{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:10:16Z","timestamp":1792253416774,"version":"4.4.0"},"reference-count":29,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Trisomy 13 (T13) and trisomy 18 (T18) are chromosomal abnormalities with high mortality rates in the first year of life. Understanding differences in long-term survival between children with full vs mosaic or partial trisomy is crucial for prognosis and health care planning.<\/jats:p><\/jats:sec>Objective<\/jats:title>To examine the differences in 10-year survival between children with full T13 and T18 vs those with mosaic or partial trisomy.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This retrospective, population-based cohort study assessed liveborn infants with T13 and T18 in the Texas Birth Defects Registry (deliveries from January 1, 1999, to December 31, 2008). Follow-up was through December 31, 2018 (the last date available at the time of analyses) to allow for 10 years of follow-up for all infants. All analyses were conducted from January 1, 2022, to December 31, 2024.<\/jats:p><\/jats:sec>Exposures<\/jats:title>Cytogenetic status (full trisomy vs mosaic or partial trisomy).<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>The primary outcome was survival to 10 years of age, assessed using Kaplan-Meier survival estimates. The association between cytogenetic status and mortality by 10 years of age was assessed using Cox proportional hazards regression to generate hazard ratios (HRs). Population attributable fraction was calculated to determine the percentage of survival attributable to mosaic or partial trisomy status.<\/jats:p><\/jats:sec>Results<\/jats:title>The study cohort included 798 infants (463 female infants [58.0%]; mean [SD] maternal age, 30.9 [8.0] years) with T13 (n\u2009=\u2009295) or T18 (n\u2009=\u2009503). Among all cases with T13, 25 infants (8.5%; 95% CI, 5.5%-12.3%) survived to 10 years of age. Similarly, among all infants with T18, 43 (8.6%; 95% CI, 6.3%-11.3%) survived to 10 years of age. Kaplan-Meier survival estimates to 10 years of age were statistically significantly higher among children with mosaic or partial trisomy (13 [25.0%] and 14 [43.8%], respectively) compared with full trisomy (12 [4.9%] and 29 [6.6%], respectively) (both P<\/jats:italic>\u2009&amp;lt;\u2009.001). Infants with full trisomy had statistically significantly increased 10-year mortality hazards compared with those with mosaic or partial trisomy for both T13 (HR, 2.00; 95% CI, 1.42-2.82) and T18 (HR, 3.34; 95% CI, 2.08-5.38). The results of the calculated proportion of 10-year survival due to the presence of nonfull trisomy status (population attributable fraction) was 41.7% for children with T13 and 27.9% for children with T18.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>The findings of this cohort study of infants with T13 and T18 support differences in long-term survival based on cytogenetic status and emphasize the need to potentially reassess the context of these conditions generally being considered incompatible with life, particularly for those with mosaic trisomies. These findings offer context surrounding treatment decisions, such as withholding interventions, for affected infants in the future.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.29885","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T15:00:35Z","timestamp":1757343635000},"page":"e2529885","source":"Crossref","is-referenced-by-count":7,"title":["Long-Term Survival Among Children With Trisomy 13 and Trisomy 18 by Cytogenetic Status"],"prefix":"10.1001","volume":"8","author":[{"given":"Katherine L.","family":"Ludorf","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata H.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Shumate","sequence":"additional","affiliation":[{"name":"Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Canfield","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Austin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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