{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:27:08Z","timestamp":1788380828997,"version":"build-2803163510"},"reference-count":47,"publisher":"American Medical Association (AMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAMA Netw Open"],"abstract":"Importance<\/jats:title>Subjective cognitive decline (SCD) may be an early indicator of Alzheimer disease and related dementias (ADRD), yet its association with plasma biomarkers remains unclear among middle-aged and older adults (aged 50-86 years).<\/jats:p><\/jats:sec>Objective<\/jats:title>To examine associations between plasma biomarkers of amyloid, tau, neuroaxonal damage, and glial activation with SCD in a heterogeneous cohort of Hispanic and\/or Latino adults.<\/jats:p><\/jats:sec>Design, Setting, and Participants<\/jats:title>This cross-sectional study used survey-weighted data from the Study of Latinos\u2013Investigation of Neurocognitive Aging, an ancillary study of the Hispanic Community Health Study\/Study of Latinos. Participants were aged 50 to 86 years and resided in 4 major US cities. Data were collected from 2016 to 2018 and analyzed between December 2024 and June 2025.<\/jats:p><\/jats:sec>Exposure<\/jats:title>Plasma biomarkers included amyloid-beta (A\u03b242\/40<\/jats:sub>), phosphorylated tau-181 (ptau-181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP), quantified using Simoa (Quanterix HD-X) and log-transformed (ln) to reduce skewness.<\/jats:p><\/jats:sec>Main Outcomes and Measures<\/jats:title>SCD was assessed using the short-form Everyday Cognition Scale (ECog-12), evaluating global-, executive-, and memory-related SCD, and a single-item cognitive concerns question. Survey-weighted linear and logistic regression models tested associations between biomarkers and SCD, adjusting for demographic, cardiovascular, kidney, and APOE<\/jats:italic> genotype covariates.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 5712 adults (mean [SD] age, 63.47 (8.15) years; unweighted 3663 [53.92%] female), higher ln(ptau-181) was associated with ECog-12 memory (unstandardized \u03b2\u2009=\u20090.088; 95% CI, 0.005-0.170). Higher ln(NfL) levels were associated with greater ECog-12 global (unstandardized \u03b2\u2009=\u20090.169; 95% CI, 0.074-0.265), executive (unstandardized \u03b2\u2009=\u20090.182; 95% CI, 0.087-0.277), and memory (unstandardized \u03b2\u2009=\u20090.156; 95% CI, 0.065-0.248) domains. Higher ln(GFAP) levels were associated with greater ECog-12 global (unstandardized \u03b2\u2009=\u20090.109; 95% CI, 0.019-0.198) and executive (unstandardized \u03b2\u2009=\u20090.121; 95% CI, 0.031-0.211) domains. Ln(A\u03b242\/40<\/jats:sub>) was not associated with SCD domains. Cognitive concerns significantly modified the associations between ln(NfL) and ECog-12 domains, with more pronounced associations among those reporting cognitive concerns. No biomarkers were associated with the single-item cognitive concerns score.<\/jats:p><\/jats:sec>Conclusions and Relevance<\/jats:title>In this study of middle-aged and older Hispanic and\/or Latino adults, plasma biomarkers of p-tau181, NfL, and GFAP, but not A\u03b242\/40<\/jats:sub>, were associated with greater SCD. These findings underscore their potential utility in early ADRD detection strategies.<\/jats:p><\/jats:sec>","DOI":"10.1001\/jamanetworkopen.2025.31038","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T15:31:15Z","timestamp":1757086275000},"page":"e2531038","source":"Crossref","is-referenced-by-count":8,"title":["Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and\/or Latino Adults"],"prefix":"10.1001","volume":"8","author":[{"given":"Freddie","family":"M\u00e1rquez","sequence":"first","affiliation":[{"name":"Department of Neurosciences, University of California, San Diego, La Jolla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Tarraf","sequence":"additional","affiliation":[{"name":"Institute of Gerontology and Department of Healthcare Sciences, Wayne State University, Detroit, 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