{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:27:50Z","timestamp":1789093670110,"version":"build-2803163510"},"reference-count":32,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"<jats:sec id=\"ab-zoi250012-4\"><jats:title>Importance<\/jats:title><jats:p>Improving mental health of young people is a major societal challenge, particularly among the high numbers of young people living in deprived urban areas.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250012-5\"><jats:title>Objective<\/jats:title><jats:p>To identify factors associated with depression and anxiety among young people in deprived urban areas in South America.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250012-6\"><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>This case-control study recruited adolescents (age 15-16 years) and young adults (age 20-24 years) from education and community settings in deprived areas in Bogot\u00e1, Colombia; Buenos Aires, Argentina; and Lima, Peru, between April 2021 and November 2022. Participants who met threshold criteria for self-reported depression or anxiety. Community controls who did not meet the criteria were identified.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250012-7\"><jats:title>Exposures<\/jats:title><jats:p>Sociodemographic characteristics, stressful life events before and during the past year, substance use, social capital, sports and arts activities, social media engagement.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250012-8\"><jats:title>Main Outcomes and Measures<\/jats:title><jats:p>Depression, assessed using the 8-item Patient Health Questionnaire (range, 0-24, with higher scores indicating greater symptom severity), and anxiety, assessed using the 7-item Generalized Anxiety Disorder questionnaire (range, 0-21, with higher scores indicating greater symptom severity), were defined by threshold scores higher than 9. Various factors were compared between groups with and without anxiety and depression in multivariable logistic regression, testing for interactions by age group.<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250012-9\"><jats:title>Results<\/jats:title><jats:p>Of 2402 analyzed participants, 1560 (64.9%) were female, 1080 (45.0%) were adolescents, and 1322 (55.0%) were young adults; 1437 (59.8%) met the criteria for depression and\/or anxiety, and 965 (40.2%) were controls. In a multivariable model, female gender (OR, 1.99 [95% CI, 1.65-2.40), more than 2 stressful life events in the previous year (OR, 1.67 [95% CI, 1.40-2.01]), more than 7 stressful life events before the previous year (OR, 1.52 [95% CI, 1.27-1.81), lifetime consumption of sedatives (OR, 2.26 [95% CI, 1.65-3.14]), participating in arts activities in the past 30 days (OR, 1.22 [95% CI, 1.01-1.48]), and stronger engagement with social media (OR, 1.59 [95% CI, 1.34-1.89]) were independently associated with increased odds of depression and anxiety, while sports activities were associated with reduced odds (OR, 0.80 [95% CI, 0.67-0.96]). The odds of having depression and\/or anxiety symptoms associated with lifetime use of sedatives were higher among adolescents (OR, 6.54 [95% CI, 3.33-14.27]) than among young adults (OR, 2.54 [95% CI, 1.79-3.66]) (<jats:italic>P<\/jats:italic>\u2009=\u2009.01 for interaction).<\/jats:p><\/jats:sec><jats:sec id=\"ab-zoi250012-10\"><jats:title>Conclusions and Relevance<\/jats:title><jats:p>In this case-control study, female gender, stressful life events, substance use, arts activities, and social media engagement were associated with greater odds of depression and anxiety, while sport activities were associated with lesser odds. The findings suggest that policies for improving mental health in deprived urban neighborhoods in South America and related research should consider similar factors associated with mental distress in adolescents and young adults.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.0122","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T16:01:23Z","timestamp":1741190483000},"page":"e250122","source":"Crossref","is-referenced-by-count":21,"title":["Mental Distress Among Youths in Low-Income Urban Areas in South America"],"prefix":"10.1001","volume":"8","author":[{"given":"Carlos","family":"G\u00f3mez-Restrepo","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Mental Health, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"},{"name":"Department of Clinical Epidemiology and Biostatistics, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"},{"name":"Hospital Universitario San Ignacio, Bogot\u00e1, 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