{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:51:52Z","timestamp":1793328712011,"version":"4.5.0"},"reference-count":65,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Physical activity (PA) is a nonpharmacological intervention for dementia prevention. The association between PA and Alzheimer disease (AD) plasma biomarkers remains underexplored.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate the associations among PA; plasma biomarkers, including \u03b2-amyloid 42\/40 (A\u03b242\/40), phosphorylated-tau217 (ptau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL); and cognition.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This cross-sectional study included participants with and without cognitive impairment recruited from multiple memory clinics in South Korea between May 2019 and May 2022. Data were analyzed from June to December 2024.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n PA was assessed as metabolic equivalent task minutes per week using the International Physical Activity Questionnaire and categorized into quartiles from the lowest (Q1) to the highest (Q4).<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Plasma A\u03b242\/40, ptau217, GFAP, and NfL were measured. Cognition was assessed using the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating-Sum of Boxes (CDR-SB).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 1144 participants (mean [SD] age 70.9 [8.7] years; 744 [65.0%] female), the highest PA quartile showed significantly lower ptau217 (estimate [SE], \u22120.14 [0.06];\n P<\/jats:italic>\n \u2009=\u2009.01) and NfL (estimate [SE], \u22120.12 [0.05];\n P<\/jats:italic>\n \u2009=\u2009.01) compared with the lowest quartile. Higher PA quartiles were associated with higher MMSE scores (estimate [SE]: Q2, 0.93 [0.31];\n P<\/jats:italic>\n \u2009=\u2009.003; Q3, 0.82 [0.32];\n P<\/jats:italic>\n \u2009=\u2009.009; Q4, 0.94 [0.32];\n P<\/jats:italic>\n \u2009=\u2009.004) and lower CDR-SB scores (estimate [SE]: Q2, \u20130.33 [0.16];\n P<\/jats:italic>\n \u2009=\u2009.04; Q3, \u20130.37 [0.16];\n P<\/jats:italic>\n \u2009=\u2009.02; Q4, \u20130.55 [0.16];\n P<\/jats:italic>\n \u2009=\u2009.001) after adjusting for age, sex, education years, and \u03b2-amyloid uptake. In subgroup analyses according to age and cognitive status, the associations of PA and plasma biomarkers with cognition were more pronounced in the older (age \u226565 years) and cognitively impaired groups compared with the younger and cognitively unimpaired groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n These findings suggest that PA may help delay cognitive decline by modulating neurodegeneration and AD-specific tau pathologies. However, the cross-sectional design limits causal inference, and longitudinal studies are needed to confirm and clarify these associations.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.0096","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T11:01:00Z","timestamp":1741172460000},"page":"e250096","source":"Crossref","is-referenced-by-count":30,"title":["Physical Activity, Alzheimer Plasma Biomarkers, and Cognition"],"prefix":"10.1001","volume":"8","author":[{"given":"Seung Ae","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul, South Korea"},{"name":"Seoul National University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daeun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongki","family":"Ham","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea"},{"name":"Alzheimer\u2019s Disease Convergence Research Center, Samsung Medical Center, Seoul, South Korea"},{"name":"Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, South Korea"},{"name":"Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeshin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kangwon National University College of Medicine, Chuncheon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea"},{"name":"Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea"},{"name":"Alzheimer\u2019s Disease Convergence Research Center, Samsung Medical Center, Seoul, South Korea"},{"name":"Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea"},{"name":"Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk L.","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea"},{"name":"Happymid Clinic, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden"},{"name":"Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom"},{"name":"UK Dementia Research Institute, University College London, London, United Kingdom"},{"name":"Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden"},{"name":"Paris Brain Institute, ICM, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Sorbonne University, Paris, France"},{"name":"Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea"},{"name":"Alzheimer\u2019s Disease Convergence Research Center, Samsung Medical Center, Seoul, South Korea"},{"name":"Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea"},{"name":"Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, South Korea"},{"name":"Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyemin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University Hospital, Seoul, South Korea"},{"name":"Seoul National University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Precision Medicine Platform for Mild Cognitive Impairment Based on Multi-omics, Imaging, Evidence-Based R&BD (PREMIER) Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Seo","sequence":"additional","affiliation":[{"name":"for the Precision Medicine Platform for Mild Cognitive Impairment Based on 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