{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:57:02Z","timestamp":1791665822055,"version":"4.3.4"},"reference-count":39,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Despite growing criticism of alcohol consumption due to its overall health risks, it remains unknown how changes in alcohol consumption, particularly cessation, affect lipid profiles outside of intense interventions.<\/jats:p><\/jats:sec>Objective<\/jats:title>To clarify the association of alcohol initiation and cessation with subsequent changes in low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C).<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study included individuals undergoing annual checkups at a center for preventive medicine in Tokyo, Japan, from October 2012 to October 2022. Individuals treated with lipid-lowering medications were excluded. Data were analyzed from May to December 2024.<\/jats:p><\/jats:sec>Exposures<\/jats:title>Alcohol initiation (vs remaining abstainer) and cessation (vs continuing same alcohol intake) between 2 consecutive visits. One standard drink was equivalent to 10 g of pure ethanol.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Change in LDL-C and HDL-C levels between 2 consecutive visits.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the 328\u202f676 visits from 57\u202f691 individuals (mean [SD] age, 46.8 [12.5] years; 30\u202f576 female [53.0%]), the cohort for evaluating alcohol cessation comprised 49\u202f898 visits among 25\u202f144 participants (mean [SD] age, 49 [12.1] years; 12\u202f334 female [49.1%]; mean [SD] LDL-C, 114.7 [28.4] mg\/dL; mean [SD] HDL-C, 65.5 [16.4] mg\/dL). Alcohol cessation was associated with changes in LDL-C of 1.10 mg\/dL (95% CI, 0.76 to 1.45 mg\/dL) among those discontinuing habits of fewer than 1.5 drinks\/d, 3.71 mg\/dL (95% CI, 2.71 to 4.71 mg\/dL) for 1.5 to 3.0 drinks\/d, and 6.53 mg\/dL (95% CI, 5.14 to 7.91 mg\/dL) for 3.0 or more drinks\/d. Cessation was associated with a change in HDL-C of \u22121.25 mg\/dL (95% CI, \u22121.41 to \u22121.09 mg\/dL) among those discontinuing habits of fewer than 1.5 drinks\/d, \u22123.35 mg\/dL (\u22124.41 to \u22122.29 mg\/dL) for 1.5 to 3.0 drinks\/d, and \u22125.65 mg\/dL (95% CI, \u22126.28 to \u22125.01 mg\/dL) for 3.0 or more drinks\/d. The cohort for evaluating alcohol initiation (107\u202f880 visits; 29\u202f042 participants) showed inverse dose-response associations.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this cohort study of Japanese annual health checkup participants, alcohol initiation was associated with modest cholesterol improvement, whereas cessation was associated with less favorable changes. After alcohol reduction, lipid profile changes should be carefully monitored to optimize cardiovascular disease risk management at both individual and population levels.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.0583","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T15:01:03Z","timestamp":1741791663000},"page":"e250583","source":"Crossref","is-referenced-by-count":34,"title":["Lipid Profiles After Changes in Alcohol Consumption Among Adults Undergoing Annual Checkups"],"prefix":"10.1001","volume":"8","author":[{"given":"Takahiro","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, St Luke\u2019s International Hospital, Tokyo, Japan"},{"name":"Department of Public Health, Institute of Science Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Fukui","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Massachusetts"},{"name":"Immuno-Rheumatology Center, St Luke\u2019s International Hospital, Tokyo, Japan"},{"name":"Department of Emergency and General Medicine, Kyorin University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Shinozaki","sequence":"additional","affiliation":[{"name":"Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, St Luke\u2019s International Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Graduate School of Nursing Science, St Luke\u2019s International University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiro","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, St Luke\u2019s International Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, St Luke\u2019s International Hospital, Tokyo, Japan"},{"name":"Tokyo Foundation for Policy Research, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"issue":"10152","key":"zoi250049r1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0140-6736(18)31310-2","article-title":"Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.","volume":"392","author":"GBD 2016 Alcohol Collaborators","year":"2018","journal-title":"Lancet"},{"key":"zoi250049r2","doi-asserted-by":"crossref","first-page":"j909","DOI":"10.1136\/bmj.j909","article-title":"Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records.","volume":"356","author":"Bell","year":"2017","journal-title":"BMJ"},{"issue":"11","key":"zoi250049r3","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jacc.2007.04.089","article-title":"Alcohol and cardiovascular health: the razor-sharp double-edged sword.","volume":"50","author":"O\u2019Keefe","year":"2007","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"zoi250049r4","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-043985","article-title":"Are there non-linear relationships between alcohol consumption and long-term health? 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