{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:09:35Z","timestamp":1786975775137,"version":"build-2736575974"},"reference-count":41,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Cardiovascular health (CVH), defined by the American Heart Association as Life\u2019s Simple 7 to promote a healthy lifestyle and manage vascular risk factors, has been associated with a low risk of Alzheimer disease and less vascular dementia. However, the association between CVH and biomarkers of neurodegeneration remains less understood.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate the association of CVH with serum biomarkers of neurodegeneration, including neurofilament light chain (NfL) and total tau (t-tau).<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This cohort study was conducted within the biracial, population-based Chicago Health and Aging Project (CHAP) of adults aged 65 years or older between 1993 and 2012. Participants who had measured serum NfL and t-tau levels and data on all components of the CVH score were included. The statistical analysis was conducted from April 10 to September 26, 2024.<\/jats:p>\n <\/jats:sec>\n \n Exposure<\/jats:title>\n The CVH score includes 7 components: a healthy diet; regular exercise; normal body mass index; nonsmoking status; and the absence of dyslipidemia, diabetes, and hypertension. The scores were divided into 3 groups from lowest to highest CVH (0-6 points, 7-9 points, and 10-14 points).<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The main outcome was the association of CVH score with serum biomarkers of NfL and t-tau as measured using linear regression and mixed-effects models.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 1018 CHAP participants were included in the analysis (mean [SD] age, 73.1 [6.1] years; 625 female [61.4%]; 610 Black or African American [59.9%] and 408 White [40.1%]). Participants with a high CVH score (ie, 10-14 points) were predominantly White (151 [64.3%]) and had a higher education (mean [SD], 13.6 [3.7] years). Compared with participants with low CVH scores (ie, 0-6 points), those with CVH scores of 10 to 14 points had significantly lower serum levels of NfL (relative difference, \u221218.9%; \u03b2 = \u22120.091; SE, 0.025). A higher CVH score was associated with a slower annual increase in NfL levels as participants aged (relative difference in rate, \u22121.7%; \u03b2 = \u22120.008; SE, 0.004). Cardiovascular health was not associated with serum levels of t-tau.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n These findings suggest that promoting CVH in older adults may help alleviate the burden of neurodegenerative diseases, particularly among Black adults, who are known to experience a higher prevalence of cardiovascular disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.0527","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:10:33Z","timestamp":1741691433000},"page":"e250527","source":"Crossref","is-referenced-by-count":12,"title":["Cardiovascular Health and Biomarkers of Neurodegenerative Disease in Older Adults"],"prefix":"10.1001","volume":"8","author":[{"given":"Anisa","family":"Dhana","sequence":"first","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois"},{"name":"Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"DeCarli","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, Davis, Sacramento"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klodian","family":"Dhana","sequence":"additional","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois"},{"name":"Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaja","family":"Desai","sequence":"additional","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois"},{"name":"Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted K. S.","family":"Ng","sequence":"additional","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois"},{"name":"Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis A.","family":"Evans","sequence":"additional","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois"},{"name":"Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar B.","family":"Rajan","sequence":"additional","affiliation":[{"name":"Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois"},{"name":"Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois"},{"name":"Department of Neurology, University of California, Davis, 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