{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:37:07Z","timestamp":1781332627017,"version":"3.54.1"},"reference-count":43,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Three-year pelvic recurrence rate in women with low-risk cervical carcinoma was not inferior following simple hysterectomy (SH) vs modified radical hysterectomy (MRH) or radical hysterectomy (RH) in the Simple Hysterectomy and Pelvic Node Assessment randomized clinical trial, but the survival analysis of the trial was underpowered.<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate long-term survival in low-risk cervical carcinoma following SH vs MRH or RH.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cohort study included women undergoing SH, MRH or RH in US Commission on Cancer\u2013accredited facilities participating in the National Cancer Database who received a diagnosis between January 2010 and December 2017 of International Federation of Gynecology and Obstetrics 2009 stage IA2 or IB1 squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma of the cervix (\u22642 cm) and clinically negative lymph nodes.<\/jats:p><\/jats:sec>Exposure<\/jats:title>SH, MRH, or RH following diagnosis of stage IA2 or IB1 squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma of the cervix.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>Survival was the primary end point, evaluated with and without propensity score balancing. Survival rates, survival distributions, adjusted hazard ratio (aHR) of death, and restricted mean survival times (RMST) were analyzed as of September 2024. Two multivariable models were fitted. Model 1 included the hysterectomy type and 9 baseline factors (age, comorbidity score, race and ethnicity, insurance status, treatment facility, stage, histologic subtype, tumor grade, and surgical approach). Model 2 included the model 1 variables plus 4 additional clinical factors (surgical margin, LVSI, pathologic LN metastasis, and adjuvant treatment).<\/jats:p><\/jats:sec>Results<\/jats:title>This cohort study evaluated 2636 women (mean [SD] age, 45.4 [11.4] years; median [IQR] follow-up, 85 [64-110] months), including 982 with SH, 300 with MRH, 927 with traditional RH, and 427 with unspecified MRH or RH. Survival was similar following SH vs MRH or RH (7 year survival rate, 93.9%; 95% CI, 91.9%-95.4% vs 95.3%; 95% CI, 94.0%-96.3%%; P<\/jats:italic>\u2009=\u2009.07) and SH vs MRH vs RH (7 year survival rate, 93.9%; 95% CI, 91.9%-95.4% vs 94.2%; 95% CI, 90.1%-96.7% vs 95.4%; 95% CI, 93.6%-96.6%; P<\/jats:italic>\u2009=\u2009.15). Risk of death following either SH vs MRH or RH, SH vs RH, or MRH vs RH remained similar after adjusting for baseline covariates alone or baseline covariates plus clinical factors. Survival remained similar within subsets by age, comorbidity score, race and ethnicity, facility type, stage, histologic subtype, tumor grade, surgical approach, and year of diagnosis. Adjusted survival remained similar in patients with SH vs MRH or RH after propensity score balancing for baseline covariates (aHR, 1.19; 95% CI, 0.86-1.65; P<\/jats:italic>\u2009=\u2009.31) with similar 3-year (98.3%; 95% CI, 97.2%-99.0% vs 97.6%; 95% CI, 96.6%-98.2%), 5-year (95.9%; 95% CI, 94.3%-97.1% vs 96.5%; 95% CI, 95.5%-97.3%), 7-year (94.5%; 95% CI, 92.5%-95.9% vs 95.1%; 95% CI, 93.7%-96.1%), and 10-year (89.8%; 95% CI, 86.3%-92.5% vs 91.7%; 95% CI, 89.4%-93.4%) survival rates. Sensitivity analysis for patients who received a diagnosis between 2010 and 2013 documented similar 10-year RMST following SH vs MRH or RH, SH vs RH, SH vs MRH, and MRH vs RH.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this cohort study, long-term survival was similar following SH vs MRH or RH, supporting the use of SH in select patients with low-risk early-stage cervical carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.10717","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T15:00:39Z","timestamp":1747321239000},"page":"e2510717","source":"Crossref","is-referenced-by-count":7,"title":["Long-Term Survival in Patients With Low-Risk Cervical Cancer After Simple, Modified, or Radical Hysterectomy"],"prefix":"10.1001","volume":"8","author":[{"given":"Christopher M.","family":"Tarney","sequence":"first","affiliation":[{"name":"Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqiao","family":"Tian","sequence":"additional","affiliation":[{"name":"Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland"},{"name":"The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M.","family":"Randall","sequence":"additional","affiliation":[{"name":"Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Mid-Atlantic Gynecologic Oncology and Pelvic Surgery Associates, Inc, Inova Shar Cancer Institute, Falls Church, Virginia"},{"name":"Women\u2019s Health Integrated Research Center, Inova Women\u2019s Service Line, Inova Health System, Falls Church, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Ahmed","family":"Hussain","sequence":"additional","affiliation":[{"name":"Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouya","family":"Javadian","sequence":"additional","affiliation":[{"name":"Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Cronin","sequence":"additional","affiliation":[{"name":"Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Drayer","sequence":"additional","affiliation":[{"name":"Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Chan","sequence":"additional","affiliation":[{"name":"Palo Alto Medical Foundation, California Pacific Medical Center, Sutter Health, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Kapp","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad A.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Section, Women\u2019s Services, The Ochsner Cancer Institute, Ochsner Health, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Charles A.","family":"Leath","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, University of Alabama at Birmingham, O\u2019Neal Comprehensive Cancer Center, Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris M.","family":"Benbrook","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Division, Stephenson Cancer Center, Oklahoma University Health Sciences Center, Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina R.","family":"Washington","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Division, Stephenson Cancer Center, Oklahoma University Health Sciences Center, Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen N.","family":"Moore","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Division, Stephenson Cancer Center, Oklahoma University Health Sciences Center, Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas W.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland"},{"name":"The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Conrads","sequence":"additional","affiliation":[{"name":"Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland"},{"name":"Women\u2019s Health Integrated Research Center, Inova Women\u2019s Service Line, Inova Health System, Falls Church, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil T.","family":"Phippen","sequence":"additional","affiliation":[{"name":"Advent Health Medical Group, Gynecologic Oncology at Porter, Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Larry","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland"},{"name":"Women\u2019s Health Integrated Research Center, Inova Women\u2019s Service Line, Inova Health System, Falls Church, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Darcy","sequence":"additional","affiliation":[{"name":"Gynecologic Cancer Center of Excellence, Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Maryland"},{"name":"Murtha Cancer Center Research Program, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland"},{"name":"The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"issue":"3","key":"zoi250374r1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"zoi250374r2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.2530","article-title":"Trends in human papillomavirus-associated cancers, demographic characteristics, and vaccinations in the US, 2001-2017.","volume":"5","author":"Liao","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"10167","key":"zoi250374r5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0140-6736(18)32470-X","article-title":"Cervical cancer.","volume":"393","author":"Cohen","year":"2019","journal-title":"Lancet"},{"issue":"4","key":"zoi250374r6","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1002\/cncr.2820710407","article-title":"Radical hysterectomy for invasive cervical cancer. A 25-year prospective experience with the Miami technique.","volume":"71","author":"Averette","year":"1993","journal-title":"Cancer"},{"issue":"6","key":"zoi250374r7","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S1470-2045(20)30081-4","article-title":"Quality of life in patients with cervical cancer after open versus minimally invasive radical hysterectomy (LACC): a secondary outcome of a multicentre, randomised, open-label, phase 3, non-inferiority trial.","volume":"21","author":"Frumovitz","year":"2020","journal-title":"Lancet Oncol"},{"issue":"3","key":"zoi250374r8","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.ygyno.2005.11.007","article-title":"Surgical morbidity associated with radical trachelectomy and radical hysterectomy.","volume":"101","author":"Alexander-Sefre","year":"2006","journal-title":"Gynecol Oncol"},{"issue":"2","key":"zoi250374r9","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.ygyno.2020.05.029","article-title":"Risk factors and long-term impact of urologic complications during radical hysterectomy for cervical cancer in China, 2004-2016.","volume":"158","author":"Liu","year":"2020","journal-title":"Gynecol Oncol"},{"issue":"1","key":"zoi250374r10","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ygyno.2020.04.686","article-title":"Comparison of urologic complications between laparoscopic radical hysterectomy and abdominal radical hysterectomy: a nationwide study from the National Health Insurance.","volume":"158","author":"Hwang","year":"2020","journal-title":"Gynecol Oncol"},{"issue":"7","key":"zoi250374r11","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1111\/aogs.13812","article-title":"Short-term surgical complications after radical hysterectomy\u2014a nationwide cohort study.","volume":"99","author":"Wenzel","year":"2020","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"6","key":"zoi250374r12","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1002\/cncr.22899","article-title":"Utility of parametrectomy for early stage cervical cancer treated with radical hysterectomy.","volume":"110","author":"Wright","year":"2007","journal-title":"Cancer"},{"issue":"1","key":"zoi250374r13","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/AOG.0b013e3181ab474d","article-title":"Parametrial involvement in radical hysterectomy specimens for women with early-stage cervical cancer.","volume":"114","author":"Frumovitz","year":"2009","journal-title":"Obstet Gynecol"},{"issue":"3","key":"zoi250374r14","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ygyno.2010.12.352","article-title":"Conservative management of early stage cervical cancer: is there a role for less radical surgery?","volume":"120","author":"Schmeler","year":"2011","journal-title":"Gynecol Oncol"},{"issue":"10","key":"zoi250374r15","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1136\/ijgc-2021-002921","article-title":"ConCerv: a prospective trial of conservative surgery for low-risk early-stage cervical cancer.","volume":"31","author":"Schmeler","year":"2021","journal-title":"Int J Gynecol Cancer"},{"issue":"9","key":"zoi250374r16","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1056\/NEJMoa2308900","article-title":"Simple versus radical hysterectomy in women with low-risk cervical cancer.","volume":"390","author":"Plante","year":"2024","journal-title":"N Engl J Med"},{"issue":"12","key":"zoi250374r18","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1001\/jamaoncol.2016.6905","article-title":"Using the National Cancer Database for outcomes research: a review.","volume":"3","author":"Boffa","year":"2017","journal-title":"JAMA Oncol"},{"issue":"6","key":"zoi250374r19","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1245\/s10434-019-07213-1","article-title":"Incident cases captured in the National Cancer Database compared with those in U.S. population based central cancer registries in 2012-2014.","volume":"26","author":"Mallin","year":"2019","journal-title":"Ann Surg Oncol"},{"issue":"16","key":"zoi250374r20","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1002\/sim.5705","article-title":"The performance of different propensity score methods for estimating marginal hazard ratios.","volume":"32","author":"Austin","year":"2013","journal-title":"Stat Med"},{"issue":"1","key":"zoi250374r21","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12874-022-01559-z","article-title":"Analyzing differences between restricted mean survival time curves using pseudo-values.","volume":"22","author":"Ambrogi","year":"2022","journal-title":"BMC Med Res Methodol"},{"issue":"1","key":"zoi250374r22","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/biom.13414","article-title":"Restricted mean survival time as a function of restriction time.","volume":"78","author":"Zhong","year":"2022","journal-title":"Biometrics"},{"issue":"6","key":"zoi250374r23","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1097\/AOG.0000000000003523","article-title":"Trends in use and effect on survival of simple hysterectomy for early-stage cervical cancer.","volume":"134","author":"Sia","year":"2019","journal-title":"Obstet Gynecol"},{"issue":"29","key":"zoi250374r24","doi-asserted-by":"publisher","first-page":"4605","DOI":"10.1200\/JCO.22.02769","article-title":"Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix.","volume":"41","author":"Peters","year":"2023","journal-title":"J Clin Oncol"},{"issue":"2","key":"zoi250374r25","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1006\/gyno.1999.5387","article-title":"A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: a Gynecologic Oncology Group study.","volume":"73","author":"Sedlis","year":"1999","journal-title":"Gynecol Oncol"},{"issue":"1","key":"zoi250374r26","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ygyno.2018.04.571","article-title":"Less versus more radical surgery in stage IB1 cervical cancer: a population-based study of long-term survival.","volume":"150","author":"Tseng","year":"2018","journal-title":"Gynecol Oncol"},{"issue":"20","key":"zoi250374r27","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1056\/NEJMoa1806395","article-title":"Minimally invasive versus abdominal radical hysterectomy for cervical cancer.","volume":"379","author":"Ramirez","year":"2018","journal-title":"N Engl J Med"},{"issue":"20","key":"zoi250374r28","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1056\/NEJMoa1804923","article-title":"Survival after minimally invasive radical hysterectomy for early-stage cervical cancer.","volume":"379","author":"Melamed","year":"2018","journal-title":"N Engl J Med"},{"issue":"4","key":"zoi250374r29","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1136\/ijgc-2022-004092","article-title":"Proof-of-concept randomized phase II non-inferiority trial of simple versus type B2 hysterectomy in early-stage cervical cancer =2 cm (LESSER).","volume":"33","author":"Carneiro","year":"2023","journal-title":"Int J Gynecol Cancer"},{"issue":"2","key":"zoi250374r30","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2021.32.e17","article-title":"Comparison between laparoscopic and abdominal radical hysterectomy for stage IB1 and tumor size <2 cm cervical cancer with visible or invisible tumors: a multicentre retrospective study.","volume":"32","author":"Li","year":"2021","journal-title":"J Gynecol Oncol"},{"issue":"1","key":"zoi250374r31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ygyno.2019.01.008","article-title":"Comparison of survival outcomes between minimally invasive surgery and conventional open surgery for radical hysterectomy as primary treatment in patients with stage IB1-IIA2 cervical cancer.","volume":"153","author":"Kim","year":"2019","journal-title":"Gynecol Oncol"},{"issue":"10","key":"zoi250374r32","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1200\/JCO.19.03012","article-title":"Recurrence rates in patients with cervical cancer treated with abdominal versus minimally invasive radical hysterectomy: a multi-institutional retrospective review study.","volume":"38","author":"Uppal","year":"2020","journal-title":"J Clin Oncol"},{"issue":"3","key":"zoi250374r33","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.ygyno.2019.06.023","article-title":"Comparison of laparoscopic and abdominal radical hysterectomy in early stage cervical cancer patients without adjuvant treatment: ancillary analysis of a Korean Gynecologic Oncology Group study (KGOG 1028).","volume":"154","author":"Paik","year":"2019","journal-title":"Gynecol Oncol"},{"issue":"7","key":"zoi250374r34","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1136\/ijgc-2021-002505","article-title":"Oncologic outcomes of minimally invasive versus open radical hysterectomy for early stage cervical carcinoma and tumor size <2 cm: a systematic review and meta-analysis.","volume":"31","author":"Nasioudis","year":"2021","journal-title":"Int J Gynecol Cancer"},{"issue":"9","key":"zoi250374r35","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1136\/ijgc-2020-001506","article-title":"SUCCOR study: an international European cohort observational study comparing minimally invasive surgery versus open abdominal radical hysterectomy in patients with stage IB1 cervical cancer.","volume":"30","author":"Chiva","year":"2020","journal-title":"Int J Gynecol Cancer"},{"issue":"5","key":"zoi250374r36","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1136\/ijgc-2019-000994","article-title":"Comparison of laparoscopic and open radical hysterectomy in cervical cancer patients with tumor size =2 cm.","volume":"30","author":"Chen","year":"2020","journal-title":"Int J Gynecol Cancer"},{"key":"zoi250374r37","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1186\/s12885-015-1818-4","article-title":"Laparoscopy versus laparotomy for the management of early stage cervical cancer.","volume":"15","author":"Wang","year":"2015","journal-title":"BMC Cancer"},{"issue":"6","key":"zoi250374r38","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1136\/ijgc-2019-000558","article-title":"Robot-assisted approach to cervical cancer (RACC): an international multi-center, open-label randomized controlled trial.","volume":"29","author":"Falconer","year":"2019","journal-title":"Int J Gynecol Cancer"},{"issue":"16","key":"zoi250374r39","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.TPS5605","article-title":"ROCC\/GOG-3043: a randomized non-inferiority trial of robotic versus open radical hysterectomy for early-stage cervical cancer.","volume":"40","author":"Bixel","year":"2022","journal-title":"J Clin Oncol"},{"key":"zoi250374r40","doi-asserted-by":"publisher","first-page":"S58","DOI":"10.1016\/j.ygyno.2024.07.088","article-title":"Evaluation of physical function and quality of life before and after non-radical surgical therapy (extra fascial hysterectomy or cone biopsy with pelvic lymphadenectomy) for stage IA1 (LVSI+) and IA2-IB1 cervical cancer (GOG-278).","volume":"190","author":"Covens","year":"2024","journal-title":"Gynecol Oncol"},{"issue":"2","key":"zoi250374r41","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1200\/JCO.24.00440","article-title":"Sexual health and quality of life in patients with low-risk early-stage cervical cancer: results from GCIG\/CCTG CX.5\/SHAPE trial comparing simple versus radical hysterectomy.","volume":"43","author":"Ferguson","year":"2024","journal-title":"J Clin Oncol"},{"issue":"6","key":"zoi250374r42","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1097\/AOG.0000000000003589","article-title":"Simple hysterectomy for early-stage cervical cancer: caution, but don\u2019t throw the baby out with the bathwater!","volume":"134","author":"Nguyen","year":"2019","journal-title":"Obstet Gynecol"},{"issue":"4","key":"zoi250374r43","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.ajog.2020.11.041","article-title":"Less radical surgery for early-stage cervical cancer: a systematic review.","volume":"224","author":"Wu","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"zoi250374r3","unstructured":"National Cancer Institute. Cancer stat facts: cervical cancer. Accessed April 8, 2025. https:\/\/seer.cancer.gov\/statfacts\/html\/cervix.html"},{"key":"zoi250374r4","unstructured":"National Comprehensive Cancer Network. NCCN guidelines: cervical cancer version 1. 2023. Accessed April 8, 2025. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/cervical.pdf"},{"key":"zoi250374r17","unstructured":"National Comprehensive Cancer Network. NCCN guidelines: cervical cancer. Published 2024. Accessed April 8, 2025. https:\/\/www.nccn.org\/patients\/guidelines\/content\/PDF\/cervical-patient-guideline.pdf"}],"container-title":["JAMA Network Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/articlepdf\/2834115\/tarney_2025_oi_250374_1746730718.80304.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T15:00:43Z","timestamp":1747321243000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2834115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1001\/jamanetworkopen.2025.10717","relation":{},"ISSN":["2574-3805"],"issn-type":[{"value":"2574-3805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]}}}