{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:19:31Z","timestamp":1788909571352,"version":"build-2803163510"},"reference-count":24,"publisher":"American Medical Association (AMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Non\u2013English language preference (NELP) poses a challenge in health care delivery and may contribute to disparate outcomes. Understanding the impact of NELP can provide insight for health care professionals, policymakers, and advocates aiming to enhance care quality for diverse populations.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate the association of NELP with breast cancer\u2013related outcomes.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This single-center cohort study of patients with breast cancer treated with curative intent was performed at a tertiary academic medical center from January 1, 2000, to December 31, 2020. A total of 22\u202f355 patients were included in the initial cohort acquired through electronic medical record data; 2261 had complete data when cross-referenced with the institutional cancer registry. Data were analyzed from January 8 to December 11, 2024.<\/jats:p><\/jats:sec>Exposure<\/jats:title>Language preference.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary end point was disease-specific survival (DSS) rates for patients with NELP compared with patients with English language preference (ELP), with adjustment for baseline clinical and demographic characteristics and treatments. Secondary end points included disease-free survival (DFS) and overall survival (OS). Time from diagnosis to definitive surgery was also analyzed. Kaplan-Meier analyses and log-rank tests were used to compare survival in the NELP and ELP groups.<\/jats:p><\/jats:sec>Results<\/jats:title>The 2261 patients included in the analysis consisted of 2023 with ELP and 238 with NELP (2240 female [99.1%]; mean [SD] age, 59.6 [12.3] years). Clinical and treatment data were well balanced between the NELP and ELP groups. Median follow-up was 60.0 (IQR, 40.0-76.6) months. Median time between biopsy and definitive surgery was significantly longer for the NELP group compared with the ELP group (49 [IQR, 29-75] vs 38 [IQR, 24-57] days; P<\/jats:italic>\u2009&amp;lt;\u2009.001). Stratified by insurance, only those with Medicare had significant delays between biopsy and surgery (median, 54 [IQR, 29-96] vs 36 [IQR, 25-53] days; P<\/jats:italic>\u2009&amp;lt;\u2009.001). Five-year DSS rates for the NELP and ELP groups were 98.5% (95% CI, 93.8%-99.6%) and 99.0% (95% CI, 98.3%-99.4%), respectively (log-rank P<\/jats:italic>\u2009=\u2009.39). DFS was 93.9% (95% CI, 89.4%-96.5%) for the NELP group and 95.6% (95% CI, 94.4%-96.5%) for the ELP group (log-rank P<\/jats:italic>\u2009=\u2009.96). OS was 94.4% (95% CI, 89.3%-97.1%) for the NELP group and 96.7% (95% CI, 95.7%-97.5%) for the ELP group (log-rank P<\/jats:italic>\u2009=\u2009.26).<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this cohort study examining the association of NELP with breast cancer outcomes, patients with NELP had significant delays in definitive surgical management compared with patients with ELP, but DSS, DFS, and OS did not differ significantly between groups. This suggests the importance of having robust support systems to mitigate language-related disparities and preserve breast cancer outcomes in this vulnerable population.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.14036","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T15:30:50Z","timestamp":1749137450000},"page":"e2514036","source":"Crossref","is-referenced-by-count":5,"title":["Non\u2013English Language Preference and Breast Cancer Outcomes"],"prefix":"10.1001","volume":"8","author":[{"given":"Daphna Y.","family":"Spiegel","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Levey","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, 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