of follow-up assessment was 7.7 (5.0-14.8) years for children with sagittal craniosynostosis and median age at assessment was 8.5 (7.7-10.5) years for controls. After controlling for age at assessment, sex, and socioeconomic status, there was no statistically significant or clinically meaningful difference in GCA scores between children who underwent endoscopic repair (adjusted mean score, 100; 95% CI, 96-104) and open repair (adjusted mean score, 103; 95% CI, 98-108) (P<\/jats:italic>\u2009&amp;gt;\u2009.99). We found no significant difference in PROMIS scores between repair types (median [range] for endoscopic repair 54 [31-68] vs median [range] for open repair 50 [32-63]; P<\/jats:italic>\u2009=\u2009.14). When comparing the treatment groups with the unaffected controls, differences in subscale scores for GCA and working memory were observed but were within normal range.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this cohort study, there were no statistically or clinically significant differences in cognitive outcomes among school-age children by and type of surgical procedure used to repair nonsyndromic sagittal craniosynostosis. These findings suggest primary care clinicians should be educated about different options for craniosynostosis surgery to ensure early referral of these patients so that all treatment options remain viable.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2024.8762","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T15:33:39Z","timestamp":1714404819000},"page":"e248762","source":"Crossref","is-referenced-by-count":26,"title":["Cognitive Outcomes of Children With Sagittal Craniosynostosis Treated With Either Endoscopic or Open Calvarial Vault Surgery"],"prefix":"10.1001","volume":"7","author":[{"given":"Suresh N.","family":"Magge","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Michigan, Ann Arbor"},{"name":"Division of Neurosurgery, Children\u2019s Hospital of Orange County Neuroscience Institute, Children\u2019s Hospital of Orange County, Orange, California"},{"name":"Division of Neurosurgery, 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