{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T07:57:03Z","timestamp":1794124623235,"version":"4.8.0"},"reference-count":41,"publisher":"American Medical Association (AMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Respiratory viral infections (RVIs) are associated with elevated cardiovascular risk; however, less is known about cardiac complications after hospitalization for respiratory syncytial virus (RSV) vs other vaccine-preventable RVIs (COVID-19 or influenza).<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To compare the risk of acute cardiovascular complications in adults hospitalized for RSV vs COVID-19 or influenza.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This population-based cross-sectional study, conducted before RSV vaccination rollout in Singapore, assessed all adults hospitalized for RSV or influenza (January 1, 2017, to June 30, 2024) and all adults hospitalized for COVID-19 during Omicron XBB\/JN.1 transmission (January 1, 2023, to June 30, 2024).<\/jats:p>\n <\/jats:sec>\n \n Exposure<\/jats:title>\n Hospitalization for RSV, influenza (vaccinated or unvaccinated), or COVID-19 (boosted [\u22653 vaccine doses] or unboosted [&amp;lt;3 vaccine doses]).<\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n Cardiovascular events during RSV, influenza, or COVID-19 hospitalization, defined as any cardiac, cerebrovascular, or thrombotic event, occurring from admission until discharge or death. Odds of any cardiovascular event (RSV vs COVID-19 or RSV vs influenza) and severe RVI (intensive care unit admission) with or without an acute cardiovascular event were estimated using multivariate logistic regression, adjusted for sociodemographic and clinical characteristics.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 32\u202f960 RVI hospitalizations (mean [SD] patient age, 66.58 [18.99] years; 17\u202f056 [51.7%] female) were included (2148 for RSV, 14 389 for influenza, and 16 423 for COVID-19). Of the 2148 patients hospitalized for RSV, 234 (10.9%) had an acute cardiovascular event. Higher odds of any acute cardiovascular event (adjusted odds ratio [AOR], 1.31; 95% CI, 1.12-1.54) as well as other individual cardiac events were observed in RSV hospitalizations vs boosted COVID-19 (dysrhythmia: AOR, 1.52; 95% CI, 1.19-1.94; heart failure: AOR, 1.75; 95% CI, 1.30-2.35). Similarly, higher odds of any acute cardiovascular event (AOR, 1.58; 95% CI, 1.24-2.01) as well as dysrhythmias or heart failure were observed in patients hospitalized for RSV vs unboosted COVID-19. Odds of a cardiovascular event were not significantly different in RSV vs influenza, except among contemporaneous hospitalizations after the pandemic (2023-2024), where odds of heart failure (AOR, 2.09; 95% CI, 1.21-3.59) were significantly higher in RSV hospitalizations vs vaccine-breakthrough influenza hospitalizations. Occurrence of a cardiovascular event was associated with greater odds of severe RSV requiring intensive care unit admission (AOR, 2.36; 95% CI, 1.21-4.62).<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this cross-sectional study, 1 in 10 patients hospitalized for RSV had a concurrent acute cardiovascular event. Odds of cardiac events were significantly higher in RSV vs COVID-19 hospitalizations in both vaccine-boosted and unboosted individuals. In contemporaneous hospitalizations for RSV or influenza after the pandemic (2023-2024), odds of heart failure were significantly higher in RSV hospitalizations vs vaccine-breakthrough influenza hospitalizations. These findings suggest that patients with preexisting cardiovascular risk should consider vaccination against RVIs.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.11764","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T11:31:20Z","timestamp":1747913480000},"page":"e2511764","source":"Crossref","is-referenced-by-count":28,"title":["Cardiac Events in Adults Hospitalized for Respiratory Syncytial Virus vs COVID-19 or Influenza"],"prefix":"10.1001","volume":"8","author":[{"given":"Liang En","family":"Wee","sequence":"first","affiliation":[{"name":"National Centre for Infectious Diseases, Singapore"},{"name":"Duke-NUS Graduate Medical School, National University of Singapore, Singapore"},{"name":"Department of Infectious Diseases, Singapore General Hospital, Singapore"},{"name":"Department of Infection Prevention and Epidemiology, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue 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