{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:09:16Z","timestamp":1794348556934,"version":"4.9.0"},"reference-count":63,"publisher":"American Medical Association (AMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"\n Importance<\/jats:title>\n Living alone and mental health disorders, including depression and anxiety, are associated with high suicide risk, but their combined impact remains underexplored.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To examine the association of living arrangements and depression or anxiety with suicide risk.<\/jats:p>\n <\/jats:sec>\n \n Design, Setting, and Participants<\/jats:title>\n This population-based cohort study used data from the Korean National Health Insurance Service database from January 1, 2009, to December 31, 2021, that included adults aged 20 years or older who participated in the General Health Screening Program in Korea in 2009. Individuals with incomplete data and those who died by suicide within the first year were excluded to minimize the possibility of reverse causation. Data were analyzed from December 28, 2023, to December 27, 2024.<\/jats:p>\n <\/jats:sec>\n \n Exposures<\/jats:title>\n \n Living arrangements, categorized as living alone (\u22655 years) or living with others, and depression and anxiety, determined using\n International Statistical Classification of Diseases and Related Health Problems, Tenth Revision<\/jats:italic>\n codes.\n <\/jats:p>\n <\/jats:sec>\n \n Main Outcomes and Measures<\/jats:title>\n The primary outcome was death by suicide, identified through national death records. Multivariable Cox proportional hazards regression models were used to estimate adjusted hazard ratios (AHRs) and 95% CIs for suicide risk.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The study included 3\u202f764\u202f279 adults (mean [SD] age, 47.2 [14.0] years; 55.8% male). Of these individuals, 112\u202f460 (3.0%) had depression, 232\u202f305 (6.2%) had anxiety, and 319\u202f993 (8.5%) lived alone. Compared with individuals who had neither depression nor anxiety nor lived alone, individuals living alone with both depression and anxiety exhibited a 558% increased risk of suicide (AHR, 6.58 [95% CI, 4.86-8.92]). Living alone with depression was associated with a 290% increased risk (AHR, 3.91 [95% CI, 2.96-5.16]), and living alone with anxiety was associated with a 90% increased risk (AHR, 1.90 [95% CI, 1.48-2.43]). The AHRs were higher for the association between living alone and suicide among middle-aged individuals (aged 40 to 64 years) and men compared with other demographic groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Relevance<\/jats:title>\n In this cohort study of 3\u202f764\u202f279 individuals, living alone with depression or anxiety was associated with an increased risk of suicide, particularly among middle-aged individuals and men. These findings underscore the importance of preventing mental illness, such as depression and anxiety, while addressing living arrangements as a critical factor in suicide risk assessments for individuals with these conditions.<\/jats:p>\n <\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.1227","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T12:18:25Z","timestamp":1742991505000},"page":"e251227","source":"Crossref","is-referenced-by-count":22,"title":["Suicide Risk and Living Alone With Depression or Anxiety"],"prefix":"10.1001","volume":"8","author":[{"given":"Daa Un","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Campus Charit\u00e9 Mitte, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Psychiatric University Hospital Charit\u00e9 at St. Hedwig Hospital, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyewon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hallym University Sacred Heart Hospital, Anyang, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science, Soongsil University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Depression Center, Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"},{"name":"Department of Health Sciences & Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, South Korea"},{"name":"Department of Medical Device Management & Research, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, South Korea"},{"name":"Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"issue":"3","key":"zoi250088r3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000785","article-title":"Worldwide impact of economic cycles on suicide trends over 3 decades: differences according to level of development. 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